Minocycline (Systemic)
Kelas obat: Agen Antineoplastik
Panganggone Minocycline (Systemic)
Infeksi Saluran Pernafasan
Pengobatan infeksi saluran pernapasan sing disebabake dening Mycoplasma pneumoniae.
Pengobatan infeksi saluran pernapasan sing disebabake dening Haemophilus influenzae, Streptococcus pneumoniae, utawa Klebsiella. Mung bisa digunakake kanggo perawatan infeksi sing disebabake dening bakteri kasebut nalika tes kerentanan in vitro nuduhake organisme kasebut rentan.
Infeksi Acinetobacter
Alternatif kanggo imipenem utawa meropenem kanggo perawatan infeksi sing disebabake dening Acinetobacter.
Kukul
Pengobatan tambahan kanggo kukul inflamasi moderat nganti abot. Ora dituduhake kanggo perawatan kukul non-inflamasi.
Actinomycosis
Pengobatan actinomycosis sing disebabake dening Actinomyces israelii; tetrasiklin oral (biasane doxycycline utawa tetracycline) digunakake minangka tindak lanjut sawise penisilin parenteral awal G.
Amebiasis
Tambahan amebisida kanggo perawatan amebiasis usus akut. Tetrasiklin ora kalebu ing rekomendasi saiki kanggo perawatan amebiasis sing disebabake dening Entamoeba.
Anthrax
Alternatif kanggo doxycycline kanggo postexposure prophylaxis kanggo nyuda kedadeyan utawa progresi penyakit sawise dicurigai utawa dikonfirmasi paparan spora Bacillus anthracis aerosol (anthrax inhalasi). Obat pilihan awal kanggo profilaksis kasebut yaiku ciprofloxacin utawa doxycycline; doxycycline minangka tetracycline sing disenengi amarga gampang administrasi lan kabukten khasiat ing studi monyet.
Alternatif kanggo doxycycline kanggo perawatan anthrax inhalasi nalika regimen parenteral ora kasedhiya (contone, masalah pasokan utawa logistik amarga akeh individu mbutuhake perawatan ing setelan korban massal). Regimen parenteral macem-macem obat (ciprofloxacin utawa doxycycline lan 1 utawa 2 anti-infèksi liyane sing diprediksi efektif) luwih disenengi kanggo perawatan anthrax inhalasi sing kedadeyan minangka akibat saka spora anthrax ing konteks perang biologis utawa bioterorisme.
Infeksi Bartonella
Pengobatan bartonellosis sing disebabake dening bacilliformis Bartonella.
Brucellosis
Pengobatan brucellosis; tetracyclines (biasane doxycycline utawa tetracycline) dianggep minangka obat pilihan. Tetrasiklin digunakake bebarengan karo anti-infèksi liyane (contone, streptomycin utawa gentamicin lan/utawa rifampisin), utamane kanggo infeksi abot utawa nalika ana komplikasi (contone, endokarditis, meningitis, osteomyelitis).
Infeksi Campylobacter
Nambani infeksi sing disebabake Campylobacter. Tetracyclines (biasane doxycycline) minangka alternatif, dudu obat pilihan kanggo C. jejuni.
Chancroid
Pengobatan chancroid sing disebabake dening Haemophilus ducreyi. Ora kalebu ing rekomendasi CDC kanggo perawatan chancroid.
Infeksi Chlamydia
Pengobatan infeksi uretra, endoserviks, utawa rektum sing ora rumit sing disebabake dening Chlamydia trachomatis. Doxycycline minangka tetrasiklin sing disenengi kanggo perawatan infèksi kasebut, kalebu perawatan presumptive infèksi klamidia ing pasien gonore.
Pengobatan trachoma lan konjungtivitis inklusi sing disebabake C. trachomatis. Coba yen anti-infèksi ora bisa ngilangi C. trachomatis ing kabeh kasus trachoma kronis.
Pengobatan lymphogranuloma venereum (infeksi genital, inguinal, utawa anorektal) sing disebabake dening C. trachomatis. Doxycycline minangka tetrasiklin sing disenengi kanggo infeksi kasebut.
