Doxycycline (EENT)
Jeneng merek: Atridox
Kelas obat:
Agen Antineoplastik
Panganggone Doxycycline (EENT)
Periodontitis
Digunakake kanthi lisan kanggo perawatan periodontitis diwasa minangka tambahan kanggo scaling lan root planing kanggo ningkatake gain tingkat lampiran lan nyuda ambane saku.
Digunakake kanthi subgingiva kanggo perawatan periodontitis diwasa kronis kanggo nyuda ambane kanthong, entuk tingkat lampiran klinis, lan nyuda pendarahan sing ana gandhengane karo probing.
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Carane nggunakake Doxycycline (EENT)
Administrasi
Administrasi Lisan
Diwenehake kanthi lisan minangka tablet 20 mg kanggo perawatan tambahan saka periodontitis.
Diombe kaping pindho saben dina paling ora 1 jam sadurunge utawa 2 jam sawise mangan.
Wokake kanthi jumlah sing cukup. Cairan kanggo nyuda resiko iritasi esofagus lan ulkus.
Administrasi Subgingiva
Diwenehake kanthi subgingiva minangka persiapan pelepasan sing luwih dawa menyang kanthong periodontal dening profesional perawatan kesehatan gigi.
Disedhiyakake kanthi komersial minangka kit sing ngemot jarum suntik saka sistem pangiriman polimer cair (jarum suntik A), jarum suntik doksisiklin (jarum suntik B), lan kanula tumpul. Isi 2 syringe kudu dicampur bebarengan sadurunge administrasi. (Deleng Rekonstitusi ing Dosis lan Administrasi.)
Campuran pungkasan katon minangka cairan kenthel kuning pucet nganti kuning; sawise administrasi subgingival menyang kanthong periodontal, cairan kasebut solidifikasi kanggo nyedhiyakake pelepasan doxycycline sing dikontrol sajrone 7 dina.
Saben pasangan jarum suntik mung ditrapake kanggo panggunaan siji.
Administrasi ora mbutuhake anestesi lokal.
Persediaan sing dibebasake luwih cepet diserap utawa diusir kanthi alami lan ora. ora perlu dicopot kanthi manual.
RekonstitusiCampur isi 2 jarum suntik sing dipasangake (sistem pangiriman polimer cair [syringe A] lan bubuk doxycycline [syringe B]) bebarengan sadurunge administrasi.
Copot jarum suntik saka kulkas paling sethithik 15 menit sadurunge nyampur.
Sapasang jarum suntik bebarengan lan suntik isi jarum suntik A menyang jarum suntik B banjur bali menyang jarum suntik A kanggo ngrampungake 1 siklus campuran. Nindakake total 100 siklus pencampuran nggunakake stroke cepet (kira-kira 1 siklus pencampuran per detik).
Yen ora diwenehake langsung, jarum suntik sing ditambah bisa disimpen ing kantong sing bisa ditutup maneh (utawa wadhah kedap udara) ing suhu kamar nganti nganti 3 dina. Sawise panyimpenan kasebut, tindakake 10 siklus pencampuran tambahan sadurunge administrasi.
Sawise nyampur, terus jarum suntik sing digandhengake vertikal nganggo jarum suntik A (dituduhake kanthi garis abang) ing sisih ngisor. Tarik mudhun plunger saka syringe A lan ngidini isi kanggo mili mudhun tong minyak kanggo sawetara detik menyang syringe A. Uncouple syringes lan masang kanula tumpul sing diwenehake ing kit kanggo syringe A. Bend kanula kaya probe periodontal.
Subgingival Teknik AdministrasiNganggo jarum suntik kanthi kanula sing bengkok, posisi ujung kanula cedhak pangkal kantong periodontal lan atur preparat polimer doksisiklin menyang saku nganti campuran tekan ndhuwur margin gingiva. Copot kanula saka kanthong.
