Brompheniramine
Kelas obat: Agen Antineoplastik
Panganggone Brompheniramine
Rhinitis Alergi utawa Alergi Pernafasan Ndhuwur Liyane
Digunakake ing kombinasi tetep karo agen liyane (contone, dextromethorphan, guaifenesin, phenylephrine, pseudoephedrine) kanggo relief rhinorrhea, wahing, lacrimation, mata gatel, oronasopharyngeal. lan/utawa gejala liyane (contone, irung/sinus rame, watuk) sing gegandhèngan karo rhinitis alergi (contone, demam hay) utawa alergi ambegan ndhuwur liyane.
Gunakake preparat kombinasi tetep mung yen gejala sing cocog kanggo saben bahan ana bebarengan.
Selesma Umum
Digunakake ing kombinasi tetep karo agen liyane (contone, phenylephrine, pseudoephedrine) kanggo relief sementara rhinorrhea, wahing, lacrimation, mata gatel, gatel oronasopharyngeal, lan / utawa gejala liyane sing ana gandhengane karo kadhemen umum (contone, hidung macet).
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Carane nggunakake Brompheniramine
Administrasi
Administrasi Lisan
Atur kanthi lisan nganggo panganan, banyu, utawa susu kanggo nyuda iritasi lambung.
Solusi oral brompheniramine maleate: Gunakake mung piranti ukur (contone, penetes, cangkir, sendok) sing dikalibrasi dening pabrikan.
Dosis
Brompheniramine: Kasedhiya minangka brompheniramine maleate; dosis ditulis ing syarat-syarat uyah.
Dexbrompheniramine: Kasedhiya minangka dexprompheniramine maleate; dosis ditulis ing syarat-syarat uyah. Dexbrompheniramine maleate mung kasedhiya ing preparat kombinasi tetep.
Dosis individu miturut respon lan toleransi pasien.
Persediaan kombinasi tetep ora ngidini titrasi dosis individu. Yen digunakake ing kombinasi tetep karo agen liyane (contone, dextromethorphan, guaifenesin, phenylephrine, pseudoephedrine), pilih dosis sing ana ing kisaran terapeutik biasa kanggo saben bahan. Amarga kombinasi lan kekuatan dosis beda-beda kanggo preparat kombinasi tetep, takon label produk pabrikan kanggo dosis sing cocog kanggo persiapan spesifik.
Pasien Anak
Alergi Rhinitis, Alergi Pernafasan Upper Liyane, utawa Common Cold Brompheniramine Maleate OralBocah 2 nganti <6 taun: 1 mg saben 4 jam.
Obat mandiri kanggo bocah umur 6 nganti <12 taun: 2 mg saben 4 jam.
Obat mandiri ing bocah ≥12 taun: 4 mg saben 4 jam.
Dewasa
Rhinitis Alergi, Alergi Pernafasan Upper Liyane, utawa Oral Cold Brompheniramine Maleate OralObat dhewe: 4 mg saben 4 jam.
Batesan Resep
Pasien Anak
Rinitis Alergi, Alergi Pernafasan Upper Liyane, utawa Oral Cold Brompheniramine Maleate OralBocah 2 nganti <6 taun: Maksimum 6 mg ing 24 jam.
Bocah 6 nganti <12 taun: Maksimum 12 mg ing 24 jam. Yen digunakake kanggo ngobati dhewe, mandhegake terapi yen gejala tetep luwih saka 7 dina utawa diiringi demam.
Bocah ≥12 taun: Maksimal 24 mg ing 24 jam. Yen digunakake kanggo ngobati dhewe, mungkasi terapi yen gejala tetep nganti >7 dina utawa diiringi demam.
Dewasa
Rinitis Alergi, Alergi Pernafasan Upper Liyane, utawa Common Cold Brompheniramine Maleate OralMaksimum 24 mg ing 24 jam. Yen digunakake kanggo ngobati dhewe, mungkasi terapi yen gejala tetep nganti >7 dina utawa diiringi demam.
Populasi Khusus
Pasien Geriatrik
Pasien ≥60 taun: Pilih dosis kanthi ati-ati, diwiwiti saka ujung ngisor saka kisaran dosis biasa, amarga nyuda fungsi ati, ginjel, lan / utawa jantung sing gegandhengan karo umur lan penyakit bebarengan lan terapi obat.
Pènget
Kontraindikasi
Pènget/PanandhapPènget
Penyakit-penyakit sing bebarengan
Gunakake kanthi ati-ati ing pasien kanthi peningkatan IOP, asma bronkial, hipertiroidisme, diabetes mellitus, penyakit kardiovaskular (contone, hipertensi, penyakit jantung iskemik), utawa hipertrofi prostat.
Efek SSPRisiko ngantuk. Panganggone depresan CNS liyane bisa uga duwe efek depresan CNS aditif. (Deleng Depresan CNS ing Interaksi lan uga pirsani Saran kanggo Pasien.)
