Ketorolac (EENT)
Jeneng merek: Acular
Kelas obat:
Agen Antineoplastik , Agen Antineoplastik , Agen Antineoplastik , Agen Antineoplastik
Panganggone Ketorolac (EENT)
Konjungtivitis
Ngilangake sauntara gatel mata amarga konjungtivitis alergi musiman (demam, pollinosis).
Radang Okular Pasca Operasi
Manajemen inflamasi pasca operasi sing ana gandhengane karo ekstraksi katarak.
Nyeri Okular Pasca Operasi
Ngurangi nyeri okular lan kobong/nyengat sawise operasi refraksi kornea lan keratectomy fotorefraktif (PRK).
Ketorolac tromethamine 0,5% larutan ophthalmic tanpa pengawet digunakake kanggo nyuda nyeri okular lan fotofobia sawise operasi refraksi insisi.
Cystoid Macular Edema
Pengobatan, kanthi utawa tanpa terapi kortikosteroid topikal, kanggo nyegah utawa nyuda edema makula cystoid pasca operasi sing ana gandhengane karo ekstraksi katarak† [off-label].
Duwe digunakake kanggo perawatan aktif aphakic utawa pseudophakic cystoid macular edema† [off-label].
Inhibisi Miosis Intraoperatif
Wis digunakake prophylactically sadurunge operasi okular kanggo nyegah utawa nyuda miosis intraoperatif† [off-label].
Related obat
- Abemaciclib (Systemic)
- Acyclovir (Systemic)
- Adenovirus Vaccine
- Aldomet
- Aluminum Acetate
- Aluminum Chloride (Topical)
- Ambien
- Ambien CR
- Aminosalicylic Acid
- Anacaulase
- Anacaulase
- Anifrolumab (Systemic)
- Antacids
- Anthrax Immune Globulin IV (Human)
- Antihemophilic Factor (Recombinant), Fc fusion protein (Systemic)
- Antihemophilic Factor (recombinant), Fc-VWF-XTEN Fusion Protein
- Antihemophilic Factor (recombinant), PEGylated
- Antithrombin alfa
- Antithrombin alfa
- Antithrombin III
- Antithrombin III
- Antithymocyte Globulin (Equine)
- Antivenin (Latrodectus mactans) (Equine)
- Apremilast (Systemic)
- Aprepitant/Fosaprepitant
- Articaine
- Asenapine
- Atracurium
- Atropine (EENT)
- Avacincaptad Pegol (EENT)
- Avacincaptad Pegol (EENT)
- Axicabtagene (Systemic)
- Clidinium
- Clindamycin (Systemic)
- Clonidine
- Clonidine (Epidural)
- Clonidine (Oral)
- Clonidine injection
- Clonidine transdermal
- Co-trimoxazole
- COVID-19 Vaccine (Janssen) (Systemic)
- COVID-19 Vaccine (Moderna)
- COVID-19 Vaccine (Pfizer-BioNTech)
- Crizanlizumab-tmca (Systemic)
- Cromolyn (EENT)
- Cromolyn (Systemic, Oral Inhalation)
- Crotalidae Polyvalent Immune Fab
- CycloSPORINE (EENT)
- CycloSPORINE (EENT)
- CycloSPORINE (Systemic)
- Cysteamine Bitartrate
- Cysteamine Hydrochloride
- Cysteamine Hydrochloride
- Cytomegalovirus Immune Globulin IV
- A1-Proteinase Inhibitor
- A1-Proteinase Inhibitor
- Bacitracin (EENT)
- Baloxavir
- Baloxavir
- Bazedoxifene
- Beclomethasone (EENT)
- Beclomethasone (Systemic, Oral Inhalation)
- Belladonna
- Belsomra
- Benralizumab (Systemic)