Yen dikarepake, preparat kasebut bisa dilebokake ing kanthong periodontal nggunakake piranti dental sing cocog. Celupake pinggir instrumen dental ing banyu sadurunge dikemas kanggo nyegah persiapan saka nempel ing instrumen lan nyepetake koagulasi polimer. Sawise preparasi kasebut ana ing kantong periodontal, netesake sawetara tetes banyu menyang permukaan kanggo mbantu koagulasi polimer. Yen perlu, tambahake polimer doxycycline liyane lan bungkus menyang kantong periodontal nganti kebak.
Sawise administrasi subgingiva rampung, tutup kanthong nganggo balutan periodontal (Coe-Pak) utawa adhesive dental cyanoacrylate.
Konsultasi literatur pabrikan kanggo informasi tambahan babagan persiapan lan administrasi subgingiva polimer doxycycline.
Dosis
Kasedhiya minangka doxycycline hyclate; dosis ditulis ing syarat-syarat doxycycline.
Polymer hyclate doxycycline kanggo administrasi subgingiva: Nalika disiapake kaya sing diarahake (pirsani Reconstitution ing Dosis lan Administrasi), campuran ing syringe ngemot 50 mg doxycycline hyclate (padha karo 42,5 mg doxycycline).
Dewasa
Periodontitis Oral20 mg saben 12 jam (esuk lan sore).
Keamanan >12 sasi perawatan lan khasiat >9 sasi perawatan ora ditetepake.
SubgingivaDosis beda-beda gumantung gumantung babagan ukuran, wangun, lan jumlah kanthong periodontal sing diobati.
Bisa mbaleni perawatan 4 sasi sawise perawatan awal.
Pènget
Kontraindikasi
Pènget/PanandhapPènget
Efek Gigi lan Balung
Aja nganggo tetrasiklin nalika ngembang (contone, meteng, bayi, bocah nganti umur 8 taun); potensial kanggo owah-owahan untu permanen (kuning-abu-abu-coklat) utawa hypoplasia enamel. Paling umum karo panggunaan tetracycline jangka panjang, nanging uga dilapurake sawise nggunakake jangka pendek sing bola-bali.
Tetrasiklin mbentuk kompleks kalsium sing stabil ing jaringan apa wae sing mbentuk balung. Penurunan tingkat pertumbuhan fibula sing bisa dibalekake wis kedadeyan ing bayi prematur sing nampa tetrasiklin oral.
Reaksi Sensitivitas
Reaksi HipersensitivitasReaksi hipersensitivitas, kalebu anafilaksis, purpura anafilaktoid, penyakit serum, urtikaria, angioedema, perikarditis, lan eksaserbasi lupus eritematosus sistemik, dilapurake ing pasien sing nampa fotosensitivitas tetracyclines. Reaksi
Fotosensitivitas, diwujudake minangka reaksi sunburn sing berlebihan ing area awak sing kena sinar srengenge langsung utawa sinar ultraviolet (UV), sing dilapurake ing sawetara pasien sing nampa tetrasiklin.
Mungkasi doksisiklin oral utawa subgingiva ing tandha pisanan eritema kulit.
Pènget/Panandhap Liyane
Pancegahan sing Gegandhengan karo Doksisiklin OralDosis oral sing digunakake kanggo perawatan tambahan periodontitis beda karo sing digunakake kanggo perawatan infeksi. Tambah insiden efek salabetipun, kalebu pangembangan organisme sing tahan, bisa kedadeyan yen luwih saka dosis dianjurake sing digunakake ing pasien karo periodontitis.
Dosis lisan sing digunakake ing perawatan tambahan saka periodontitis ora nyedhiyakake konsentrasi obat sing cukup dhuwur kanggo nyegah. Organisme sing umum digandhengake karo periodontitis diwasa. Tablet 20 mg sing digunakake kanggo perawatan periodontitis ora kudu digunakake kanggo nyuda utawa ngilangi organisme kasebut.