Pengobatan psittacosis (ornithosis) sing disebabake dening C. psittaci. Doxycycline lan tetracycline minangka obat pilihan. Kanggo perawatan awal pasien sing lara parah, gunakake IV doxycycline.
Infeksi Clostridium
Alternatif kanggo perawatan infeksi sing disebabake Clostridium. Tetrasiklin minangka alternatif kanggo metronidazole utawa penisilin G kanggo perawatan tambahan infeksi C. tetani.
Infeksi Enterobacteriaceae
Pengobatan infeksi sing disebabake dening Escherichia coli, Enterobacter aerogenes, Klebsiella, utawa Shigella sing rentan. Mung kudu digunakake kanggo perawatan infeksi sing disebabake dening bakteri gram-negatif umum iki nalika anti-infèksi liyane sing cocog dikontraindikasi utawa ora efektif lan nalika tes kerentanan in vitro nuduhake organisme kasebut rentan.
Infeksi Fusobacterium
Alternatif kanggo penisilin G kanggo perawatan infeksi sing disebabake Fusobacterium fusiforme (infèksi Vincent).
Gonorrhea lan Infeksi Gegandhengan
Alternatif kanggo perawatan gonore sing ora rumit (kalebu uretritis) sing disebabake dening Neisseria gonorrhoeae sing rentan. Tetrasiklin dianggep minangka terapi sing ora cukup lan ora dianjurake dening CDC kanggo perawatan gonore.
Granuloma Inguinale (Donovanosis)
Pengobatan granuloma inguinale (donovanosis) sing disebabake dening Calymmatobacterium granulomatis. Doxycycline minangka tetrasiklin sing disaranake minangka obat pilihan dening CDC.
Infeksi Listeria
Alternatif kanggo perawatan listeriosis sing disebabake Listeria monocytogenes. Ora biasane dianggep minangka obat pilihan utawa alternatif kanggo infeksi kasebut.
Malaria
Tetrasiklin liyane (doksisiklin) digunakake kanggo nyegah malaria; data ora cukup kanggo ngevaluasi khasiat minocycline kanggo nyegah malaria. CDC nyaranake supaya individu sing nampa terapi minocycline jangka panjang (contone, kanggo kukul) sing uga mbutuhake profilaksis malaria doxycycline kudu nyetop minocycline 1-2 dina sadurunge lelungan lan miwiti doxycycline kanggo profilaksis kasebut; minocycline bisa diwiwiti maneh sawise profilaksis malaria doxycycline rampung.
Infeksi Mycobacterial
Alternatif kanggo digunakake ing regimen macem-macem obat kanggo perawatan kusta multibacillary† [off-label]. WHO nyaranake minocycline minangka alternatif kanggo regimen kusta multibacillary ing pasien sing ora bakal nampa utawa ora bisa ngidinke clofazimine lan nalika rifampisin ora bisa digunakake amarga efek salabetipun, penyakit intercurrent (contone, hepatitis kronis), utawa infèksi karo Mycobacterium leprae tahan rifampisin.
Komponèn saka regimen obat (ROM) basis rifampisin siji dosis kanggo perawatan kusta paucibacillary lesi tunggal† [off-label] (yaiku, lesi kulit siji kanthi mundhut sensasi sing jelas nanging tanpa keterlibatan batang saraf). Regimen ROM saka rifampisin dosis tunggal, ofloxacin dosis tunggal, lan minocycline dosis tunggal dianjurake dening WHO minangka regimen alternatif sing bisa ditampa lan efektif biaya ing program antileprosi sing wis ndeteksi akeh pasien (contone, luwih saka 1000 saben taun) kanthi kusta paucibacillary lesi tunggal.
Pengobatan infeksi kulit sing disebabake dening M. marinum; tamba pilihan.
Infeksi Neisseria meningitidis
Eliminasi kereta nasofaring Neisseria meningitidis. CDC lan AAP nyaranake nggunakake rifampisin, ceftriaxone, utawa ciprofloxacin kanggo operator kasebut lan ora nyaranake nggunakake minocycline maneh.
Ora bisa digunakake kanggo perawatan infeksi sing disebabake dening N. meningitidis.
Nocardiosis
Tetrasiklin minangka alternatif kanggo co-trimoxazole kanggo perawatan nocardiosis† [off-label] sing disebabake dening Nocardia.