Kamungkinan excitability (utamane ing bocah-bocah). (Deleng Panganggone Pediatrik ing Caution.)
Pancegahan Umum
Efek AntikolinergikKamungkinan efek antikolinergik (contone, tutuk, irung, lan tenggorokan garing banget; disuria; retensi urin). Gunakake kanthi ati-ati, yen kabeh, ing pasien kanthi hipertrofi prostat, obstruksi pyloroduodenal, utawa obstruksi gulu kandung kemih. (Deleng Contraindications ing Cautions.)
Panganggone Kombinasi TetepYen digunakake ing kombinasi tetep karo agen liyane (contone, dextromethorphan, guaifenesin, phenylephrine, pseudoephedrine), nimbang ati-ati, pancegahan, lan kontraindikasi sing digandhengake karo concomitant. agen (s).
Populasi Tertentu
KandhutanKategori C. Gunakake ora dianjurake sajrone trimester katelu amarga ana risiko reaksi abot (contone, kejang) ing neonatus lan bayi durung wayahe.
LaktasiOra dingerteni yen brompheniramine disebarake menyang susu. Mungkasi nyusoni utawa obat amarga ana risiko kanggo bayi sing nyusoni. (Deleng Contraindications ing Cautions.)
Gunakake PediatrikKamungkinan paradoks irritability utawa kasenengan (contone, gelisah, insomnia, tremor, euforia, nervousness, delirium, palpitasi, kejang), utamané ing bocah-bocah.
Brompheniramine maleate: Safety lan khasiat brompheniramine ing kombinasi tetep karo pseudoephedrine lan dextromethorphan ora ditetepake ing bocah-bocah <6 sasi. Kanggo obat mandiri, aja nggunakake brompheniramine ing kombinasi tetep karo phenylephrine ing bocah-bocah <6 taun.
Risiko overdosis lan keracunan (kalebu pati) ing bocah-bocah <2 taun sing nampa preparat OTC sing ngemot antihistamin, penekan batuk, ekspektoran, lan dekongestan irung dhewe utawa ing kombinasi kanggo ngilangi gejala infeksi saluran napas ndhuwur. . Bukti winates khasiat kanggo persiapan kasebut ing klompok umur iki; dosis sing cocog ora ditetepake. Mulane, FDA nyaranake ora nggunakake preparat kasebut ing bocah-bocah <2 taun; safety lan khasiat ing bocah-bocah sing luwih tuwa ing evaluasi. Amarga bocah-bocah umur 2-3 taun uga duwe risiko overdosis lan keracunan, sawetara pabrikan obat batuk lan kadhemen sing ora diresepake oral sarujuk kanggo revisi label produk kanthi sukarela kanggo nyatakake yen preparat kasebut ora bisa digunakake ing bocah-bocah <4 taun. . FDA nyaranake supaya wong tuwa lan pengasuh netepi instruksi dosis lan bebaya ing label produk sing ngiringi persiapan kasebut lan takon karo dokter babagan masalah apa wae. Dokter kudu takon karo caregiver babagan panggunaan obat batuk / kadhemen sing ora diresepake supaya ora overdosis.
Panggunaan GeriatrikBisa tambah risiko kebingungan, pusing, sedasi, hipotensi, hiperexcitability, lan efek antikolinergik (umpamane, tutuk garing, retensi urin. [utamane ing pria]) ing pasien ≥60 taun. (Deleng Pasien Geriatrik miturut Dosis lan Administrasi.)
Efek Samsaya Awon
Sedasi (contone, ngantuk, pusing), stimulasi CNS (contone, gelisah, insomnia, kuatir, tegang, gugup), vertigo, kelemahane, kebingungan, penglihatan kabur, mual , tutuk garing, palpitasi jantung, flushing, tambah thickening saka sekresi bronkial.
Apa obatan liyane bakal mengaruhi Brompheniramine
Obat Spesifik lan Tes Laboratorium
Uji Obat utawa Laboratorium
Interaksi
Komentar
Depresan SSP (alkohol, hipnotik, sedatif, penenang, antidepresan trisiklik)
Kemungkinan depresi CNS aditif
Antidepresan trisiklik ndawakake lan nambah efek antikolinergik saka antihistamin
Aja nggunakake bebarengan
Inhibitor MAO
Inhibitor MAO prolong lan nambah efek antikolinergik saka antihistamin
Kontraindikasi sajrone utawa sajrone 2 minggu terapi MAO-inhibitor
Tes, antigen utawa histamin
Tes tantangan inhalasi nganggo histamin utawa antigen: Kemungkinan nyuda respon tes
Tes kulit antigen: Kemungkinan supresi reaksi wheal lan flare
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- lenvima pi
- empagliflozin-linagliptin
- encourage foundation for enbrel
- qulipta drug interactions