- Benzocaine (EENT)
- Bepotastine
- Betamethasone (Systemic)
- Betaxolol (EENT)
- Betaxolol (Systemic)
- Bexarotene (Systemic)
- Bismuth Salts
- Botulism Antitoxin (Equine)
- Brimonidine (EENT)
- Brivaracetam
- Brivaracetam
- Brolucizumab
- Brompheniramine
- Budesonide (EENT)
- Budesonide (Systemic, Oral Inhalation)
- Bulk-Forming Laxatives
- Bupivacaine (Local)
- BuPROPion (Systemic)
- Buspar
- Buspar Dividose
- Buspirone
- Butoconazole
- Cabotegravir (Systemic)
- Caffeine/Caffeine and Sodium Benzoate
- Calcitonin
- Calcium oxybate, magnesium oxybate, potassium oxybate, and sodium oxybate
- Calcium Salts
- Calcium, magnesium, potassium, and sodium oxybates
- Candida Albicans Skin Test Antigen
- Cantharidin (Topical)
- Capmatinib (Systemic)
- Carbachol
- Carbamide Peroxide
- Carbamide Peroxide
- Carmustine
- Castor Oil
- Catapres
- Catapres-TTS
- Catapres-TTS-1
- Catapres-TTS-2
- Catapres-TTS-3
- Ceftolozane/Tazobactam (Systemic)
- Cefuroxime
- Centruroides Immune F(ab′)2
- Cetirizine (EENT)
- Charcoal, Activated
- Chloramphenicol
- Chlorhexidine (EENT)
- Chlorhexidine (EENT)
- Cholera Vaccine Live Oral
- Choriogonadotropin Alfa
- Ciclesonide (EENT)
- Ciclesonide (Systemic, Oral Inhalation)
- Ciprofloxacin (EENT)
- Citrates
- Dacomitinib (Systemic)
- Dapsone (Systemic)
- Dapsone (Systemic)
- Daridorexant
- Darolutamide (Systemic)
- Dasatinib (Systemic)
- DAUNOrubicin and Cytarabine
- Dayvigo
- Dehydrated Alcohol
- Delafloxacin
- Delandistrogene Moxeparvovec (Systemic)
- Dengue Vaccine Live
- Dexamethasone (EENT)
- Dexamethasone (Systemic)
- Dexmedetomidine
- Dexmedetomidine
- Dexmedetomidine
- Dexmedetomidine (Intravenous)
- Dexmedetomidine (Oromucosal)
- Dexmedetomidine buccal/sublingual
- Dexmedetomidine injection
- Dextran 40
- Diclofenac (Systemic)
- Dihydroergotamine
- Dimethyl Fumarate (Systemic)
- Diphenoxylate
- Diphtheria and Tetanus Toxoids
- Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed
- Diroximel Fumarate (Systemic)
- Docusate Salts
- Donislecel-jujn (Systemic)
- Doravirine, Lamivudine, and Tenofovir Disoproxil
- Doxepin (Systemic)
- Doxercalciferol
- Doxycycline (EENT)
- Doxycycline (Systemic)
- Doxycycline (Systemic)
- Doxylamine
- Duraclon
- Duraclon injection
- Dyclonine
- Edaravone
- Edluar
- Efgartigimod Alfa (Systemic)
- Eflornithine
- Eflornithine
- Elexacaftor, Tezacaftor, And Ivacaftor
- Elranatamab (Systemic)
- Elvitegravir, Cobicistat, Emtricitabine, and tenofovir Disoproxil Fumarate
- Emicizumab-kxwh (Systemic)
- Emtricitabine and Tenofovir Disoproxil Fumarate
- Entrectinib (Systemic)
- EPINEPHrine (EENT)
- EPINEPHrine (Systemic)
- Erythromycin (EENT)
- Erythromycin (Systemic)
- Estrogen-Progestin Combinations
- Estrogen-Progestin Combinations