Uretritis Nononococcal
Pengobatan uretritis nongonococcal (NGU) sing disebabake dening Ureaplasma urealyticum, C. trachomatis, utawa Mycoplasma. Doxycycline biasane dadi tetracycline pilihan kanggo NGU.
Coba dipikirake manawa sawetara kasus uretritis berulang sawise perawatan bisa disebabake dening U. urealyticum sing tahan tetrasiklin.
Wewelak
Pengobatan wabah sing disebabake dening Yersinia pestis. Regimen pilihan yaiku streptomycin utawa gentamicin; alternatif yaiku doxycycline, tetracycline, ciprofloxacin, utawa chloramphenicol.
Demam Kambuh
Pengobatan demam kambuh sing disebabake dening Borrelia recurrentis. Tetrasiklin minangka obat pilihan.
Rheumatoid Arthritis
Pengobatan rheumatoid arthritis† [off-label]. Salah siji saka sawetara obat antireumatik modifikasi penyakit (DMARDs) sing bisa digunakake nalika terapi DMARD cocok.
Infeksi Rickettsial
Pengobatan infeksi rickettsial kalebu mriyang Rocky Mountain, demam typhus lan grup typhus, demam Q, rickettsialpox, lan demam kutu sing disebabake dening Rickettsiae. Doxycycline minangka obat pilihan kanggo umume infeksi rickettsial.
Infeksi Stenotrophomonas maltophilia
Pengobatan infeksi sing disebabake dening Stenotrophomonas maltophilia† [off-label]. Alternatif kanggo co-trimoxazole.
Syphilis
Alternatif kanggo penisilin G kanggo perawatan sifilis primer, sekunder, laten, utawa tersier (dudu neurosifilis) ing wong diwasa lan remaja sing ora ngandhut sing hipersensitif marang penisilin. Doxycycline lan tetracycline minangka tetrasiklin sing disenengi ing pasien sing hipersensitif marang penisilin. Gunakake tetrasiklin mung yen kepatuhan lan tindak lanjut bisa dipesthekake amarga khasiat ora didokumentasikake kanthi apik.
Tularemia
Pengobatan tularemia sing disebabake dening Francisella tularensis. Tetracyclines (biasane doxycycline) dianggep alternatif kanggo streptomycin (utawa gentamicin); risiko kambuh lan gagal perawatan primer bisa uga luwih dhuwur tinimbang karo aminoglikosida.
Infeksi Vibrio
Pengobatan kolera sing disebabake dening Vibrio cholerae. Doxycycline lan tetracycline minangka obat pilihan; digunakake minangka tambahan kanggo panggantos cairan lan elektrolit ing penyakit moderat nganti abot.
Yaws
Alternatif kanggo penisilin G kanggo perawatan yaws disebabake Treponema pertenue.
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Carane nggunakake Minocycline (Systemic)
Administrasi
Administrasi kanthi lisan. Wis diwenehake kanthi infus IV, nanging preparat parenteral ora kasedhiya maneh ing AS.
Administrasi Oral
Tablet lan kapsul sing diisi pelet kudu diwenehake paling ora 1 jam sadurunge utawa 2 jam sawise. dhaharan. Kapsul bisa diwenehake kanthi utawa tanpa panganan.
Kasedhiya kapsul, kapsul sing diisi pelet, lan tablet kanthi jumlah cairan sing cukup kanggo nyuda resiko iritasi esophagus lan ulcerasi.
Kapsul sing diisi pelet kudu ditelan wutuh.
Dosis
Kasedhiya minangka minocycline hydrochloride; dosis ditulis ing syarat-syarat minocycline.
Pasien Pediatrik
Dosis Umum Pediatrik OralBocah >8 taun: 4 mg/kg wiwitane diterusake 2 mg/kg saben 12 jam.
Infeksi Mycobacterial Lepra† LisanBocah umur 5-14 taun: kanggo perawatan kusta paucibacillary lesi tunggal† ing kelompok pasien tartamtu, WHO nyaranake regimen ROM dosis siji sing kalebu dosis tunggal 300 mg. rifampisin, dosis tunggal ofloxacin 200 mg, lan minocycline dosis 50 mg siji.
