Obat anti-inflamasi nonsteroid

Apa iku obat anti-inflamasi nonsteroid (NSAIDs)?

Agen anti-inflamasi nonsteroid (biasane disingkat NSAID) yaiku klompok obat sing nyuda rasa nyeri lan mriyang lan nyuda inflamasi.

Ana saklawasé rong lusin NSAID sing beda-beda sing kasedhiya, nanging kabeh padha dianggo kanthi cara sing padha, yaiku kanthi ngalangi klompok enzim tartamtu sing disebut enzim siklo-oksigenase, asring disingkat enzim COX. Enzim iki tanggung jawab kanggo produksi prostaglandin. Prostaglandin minangka klompok senyawa kanthi efek kaya hormon sing ngontrol macem-macem proses kayata inflamasi, aliran getih, lan pembentukan gumpalan getih.

Agen anti-inflamasi nonsteroid digunakake kanggo apa?

Obat NSAID digunakake kanggo nambani rasa nyeri entheng nganti sedheng sing muncul saka macem-macem kondisi kayata ngelu, menstruasi, migren, osteoarthritis utawa rheumatoid arthritis, sprains lan galur, lan lara untu.

Aspirin minangka NSAID sing digunakake ing dosis cilik kanggo nyuda risiko serangan jantung utawa stroke sing disebabake dening gumpalan getih. Bisa uga diwenehake minangka dosis siji nalika serangan jantung kanggo nambah asil. Iki amarga ora bisa dibatalake nyegah enzim COX-1.

Apa bedane antarane agen anti-inflamasi nonsteroid?

NSAID bisa dikelompokake miturut preferensi kanggo COX-1 lan enzim COX-2. Sing milih COX-1 luwih cenderung nyebabake efek samping gastrointestinal. Sing milih COX-2 duwe risiko efek kardiovaskular sing luwih dhuwur nanging efek gastrointestinal kurang. Dosis NSAID sing luwih dhuwur cenderung nyebabake inhibisi enzim COX-2 luwih akeh (lan luwih akeh efek samping kardiovaskular), sanajan ing NSAID sing biasane dianggep kurang resiko (kayata ibuprofen). NSAID kanthi aktivitas sing luwih dhuwur nglawan enzim COX-2 kudu digunakake kanthi ati-ati ing wong sing nandhang penyakit kardiovaskuler utawa kanthi risiko tambah penyakit kardiovaskular.

Loro jinis enzim COX ngasilake prostaglandin; Nanging, fungsi utama enzim COX-1 yaiku ngasilake tingkat prostaglandin awal sing ngaktifake trombosit lan nglindhungi lapisan saluran pencernaan, dene enzim COX-2 tanggung jawab kanggo ngeculake prostaglandin sawise infeksi utawa ciloko.

Umume NSAID nyandhet enzim kasebut ing tingkat tartamtu.

Dhaptar NSAID Umum

< td> flurbiprofen < td> Advil, Motrin, Genpril td>

*Diurutake saka aktivitas COX-2 paling sithik nganti paling dhuwur ing grup kasebut.

Elinga yen peringkat selektivitas beda-beda gumantung saka sumber daya sing digunakake. Tabel iki adhedhasar akumulasi data sing paling apik.

Apa agen anti-inflamasi nonsteroid aman?

NSAID minangka salah sawijining klompok obat sing paling akeh diresepake; Nanging, ana hubungane karo sawetara efek samping sing serius.

NSAID bisa nambah risiko serangan jantung utawa stroke sing fatal. Resiko mundhak dosis sing luwih dhuwur lan suwene wektu sampeyan tetep ing NSAID. Wong sing duwe penyakit jantung sing wis ana luwih beresiko lan NSAID tartamtu, kayata diclofenac lan celecoxib, wis disambungake karo efek samping sing gegandhengan karo jantung tinimbang liyane. NSAID ora kena digunakake sadurunge utawa sawise operasi bypass jantung (coronary artery bypass graft, utawa CABG).

Efek samping gastrointestinal (GI) uga umum, lan biasane ana hubungane karo dosis lan durasi perawatan sanajan sawetara NSAIDs, kayata ketorolac, aspirin lan indomethacin, digandhengake karo risiko sing luwih dhuwur. Wong tuwa utawa sing njupuk obat liya sing ngganggu weteng luwih cenderung ngalami efek samping GI sing ngancam nyawa, kayata getihen weteng utawa usus. 18 taun. Ibuprofen minangka siji-sijine NSAID sing disetujoni kanggo bocah-bocah umur telung sasi utawa luwih. Aspirin bisa nambah risiko sindrom Reye yen diwenehake marang bocah-bocah sing nandhang penyakit virus. Aja menehi aspirin kanggo bocah-bocah kajaba ing saran saka dokter.