- Estrogens, Conjugated
- Estropipate; Estrogens, Esterified
- Eszopiclone
- Ethchlorvynol
- Etranacogene Dezaparvovec
- Evinacumab (Systemic)
- Evinacumab (Systemic)
- Factor IX (Human), Factor IX Complex (Human)
- Factor IX (Recombinant)
- Factor IX (Recombinant), albumin fusion protein
- Factor IX (Recombinant), Fc fusion protein
- Factor VIIa (Recombinant)
- Factor Xa (recombinant), Inactivated-zhzo
- Factor Xa (recombinant), Inactivated-zhzo
- Factor XIII A-Subunit (Recombinant)
- Faricimab
- Fecal microbiota, live
- Fedratinib (Systemic)
- Fenofibric Acid/Fenofibrate
- Fibrinogen (Human)
- Flunisolide (EENT)
- Fluocinolone (EENT)
- Fluorides
- Fluorouracil (Systemic)
- Flurbiprofen (EENT)
- Flurbiprofen (EENT)
- Flurbiprofen (EENT)
- Flurbiprofen (EENT)
- Fluticasone (EENT)
- Fluticasone (Systemic, Oral Inhalation)
- Fluticasone and Vilanterol (Oral Inhalation)
- Ganciclovir Sodium
- Gatifloxacin (EENT)
- Gentamicin (EENT)
- Gentamicin (Systemic)
- Gilteritinib (Systemic)
- Glofitamab
- Glycopyrronium
- Glycopyrronium
- Gonadotropin, Chorionic
- Goserelin
- Guanabenz
- Guanadrel
- Guanethidine
- Guanfacine
- Haemophilus b Vaccine
- Hepatitis A Virus Vaccine Inactivated
- Hepatitis B Vaccine Recombinant
- Hetlioz
- Hetlioz LQ
- Homatropine
- Hydrocortisone (EENT)
- Hydrocortisone (Systemic)
- Hydroquinone
- Hylorel
- Hyperosmotic Laxatives
- Ibandronate
- Igalmi buccal/sublingual
- Imipenem, Cilastatin Sodium, and Relebactam
- Inclisiran (Systemic)
- Infliximab, Infliximab-dyyb
- Influenza Vaccine Live Intranasal
- Influenza Vaccine Recombinant
- Influenza Virus Vaccine Inactivated
- Inotuzumab
- Insulin Human
- Interferon Alfa
- Interferon Beta
- Interferon Gamma
- Intermezzo
- Intuniv
- Iodoquinol (Topical)
- Iodoquinol (Topical)
- Ipratropium (EENT)
- Ipratropium (EENT)
- Ipratropium (Systemic, Oral Inhalation)
- Ismelin
- Isoproterenol
- Ivermectin (Systemic)
- Ivermectin (Topical)
- Ixazomib Citrate (Systemic)
- Japanese Encephalitis Vaccine
- Kapvay
- Ketoconazole (Systemic)
- Ketorolac (EENT)
- Ketorolac (EENT)
- Ketorolac (EENT)
- Ketorolac (EENT)
- Ketorolac (Systemic)
- Ketotifen
- Lanthanum
- Lecanemab
- Lefamulin
- Lemborexant
- Lenacapavir (Systemic)
- Leniolisib
- Letermovir
- Letermovir
- Levodopa/Carbidopa
- LevoFLOXacin (EENT)
- LevoFLOXacin (Systemic)
- L-Glutamine
- Lidocaine (Local)
- Lidocaine (Systemic)
- Linezolid
- Lofexidine
- Loncastuximab
- Lotilaner (EENT)
- Lotilaner (EENT)
- Lucemyra
- Lumasiran Sodium
- Lumryz
- Lunesta
- Mannitol
- Mannitol
- Mb-Tab
- Measles, Mumps, and Rubella Vaccine
- Mecamylamine
- Mechlorethamine
- Mechlorethamine
- Melphalan (Systemic)
- Meningococcal Groups A, C, Y, and W-135 Vaccine
- Meprobamate
