Agen alkilasi

Apa iku agen alkilasi?

Agen alkilasi yaiku senyawa sing kerjane kanthi nambahake gugus alkil menyang basa guanin saka molekul DNA, nyegah untaian heliks ganda ora nyambung kaya sing kudune. Iki nyebabake rusak untaian DNA, mengaruhi kemampuan sel kanker kanggo multiply. Pungkasane, sel kanker mati. Agen alkylating minangka salah sawijining obat kelas pertama sing digunakake kanggo kanker. Ana limang kategori tradisional agen alkilasi:

  • Sawi nitrogen (contone, bendamustine, chlorambucil, cyclophosphamide, ifosfamide, mechlorethamine, melphalan)
  • Nitrosoureas (contone, carmustine, lomustine , streptozocin)
  • Alkil sulfonat (contone, busulfan)
  • Triazin (contone, dacarbazine, temozolomide)
  • Ethylenimines (contone, altretamine, thiotepa)

Trabectedin digolongake minangka alkaloid tetrahydroisoquinoline, lan ora kaya agen alkilasi tradisional, trabectedin ngiket menyang alur minor DNA lan alkylates guanin ing posisi N2. Agen alkilasi efektif sajrone saben fase siklus urip sel kanker, sing tegese efektif kanggo nambani macem-macem kanker. Paling efektif kanggo nambani kanker sing tuwuh alon kayata leukemia lan tumor padhet, nanging uga digunakake kanggo perawatan kanker payudara, paru-paru, ovarium, lan prostat; limfoma, myeloma, lan sarcoma; lan penyakit Hodgkin. Amarga agen alkilasi mengaruhi kabeh sel sing kerep dibagi, uga beracun kanggo sel normal, utamane ing saluran pencernaan, sumsum balung, testis, lan ovarium. Cathetan: Sanajan agen antikanker sing ngemot platinum, carboplatin, cisplatin, lan oxaliplatin asring diklasifikasikake minangka agen alkilasi, nanging ora. Iki nyebabake tambahan DNA kovalen kanthi cara liya.

Dhaptar obat karo Agen alkilasi

Jeneng Obat
Alkeran
Generic name: Melphalan
Alkeran IV
Generic name: Melphalan
Cyclophosphamide
Generic name: Cyclophosphamide
Cyclophosphamide oral and injection
Generic name: Cyclophosphamide (oral/injection)
Cytoxan
Generic name: Cyclophosphamide
Cytoxan Lyophilized
Generic name: Cyclophosphamide
Mustargen
Generic name: Mechlorethamine
Belrapzo
Generic name: Bendamustine
Bendamustine
Generic name: Bendamustine
Bendeka
Generic name: Bendamustine
Bicnu
Generic name: Carmustine
BiCNU injection/implant
Generic name: Carmustine (injection/implant)
Busulfan
Generic name: Busulfan
Busulfan oral/injection
Generic name: Busulfan (oral/injection)
Busulfex
Generic name: Busulfan
Carboplatin
Generic name: Carboplatin
Carmustine (Implantation)
Generic name: Carmustine
Carmustine (Intravenous)
Generic name: Carmustine
Carmustine injection/implant
Generic name: Carmustine (injection/implant)
Ceenu
Generic name: Lomustine
Chlorambucil
Generic name: Chlorambucil
Cisplatin
Generic name: Cisplatin
Dacarbazine
Generic name: Dacarbazine
Dtic-Dome
Generic name: Dacarbazine
Eloxatin
Generic name: Oxaliplatin
Evomela
Generic name: Melphalan
Gleostine
Generic name: Lomustine
Gliadel
Generic name: Carmustine
Gliadel injection/implant
Generic name: Carmustine (injection/implant)
Hepzato
Generic name: Melphalan
Ifex
Generic name: Ifosfamide
Ifosfamide
Generic name: Ifosfamide
Leukeran
Generic name: Chlorambucil
Lomustine
Generic name: Lomustine
Lurbinectedin
Generic name: Lurbinectedin
Mechlorethamine (Intravenous)
Generic name: Mechlorethamine
Melphalan (Intra-arterial, Intravenous)
Generic name: Melphalan
Melphalan (Oral)
Generic name: Melphalan
Melphalan flufenamide
Generic name: Melphalan Flufenamide
Melphalan oral/injection
Generic name: Melphalan (oral/injection)
Oxaliplatin
Generic name: Oxaliplatin
Paraplatin
Generic name: Carboplatin
Paraplatin NovaPlus
Generic name: Carboplatin
Pepaxto
Generic name:  melphalan Flufenamide
Platinol
Generic name: Cisplatin
Platinol-AQ
Generic name: Cisplatin
Streptozocin
Generic name: Streptozocin
Temodar
Generic name: Temozolomide
Temodar (Temozolomide Intravenous)
Generic name: Temozolomide
Temodar (Temozolomide Oral)
Generic name: Temozolomide
Temozolomide (Intravenous)
Generic name: Temozolomide
Temozolomide (Oral)
Generic name: Temozolomide
Temozolomide oral/injection
Generic name: Temozolomide (oral/injection)
Tepadina
Generic name: Thiotepa
Thioplex
Generic name: Thiotepa
Thiotepa
Generic name: Thiotepa
Trabectedin
Generic name: Trabectedin
Treanda
Generic name: Bendamustine
Vivimusta
Generic name: Bendamustine
Yondelis
Generic name: Trabectedin
Zanosar
Generic name: Streptozocin
Zepzelca
Generic name:  lurbinectedin (for Injection)

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