Bocah <5 taun: WHO nyaranake supaya dosis sing disesuaikan saben obat ing dosis tunggal. regimen dosis ROM digunakake.
Dewasa
Dosis Dewasa Umum Oral200 mg wiwitane disusul 100 mg saben 12 jam.
Utawa, yen dosis luwih kerep luwih disenengi, 100-200 mg wiwitane diterusake 50 mg 4 kali dina.
Jerawat Oral50 mg 1-3 kaping saben dina.
Infeksi Chlamydial Infeksi Uretra, Endoserviks, utawa Rektal Ora Rumit Oral100 mg saben 12 jam sing diwenehake kanggo ≥7 dina.
Gonorrhea lan Infèksi sing Gegandhengan Gonorrhea Tanpa Rumit (kajaba Urethritis utawa Anorektal ing Pria) Oral200 mg wiwitane diterusake 100 mg saben 12 jam sing diwenehake kanggo ≥ 4 dina; kultur tindak lanjut kudu ditindakake sajrone 2-3 dina sawise terapi rampung.
Ora dianjurake maneh kanggo gonore dening CDC utawa pakar liyane.
Uretritis Gonococcal ing Wong Oral100 mg saben 12 jam diwenehi kanggo 5 dina.
Ora dianjurake maneh kanggo gonore dening CDC utawa pakar liyane.
Infeksi Mikobakteri Kusta† LisanKanggo perawatan kusta multibacillary† ing wong sing ora bisa nampa rifampisin amarga efek sing mbebayani, penyakit intercurrent ( contone, hepatitis kronis), utawa infeksi karo M. leprae sing tahan rifampisin, WHO nyaranake administrasi regimen clofazimine (50 mg saben dina), ofloxacin (400 mg saben dina), lan minocycline (100 mg saben dina) sing diwenehake sajrone 6 sasi, Diterusake kanthi regimen clofazimine (50 mg saben dina) lan minocycline (100 mg saben dina) diwenehi paling sethithik 18 wulan tambahan.
Kanggo perawatan kusta multibacillary ing wong diwasa sing ora bakal nampa utawa ora bisa ngidinke clofazimine, WHO nyaranake administrasi regimen ROM sapisan saben wulan sing kalebu rifampisin (600 mg sapisan saben wulan), ofloxacin (400 mg sapisan saben wulan). ), lan minocycline (100 mg sapisan saben wulan) diwenehi kanggo 24 sasi.
Kanggo perawatan kusta paucibacillary lesi tunggal† ing kelompok pasien tartamtu, WHO nyaranake regimen ROM dosis tunggal sing kalebu dosis rifampisin 600 mg tunggal, dosis ofloksasin 400 mg tunggal, lan minocycline dosis tunggal 100 mg.
Infeksi Mycobacterium marinum OralProdusen nyatakake dosis optimal durung ditetepake, nanging 100 mg saben 12 jam kanggo 6-8 minggu wis efektif.
100 mg kaping pindho saben dina kanggo ≥3 sasi dianjurake dening ATS kanggo perawatan infèksi kulit. Pangobatan minimal 4-6 minggu biasane dibutuhake kanggo nemtokake manawa infeksi kasebut nanggapi.
Infeksi Neisseria meningitidis Infeksi N. meningitidis Pembawa Oral100 mg saben 12 jam sing diwenehake sajrone 5 dina.
Nocardiosis† Oral200 mg wiwitane disusul 100 mg saben 12 jam sing diwènèhaké kanggo 12–18 sasi.
Uretritis Nononoccocal Oral100 mg saben 12 jam diwenehi ≥ 7 dina.
Rheumatoid Arthritis† Oral100 mg kaping pindho saben dina. Mupangat bisa katon sajrone 1-3 sasi.
Sifilis Oral200 mg wiwitane disusul 100 mg saben 12 jam sing diwenehake sajrone 10-15 dina. Disaranake tindak lanjut lan tes laboratorium.
Infeksi Vibrio Kolera Oral200 mg wiwitane disusul 100 mg saben 12 jam sing diwenehake kanggo 2-3 dina.
Batesan Resep
Pasien Anak
OralAja ngluwihi dosis diwasa biasa.