- Methoxy Polyethylene Glycol-epoetin Beta (Systemic)
- Methyldopa
- Methylergonovine, Ergonovine
- MetroNIDAZOLE (Systemic)
- MetroNIDAZOLE (Systemic)
- Miltown
- Minipress
- Minocycline (EENT)
- Minocycline (Systemic)
- Minoxidil (Systemic)
- Mometasone
- Mometasone (EENT)
- Moxifloxacin (EENT)
- Moxifloxacin (Systemic)
- Nalmefene
- Naloxone (Systemic)
- Natrol Melatonin + 5-HTP
- Nebivolol Hydrochloride
- Neomycin (EENT)
- Neomycin (Systemic)
- Netarsudil Mesylate
- Nexiclon XR
- Nicotine
- Nicotine
- Nicotine
- Nilotinib (Systemic)
- Nirmatrelvir
- Nirmatrelvir
- Nitroglycerin (Systemic)
- Ofloxacin (EENT)
- Ofloxacin (Systemic)
- Oliceridine Fumarate
- Olipudase Alfa-rpcp (Systemic)
- Olopatadine
- Omadacycline (Systemic)
- Osimertinib (Systemic)
- Oxacillin
- Oxymetazoline
- Pacritinib (Systemic)
- Palovarotene (Systemic)
- Paraldehyde
- Peginterferon Alfa
- Peginterferon Beta-1a (Systemic)
- Penicillin G
- Pentobarbital
- Pentosan
- Pilocarpine Hydrochloride
- Pilocarpine, Pilocarpine Hydrochloride, Pilocarpine Nitrate
- Placidyl
- Plasma Protein Fraction
- Plasminogen, Human-tmvh
- Pneumococcal Vaccine
- Polymyxin B (EENT)
- Polymyxin B (Systemic, Topical)
- PONATinib (Systemic)
- Poractant Alfa
- Posaconazole
- Potassium Supplements
- Pozelimab (Systemic)
- Pramoxine
- Prazosin
- Precedex
- Precedex injection
- PrednisoLONE (EENT)
- PrednisoLONE (Systemic)
- Progestins
- Propylhexedrine
- Protamine
- Protein C Concentrate
- Protein C Concentrate
- Prothrombin Complex Concentrate
- Pyrethrins with Piperonyl Butoxide
- Quviviq
- Ramelteon
- Relugolix, Estradiol, and Norethindrone Acetate
- Remdesivir (Systemic)
- Respiratory Syncytial Virus Vaccine, Adjuvanted (Systemic)
- RifAXIMin (Systemic)
- Roflumilast (Systemic)
- Roflumilast (Topical)
- Roflumilast (Topical)
- Rotavirus Vaccine Live Oral
- Rozanolixizumab (Systemic)
- Rozerem
- Ruxolitinib (Systemic)
- Saline Laxatives
- Selenious Acid
- Selexipag
- Selexipag
- Selpercatinib (Systemic)
- Sirolimus (Systemic)
- Sirolimus, albumin-bound
- Smallpox and Mpox Vaccine Live
- Smallpox Vaccine Live
- Sodium Chloride
- Sodium Ferric Gluconate
- Sodium Nitrite
- Sodium oxybate
- Sodium Phenylacetate and Sodium Benzoate
- Sodium Thiosulfate (Antidote) (Systemic)
- Sodium Thiosulfate (Protectant) (Systemic)
- Somatrogon (Systemic)
- Sonata
- Sotorasib (Systemic)
- Suvorexant
- Tacrolimus (Systemic)
- Tafenoquine (Arakoda)
- Tafenoquine (Krintafel)
- Talquetamab (Systemic)
- Tasimelteon
- Tedizolid
- Telotristat
- Tenex
- Terbinafine (Systemic)
- Tetrahydrozoline
- Tezacaftor and Ivacaftor
- Theophyllines
- Thrombin
- Thrombin Alfa (Recombinant) (Topical)
- Timolol (EENT)
- Timolol (Systemic)
- Tixagevimab and Cilgavimab
- Tobramycin (EENT)
