Altuviiio
Jeneng umum: Antihemophilic Factor (recombinant), Fc-VWF-XTEN Fusion Protein-ehtl
Kelas obat:
Aneka modifikasi koagulasi
Panganggone Altuviiio
Altuviiio minangka terapi penggantian faktor VIII rekombinan sepisan seminggu sing bisa digunakake dening pasien Hemofilia A kanthi rutin kanggo nyegah pendarahan, utawa digunakake kanggo nambani pendarahan akut. Altuviiio dianggo minangka panggantos faktor koagulasi VIII sing ilang sing dibutuhake pasien hemofilia A kanggo pembekuan getih sing efektif, mula Altuviiio nyuda resiko getihen.
Hemofilia minangka kelainan genetik sing ngrusak kemampuan getih wong. clot bener, iki ndadékaké kanggo getihen gedhe banget lan ora dikarepke. Hemofilia A disebabake dening protein pembekuan sing ilang utawa cacat sing diarani faktor VIII (FVIII), sing tegese getih ora beku nalika perlu. Pasien hemofilia A parah bisa ngalami pendarahan spontan sing berlebihan tanpa sebab sing jelas, iki bisa dadi getihen ing njero awak utawa ing njaba awak. Pasien karo hemofilia A sing luwih entheng mung bisa ngalami pendarahan sing signifikan yen wis operasi utawa sawise tatu abot.
Altuviio diwenehake minangka infus mingguan kanggo pasien hemofilia A, minangka pengganti protein pembekuan faktor VIII sing ilang utawa cacat, kanggo nyuda risiko pendarahan
Altuviiio minangka obat pertama- Terapi penggantian faktor VIII sing disetujoni dening FDA kelas dhuwur sing diwenehake minangka infus intravena sapisan saben minggu. Persetujuan FDA didhukung dening data saka sinau Tahap 3 XTEND-1 (NCT04161495) lan sinau XTEND-Kids (NCT04759131).
Altuviiio efek sisih
Efek samping Altuviiio sing paling umum yaiku:
Sadurunge njupuk Altuviiio
Marang dhokter sampeyan yen sampeyan nandhang reaksi alergi marang Altuviiio wis kepungkur. Aja aja nggunakake Altuviiio amarga sampeyan nandhang reaksi hipersensitivitas sing abot, kalebu anafilaksis, marang Altuviiio utawa bahan ora aktif sing ana ing obat iki.
Meteng
Nyusoni
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Carane nggunakake Altuviiio
Dosis Altuviii kanggo:
Profilaksis rutin (dewasa lan bocah-bocah)
On-demand Perawatan lan Kontrol Episode Pendarahan
Manajemen perioperatif
Kekuwatan Altuviiio sing kasedhiya
Kekuwatan Altuviiio ana ing unit internasional (IU) potensi Faktor VIII.
Altuviiio kasedhiya ing kekuatan ing ngisor iki:
Pènget
Reaksi Hipersensitivitas: Reaksi hipersensitivitas tipe alergi, kalebu anafilaksis, bisa kedadeyan nggunakake Altuviiio. Marang dhokter yen sampeyan duwe pratandha saka reaksi alergi kalebu, sesak ambegan, wheezing, hives, sesak dada, hypotension, lan gatel. Yen sampeyan duwe gejala hipersensitivitas, sampeyan kudu nyetop panggunaan obat iki lan hubungi dokter lan/utawa golek perawatan darurat kanthi cepet.
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