Populasi Khusus
Gagal Ginjal
Data ora cukup kanggo menehi rekomendasi babagan penyesuaian dosis. Dosis ora kudu ngluwihi 200 mg saben dina kanggo pasien sing duwe fungsi ginjel cacat.
Pènget
Kontraindikasi
Pènget/PanandhapPènget
Efek Gigi lan Balung
Gunakake nalika tuwuh waos (contone, meteng, bocah-bocah <8 taun) bisa nyebabake owah-owahan warna kuning-abu-abu nganti coklat permanen ing untu lan hypoplasia enamel. Efek paling umum sawise panggunaan jangka panjang, nanging bisa uga kedadeyan sawise nggunakake jangka pendek sing bola-bali.
Tetrasiklin mbentuk kompleks kalsium sing stabil ing jaringan apa wae sing mbentuk balung. Penurunan tingkat pertumbuhan fibula sing bisa dibalik wis kedadeyan ing prematur sing nampa tetrasiklin.
Panganggone ora dianjurake kanggo bocah-bocah <8 taun kajaba obat-obatan liyane sing cocog ora efektif utawa kontraindikasi utawa kajaba keuntungan ing indikasi tartamtu (contone, anthrax) luwih gedhe tinimbang risiko. (Deleng Panganggone Pediatrik ing Ati-ati.)
Morbiditas Janin/NeonatalPanaliten kewan nuduhake kemungkinan keracunan janin (contone, retardasi perkembangan balung) lan embriotoksik. Yen digunakake nalika meteng utawa yen pasien ngandhut nalika nampa minocycline, pasien kudu dilaporake babagan bebaya sing bisa nyebabake janin. (Deleng Pregnancy ing Cautions.)
Efek Sistem SarafKemungkinan efek CNS sing ora becik (muter, pusing, vertigo) sing bisa ngrusak kemampuan kanggo nyopir kendaraan utawa ngoperasikake mesin sing mbebayani. Reaksi vestibular dumadi luwih kerep karo minocycline tinimbang karo tetrasiklin liyane. Gejala bisa ilang sajrone terapi lan biasane ilang kanthi cepet nalika obat kasebut mandheg.
Hipertensi intrakranial jinak (pseudotumor cerebri) ing wong diwasa sing dilapurake karo tetrasiklin; biasane diwujudake minangka sirah lan sesanti burem. Fontanel bulging dilaporake ing bayi. Efek biasane rampung nalika obat dihentikan, nanging ana kemungkinan terusan permanen.
Efek RenalTetrasiklin duweni efek antianabolik lan bisa nambah BUN.
Ing pasien kanthi fungsi ginjel cacat, konsentrasi minocycline serum sing dhuwur bisa nyebabake azotemia, hiperfosfatemia, lan acidosis. Akumulasi obat sing berlebihan lan kemungkinan keracunan ati bisa kedadeyan yen dosis biasa digunakake ing pasien sing duwe fungsi ginjel cacat. (Deleng Gagal Ginjal ing Dosis lan Administrasi.)
Pemantauan LaboratoriumPriksa sacara periodik fungsi sistem organ, kalebu ginjel, ati lan hematopoietik, sajrone terapi jangka panjang.
Reaksi Sensitivitas
Reaksi FotosensitivitasFotosensitivitas, diwujudake kanthi reaksi sunburn sing berlebihan, dilapurake karo tetrasiklin.
Reaksi fotosensitivitas bisa berkembang sajrone sawetara menit nganti pirang-pirang jam sawise cahya srengenge lan biasane tetep 1-2 dina sawise mandhegake obat kasebut. Umume reaksi amarga akumulasi tetrasiklin ing kulit lan sifate fototoksik; reaksi fotoalergi uga bisa kedaden.
Mateni tamba ing bukti pisanan eritema kulit.
Reaksi HipersensitivitasUrticaria, edema angioneurotik, polyarthralgia, anafilaksis, purpura anafilaktoid, pericarditis, exacerbation saka sistemik lupus erythematosus lan, jarang, infiltrat paru karo eosinofilia wis dilaporake. Sindrom kaya lupus transien lan reaksi kaya penyakit serum uga wis dilaporake.