- Tobramycin (Systemic)
- TraMADol (Systemic)
- Trametinib Dimethyl Sulfoxide
- Trancot
- Tremelimumab
- Tretinoin (Systemic)
- Triamcinolone (EENT)
- Triamcinolone (Systemic)
- Trimethobenzamide
- Tucatinib (Systemic)
- Unisom
- Vaccinia Immune Globulin IV
- Valoctocogene Roxaparvovec
- Valproate/Divalproex
- Valproate/Divalproex
- Vanspar
- Varenicline (Systemic)
- Varenicline (Systemic)
- Varenicline Tartrate (EENT)
- Vecamyl
- Vitamin B12
- Vonoprazan, Clarithromycin, and Amoxicillin
- Wytensin
- Xyrem
- Xywav
- Zaleplon
- Zirconium Cyclosilicate
- Zolpidem
- Zolpidem (Oral)
- Zolpidem (Oromucosal, Sublingual)
- ZolpiMist
- Zoster Vaccine Recombinant
- 5-hydroxytryptophan, melatonin, and pyridoxine
Carane nggunakake Ketorolac (EENT)
Administrasi
Administrasi Oftalmik
Olesake ing mripat minangka solusi ophthalmic.
Singkirake kontaminasi wadhah solusi.
Aja menehi nalika nganggo lensa kontak.
Solusi tanpa pengawet mung kanggo siji utawa loro mata; gunakake sanalika sawise mbukak lan mbuwang bagean sing ora digunakake sanalika sawise administrasi.
Wis diwenehake kanthi aman karo obat ophthalmic liyane (contone, antibiotik, β-blockers, inhibitor anhydrase karbonat, sikloplegik, mydriatics).
Dosis
Kasedhiya minangka ketorolac tromethamine; dosis ditulis ing syarat-syarat uyah.
Pasien Anak
Konjungtivitis OphthalmicBocah ≥3 taun: 1 tetes (250 mg) larutan 0,5% ing mripat sing kena pengaruh 4 kali dina.
Inflamasi Okular Pasca OperasiBocah ≥3 taun: 1 tetes (250 mcg) saka solusi 0,5% ing mripat (s) ngalami operasi 4 kaping saben dina wiwit 24 jam sawise operasi lan biasane terus kanggo 2 minggu sawise operasi.
Nyeri Okular Pasca OperasiBocah umur ≥3 taun nglakoni operasi refraktif insisi okular: 1 tetes (250 mcg) saka larutan 0,5% tanpa pengawet 4 kali dina ing mripat (s) sing nglakoni operasi kaya sing dibutuhake nganti 3 dina sawise operasi.
Bocah ≥3 taun ngalami operasi refraksi kornea: 1 tetes (200 mcg) larutan 0,4% kaping 4 dina ing mripat. ) sing nglakoni operasi kaya sing dibutuhake nganti 4 dina sawise operasi.
Dewasa
Konjungtivitis Ophthalmic1 tetes (250 mg) larutan 0,5% ing mripat sing kena pengaruh 4 kali dina.
Inflamasi Okular Pasca Operasi1 tetes (250 mcg) larutan 0,5% ing mripat sing lagi dioperasi 4 kali saben dina wiwit 24 jam sawise operasi lan biasane diterusake nganti 2 minggu sawise operasi.
Ophthalmic Nyeri Okular Pasca OperasiPasien sing ngalami operasi refraksi insisi okular: 1 tetes (250 mcg) larutan 0,5% tanpa pengawet 4 kali dina ing mripat sing dioperasi yen perlu nganti 3 dina sawise operasi .
Pasien sing nglakoni operasi refraksi kornea: 1 tetes (200 mcg) larutan 0,4% kaping 4 dina ing mripat (s) sing dioperasi kaya sing dibutuhake nganti 4 dina sawise operasi.