Akeh-akehe NSAID ora kudu dijupuk sajrone telung sasi pungkasan meteng utawa nalika nyusoni kajaba miturut saran saka dokter.

Apa sing kudu ditindakake. efek samping saka agen anti-inflamasi nonsteroid?

NSAID duweni potensi bisa nyebabake sawetara efek samping, utamane yen digunakake ing dosis sing luwih dhuwur tinimbang sing disaranake kanggo wektu sing suwe.

Efek samping gastrointestinal sing bisa kedadeyan kalebu kembung, diare, constipation, iritasi lapisan weteng, mual utawa muntah.

NSAID uga bisa mengaruhi fungsi ginjel lan nyuda sepira cepet getih mili liwat ginjel. Bisa nyebabake natrium lan banyu sing bisa nyebabake edema lan tingkat kalium sing dhuwur. Kadhangkala, bisa nyebabake karusakan ginjel sing luwih serius.

Sawetara NSAID, utamane diklofenak lan sing selektif kanggo enzim COX-2, duwe risiko dhuwur kanggo kedadeyan trombotik kardiovaskular kayata serangan jantung utawa stroke. . Efek samping liyane sing ana gandhengane karo jantung kayata tekanan darah tinggi, gagal jantung kongestif, lan palpitasi uga wis dilaporake.

Kajaba iku, sawetara wong sing njupuk NSAID wis ngalami serangan asma, getihen, lemes, sirah, insomnia, tingkat neutrofil kurang, urtikaria (hives), vertigo lan kejang. Sindrom Reye, kondisi sing ngancam nyawa sing nyebabake pembengkakan ing ati lan otak lan umume digandhengake karo panggunaan aspirin ing bocah cilik uga wis dilaporake.

Dhaptar obat karo Obat anti-inflamasi nonsteroid

Jeneng umum	Jeneng merek
Pilihan liyane COX-1*
Ansaid
ketorolac	Mung generik
ketoprofen	Oruvail
tolmetin	Generik
aspirin	Ecotrin, Miniprin, lan generik
Relatif nonselektif
ibuprofen
naproxen	Aleve, Flanax Pain Reliever, Naprosyn
Kurang saka 50 kali lipat COX-2 selektif*
indometasin	Indocin, Tivorbex
sulindac	Klinoril
piroxicam	Feldene
asam mefenamat	Ponstel
meloxicam	Mobic
diklofenak	Cataflam, Voltaren, Zipsor, Zorvolex
celecoxib	Celebrex
etodolac	Umum
Luwih saka 50 kali lipat COX-2 selektif
etoricoxib	Ora disetujoni ing AS
lumiracoxib	Ora disetujoni ing AS
rofecoxib	Dibuwang amarga masalah keamanan