Pancegahan sing Gegandhengan karo Subgingival DoxycyclineOra diteliti ing pasien kanthi cacat periodontal sing abot banget kanthi sisa periodontium sing sithik.
Ora diteliti kanggo digunakake ing regenerasi balung alveolar, minangka persiapan utawa bebarengan karo penempatan implan endosseous (dental) utawa kanggo perawatan implan sing gagal.
Ora diteliti. ing pasien immunocompromised (contone, sing duwe diabetes mellitus utawa infeksi HIV, sing nampa kemoterapi utawa terapi radiasi).
Superinfeksi/KandidiasisKamungkinan overgrowth organisme nonsusceptible, kalebu jamur, ing pasien sing nampa doxycycline oral utawa subgingiva.
Pertumbuhan berlebihan mikroorganisme oportunistik, kayata ragi, ora dilapurake ing studi klinis ngevaluasi doksisiklin oral ing wong diwasa kanthi periodontitis.
Tetrasiklin bisa nambah insidensi kandidiasis vagina.
Gunakake doxycycline oral utawa subgingival kanthi ati-ati ing pasien kanthi riwayat utawa predisposisi kandidiasis oral. Safety lan khasiat ora ditetepake ing pasien karo kandidiasis oral bebarengan.
Populasi Tertentu
KandhutanAja nggunakake tetrasiklin nalika meteng. Yen tetracycline digunakake nalika meteng, kabarake pasien babagan bebaya sing potensial kanggo janin.
Bisa nyebabake cilaka janin yen diwenehake marang wanita ngandhut; efek saka tetracyclines ing tenaga kerja lan pangiriman ora dingerteni.
Doxycycline subgingiva ora dievaluasi ing wanita ngandhut.
LaktasiTetracyclines disebarake menyang susu sawise administrasi lisan. Ora dingerteni manawa doxycycline disebarake menyang susu sawise administrasi subgingiva.
Doxycycline dikontraindikasi ing wanita sing nyusoni. Mungkasi nyusoni utawa obat kasebut.
Panggunaan PediatrikOral: Aja digunakake ing bocah-bocah <8 taun. (Deleng Efek Gigi lan Balung ing Ati-ati.)
Subgingiva: Keamanan lan khasiat ora ditetepake ing pasien pediatrik <18 taun.
Efek Umum sing Sabar
Oral: Sakit sirah, selesma, gejala flu, nyeri untu, gejala GI (diare, mual, dyspepsia), nyeri sendi.
Subgingiva: Sakit sirah ; umum kadhemen; rasa ora nyaman gusi, nyeri utawa perih, kelangan lampiran, utawa ambane kanthong tambah; toothache utawa sensitivitas tekanan; abses periodontal, eksudat, infeksi, drainase, mobilitas ekstrim, utawa suppuration; sensitivitas untu termal.
Apa obatan liyane bakal mengaruhi Doxycycline (EENT)
Interaksi obat sing dilapurake kalebu doksisiklin oral. Ora ana studi interaksi obat formal sing ditindakake kanthi doksisiklin subgingiva.
Obat Spesifik
Obat
Interaksi
Komentar
Antasida (aluminium, kalsium, utawa magnesium)
Penurunan penyerapan doksisiklin
Antikoagulan, oral
Kamungkinan penurunan aktivitas protrombin
Nyetel dosis antikoagulan yen perlu
Antikonvulsan (barbiturat, karbamazepin, fenitoin)
Kemungkinan penurunan paruh doksisiklin
Bismuth subsalicylate
Kemungkinan penurunan penyerapan doksisiklin
Kontrasepsi hormonal
Kemungkinan penurunan efektifitas oral kontrasepsi
Persediaan sing ngemot wesi
Kamungkinan nyuda penyerapan doksisiklin
Methoxyflurane
Toksisitas ginjel fatal sing dilaporake kanthi nggunakake tetrasiklin lan methoxyflurane
Penisilin
Antagonisme sing bisa ditindakake
Aja nggunakake bebarengan
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