Cystoid Macular Edema Pascaoperasi Cystoid Macular Edema† [off-label] Oftalmik1-2 tetes (250-500 mcg) saka solusi 0,5% ing mripat (s) ngalami operasi saben 6-8 jam wiwit 24 jam sadurunge kanggo surgery lan terus kanggo 3-4 minggu sawise surgery.
Edema Macular Aphakic utawa Pseudophakic Cystoid Kronis† [off-label] Oftalmik1-2 tetes (250-500 mcg) saka solusi 0,5% ing mripat sing kena pengaruh 4 kali saben dina kanggo 2-3 wulan.
Pènget
Contraindications
Hipersensitivitas sing dikenal kanggo tromethamine ketorolac utawa bahan apa wae ing formulasi.
Pènget/PanandhapPènget
Efek Hematologi
Bisa nyandhet agregasi platelet lan ndawakake wektu getihen.
Bisa nambah getihen (contone, hyphemas) saka jaringan okular ing pasien sing nglakoni operasi okular.
Gunakake kanthi ati-ati ing pasien kanthi tendensi pendarahan sing ndasari utawa ing wong sing nampa obat-obatan sing dikenal bisa nambah wektu getihen.
Reaksi Sensitivitas
Sensitivitas silangKamungkinan sensitivitas silang karo aspirin, turunan asam phenylacetic, lan NSAIA liyane. Gunakake kanthi ati-ati ing pasien kanthi riwayat hipersensitifitas kanggo obat kasebut.
Panandhap Umum
Komplikasi Penyembuhan LukaKamungkinan penyembuhan tatu sing alon utawa telat; bisa uga potentiated karo administrasi concomitant NSAIAs topikal utawa kortikosteroid topikal. (Deleng Obat Spesifik ing Interaksi.)
Efek OkularPanganggone bisa nyebabake keratitis. Ing pasien sing rentan, panggunaan sing terus-terusan bisa nyebabake karusakan epitel, penipisan kornea, erosi, ulkus, utawa perforasi, sing bisa ngancam penglihatan.
Yen ana manifestasi kerusakan epitel kornea, mandheg langsung lan ngawasi kesehatan kornea kanthi rapet.
Tambah risiko efek kornea sing ngancam pandeleng, efek kornea sing ora becik ing pasien kanthi operasi okular sing rumit, denervasi kornea, cacat epitel kornea, diabetes mellitus, penyakit permukaan okular (contone, sindrom mata garing), rheumatoid arthritis, utawa baleni. operasi okular ing wektu sing cendhak; nggunakake kanthi ati-ati ing pasien kasebut.
Gunakake >24 jam sadurunge operasi utawa > 14 dina sawise operasi bisa nyebabake utawa nambah efek kornea sing ala.
Populasi Tertentu
KandhutanKategori C. Aja nggunakake ing trimester katelu amarga kemungkinan penutupan duktus arteriosus durung wayahe.
LaktasiDistribusi menyang susu sawise administrasi sistemik. Ati-ati yen digunakake ing wanita nursing.
Panggunaan PediatrikKeslametan lan khasiat ora ditetepake ing bocah-bocah <3 taun.
Panggunaan GeriatrikOra ana bedane signifikan ing safety lan khasiat relatif kanggo wong diwasa enom.
Efek Umum sing Sabar
Ocular stinging and burning.
Apa obatan liyane bakal mengaruhi Ketorolac (EENT)
Ora ana studi interaksi obat resmi nganti saiki.
Obat Spesifik
Obat
Interaksi
Komentar
Kortikosteroid, oftalmik
Efek aditif sing bisa ditindakake kanggo nundha penyembuhan tatu
Aktivitas anti-inflamasi okular aditif
Penggunaan bebarengan bisa nambah potensial komplikasi penyembuhan tatu
Potensi efek aditif sing digunakake kanggo kauntungan terapeutik
Disclaimer
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