Jeneng Obat
Addaprin Generic name: Ibuprofen
Advil Generic name: Ibuprofen
Advil Migraine Generic name: Ibuprofen
Aflaxen Generic name: Naproxen
A-G Profen Generic name: Ibuprofen
Aleve Generic name: Naproxen
Aleve Arthritis Generic name: Naproxen
Aleve Back and Muscle Pain Generic name: Naproxen
Aleve Easy Open Arthritis Generic name: Naproxen
Aleve Liquid Gels Generic name: Naproxen
Anaprox Generic name: Naproxen
Anaprox-DS Generic name: Naproxen
Anjeso Generic name: Meloxicam
Ansaid Generic name: Flurbiprofen
Arthrotec Generic name: Diclofenac And Misoprostol
Clinoril Generic name: Sulindac
Bufen Generic name: Ibuprofen
Caldolor Generic name: Ibuprofen Injection
Cambia Generic name: Diclofenac
Cataflam Generic name: Diclofenac
Children's Advil Generic name: Ibuprofen
Children's Ibuprofen Berry Generic name: Ibuprofen
Children's Motrin Generic name: Ibuprofen
Daypro Generic name: Oxaprozin
Diclofenac Generic name: Diclofenac
Diclofenac (Intravenous) Generic name: Diclofenac
Diclofenac (Oral) Generic name: Diclofenac
Diclofenac and misoprostol Generic name: Diclofenac And Misoprostol
Duexis Generic name: Famotidine And Ibuprofen
Dyloject Generic name: Diclofenac
EC-Naprosyn Generic name: Naproxen
Esomeprazole and naproxen Generic name: Esomeprazole And Naproxen
Etodolac Generic name: Etodolac
Famotidine and ibuprofen Generic name: Famotidine And Ibuprofen
Feldene Generic name: Piroxicam
Fenoprofen Generic name: Fenoprofen
Flanax Generic name: Naproxen Sodium
Flurbiprofen Generic name: Flurbiprofen
Flurbiprofen (Oral) Generic name: Flurbiprofen
Genpril Generic name: Ibuprofen
Haltran Generic name: Ibuprofen
Ibu Generic name: Ibuprofen
Ibu-2 Generic name: Ibuprofen
Ibu-200 Generic name: Ibuprofen
Ibu-4 Generic name: Ibuprofen
Ibu-6 Generic name: Ibuprofen
Ibu-8 Generic name: Ibuprofen
Ibu-Tab Generic name: Ibuprofen
Ibuprofen Generic name: Ibuprofen
Ibuprofen (Intravenous) Generic name: Ibuprofen
Ibuprofen (Oral) Generic name: Ibuprofen
Ibuprofen and famotidine Generic name: Ibuprofen And Famotidine
Ibuprofen injection Generic name: Ibuprofen Injection
Ibuprofen lysine Generic name: Ibuprofen Lysine
Ibuprohm Generic name: Ibuprofen
Indocin Generic name: Indomethacin
Indocin (Indomethacin Intravenous) Generic name: Indomethacin
Indocin (Indomethacin Oral) Generic name: Indomethacin
Indocin (Indomethacin Rectal) Generic name: Indomethacin
Indocin SR Generic name: Indomethacin
Indomethacin Generic name: Indomethacin
Indomethacin (Intravenous) Generic name: Indomethacin
Indomethacin (Oral) Generic name: Indomethacin
Indomethacin (Rectal) Generic name: Indomethacin
I-Prin Generic name: Ibuprofen
Ketoprofen Generic name: Ketoprofen
Ketorolac nasal Generic name: Ketorolac (nasal)
Ketorolac oral/injection Generic name: Ketorolac (oral/injection)
Lodine Generic name: Etodolac
Lodine XL Generic name: Etodolac
Lofena Generic name: Diclofenac
Meclofenamate Generic name: Meclofenamate
Mefenamic acid Generic name: Mefenamic Acid
Meloxicam Generic name: Meloxicam (oral/injection)
Meloxicam (Intravenous) Generic name: Meloxicam
Meloxicam (Oral) Generic name: Meloxicam
Midol Generic name: Ibuprofen
Midol Extended Relief Generic name: Naproxen
Midol IB Generic name: Ibuprofen
Mobic Generic name: Meloxicam
Motrin Childrens Generic name: Ibuprofen
Motrin IB Generic name: Ibuprofen 200mg
Motrin IB Migraine Generic name: Ibuprofen
Motrin Infant Drops Generic name: Ibuprofen
Motrin Migraine Pain Generic name: Ibuprofen
Nabumetone Generic name: Nabumetone
Nalfon Generic name: Fenoprofen
Nalfon 200 Generic name: Fenoprofen
Naprelan Generic name: Naproxen
Naprelan 500 Generic name: Naproxen
Naprelan Dose Card Generic name: Naproxen
Naprosyn Generic name: Naproxen
Naproxen Generic name: Naproxen
Naproxen and esomeprazole Generic name: Naproxen And Esomeprazole
NeoProfen Generic name: Ibuprofen Injection
Neoprofen (Ibuprofen Intravenous) Generic name: Ibuprofen
Neoprofen (Ibuprofen lysine Intravenous) Generic name: Ibuprofen Lysine
Nuprin Generic name: Ibuprofen
Orudis Generic name: Ketoprofen
Orudis KT Generic name: Ketoprofen
Oruvail Generic name: Ketoprofen
Oxaprozin Generic name: Oxaprozin
Piroxicam Generic name: Piroxicam
Ponstel Generic name: Mefenamic Acid
Prevacid Naprapac Generic name: Lansoprazole And Naproxen
Proprinal Generic name: Ibuprofen
Qmiiz Generic name: Meloxicam
Q-Profen Generic name: Ibuprofen
Relafen Generic name: Nabumetone
Smart Sense Children's Ibuprofen Generic name: Ibuprofen
Sprix Nasal Spray Generic name: Ketorolac (nasal)
Sulindac Generic name: Sulindac
Tivorbex Generic name: Indomethacin
Tolectin 600 Generic name: Tolmetin
Tolectin DS Generic name: Tolmetin
Tolmetin Generic name: Tolmetin
Toradol Generic name: Ketorolac (oral/injection)
Toradol IV/IM Generic name: Ketorolac
Vimovo Generic name: Esomeprazole And Naproxen
Vivlodex Generic name: Meloxicam
Voltaren Generic name: Diclofenac
Voltaren (Diclofenac Oral) Generic name: Diclofenac
Voltaren-XR Generic name: Diclofenac
Wal-Profen Generic name: Ibuprofen
Zipsor Generic name: Diclofenac
Zorvolex Generic name: Diclofenac

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