Pancegahan Umum
HepatotoksisitasHepatotoksisitas wis dilaporake. Gunakake kanthi ati-ati ing pasien sing nandhang gangguan fungsi ati lan sing nampa obat hepatotoksik liyane.
SuperinfeksiKamungkinan muncul lan tuwuhing bakteri utawa jamur sing ora rentan. Mungkasi obat kasebut lan tindakake terapi sing cocog yen ana superinfeksi.
Pamilihan lan Panggunaan Anti-infèksiKanggo nyuda pangembangan bakteri sing tahan obat lan njaga efektifitas minocycline lan antibakteri liyane, gunakake mung kanggo perawatan utawa nyegah infeksi sing kabukten utawa dicurigai banget disebabake dening bakteri sing rentan.
Nalika milih utawa ngowahi terapi anti-infèksi, gunakake asil kultur lan tes kerentanan in vitro. Yen ora ana data kasebut, nimbang epidemiologi lokal lan pola kerentanan nalika milih anti-infèksi kanggo terapi empiris.
Amarga akeh galur Acinetobacter, Bacteroides, Enterobacter, E. coli, Klebsiella, Shigella, S. pyogenes (grup A streptococci β-hemolytic), S. pneumoniae, enterococci, lan streptococci α-hemolytic sing tahan. kanggo tetracyclines (kalebu minocycline), tes kerentanan in vitro kudu ditindakake yen obat kasebut digunakake kanggo perawatan infeksi sing disebabake dening bakteri kasebut.
Incision lan drainase utawa prosedur bedhah liyane kudu ditindakake bebarengan karo terapi minocycline yen dituduhake.
Populasi Spesifik
KandhutanKategori D. (Deleng Morbiditas Fetal/Neonatal ing Ati-ati.)
Ora bisa digunakake ing wanita ngandhut kajaba, miturut pambiji saka dokter, penting kanggo kesejahteraan pasien lan keuntungan luwih gedhe tinimbang risiko. CDC lan tetrasiklin negara liyane bisa digunakake yen perlu kanggo perawatan antraks inhalasi ing wanita ngandhut. Amarga efek ala ing untu lan balung sing berkembang ana hubungane karo dosis, CDC nyaranake yen tetrasiklin bisa digunakake kanggo wektu sing cendhak (7-14 dina) sadurunge 6 sasi ngandhut; sawetara dokter nyaranake tes fungsi ati periodik yen digunakake ing wanita ngandhut.
LaktasiDistribusi menyang susu; mungkasi nyusoni utawa obat kasebut.
AAP nyatakake panggunaan tetrasiklin kanggo ibu biasane cocog karo nyusoni amarga panyerepan obat kasebut dening bayi sing nyusoni bisa diabaikan.
Panggunaan PediatrikOra bisa digunakake ing bocah-bocah <8 taun. umur kajaba keuntungan ngluwihi risiko. (Deleng Efek Gigi lan Balung ing Ngati-ati.)
Panggunaan GeriatrikPengalaman sing ora cukup ing umur ≥65 taun kanggo nemtokake manawa reaksi kasebut beda karo wong diwasa sing luwih enom.
Pilih dosis kanthi ati-ati amarga nyuda fungsi ati, ginjel, lan / utawa jantung sing gegandhengan karo umur lan penyakit bebarengan lan terapi obat; umume miwiti terapi kanthi nggunakake dosis sing paling sithik.
Gangguan HepatikGunakake kanthi ati-ati.
Gagal ginjalBisa nyebabake konsentrasi minocycline serum sing dhuwur lan azotemia, hiperfosfatemia, lan acidosis.
Akumulasi obat sing berlebihan lan kemungkinan keracunan ati bisa kedadeyan yen dosis biasa digunakake ing pasien sing duwe gangguan ginjel. Penyesuaian dosis perlu kanggo pasien sing duwe fungsi ginjel cacat. (Deleng Gagal Ginjal ing Dosis lan Administrasi.)
Monitor bun serum lan BUN.
Amarga dosis biasa doxycycline bisa digunakake ing pasien sing duwe fungsi ginjel cacat, bisa uga luwih disenengi nalika tetrasiklin dituduhake ing pasien kanthi fungsi ginjel cacat.
Efek Umum sing Sabar
Efek GI (anoreksia, mual, muntah, diare); efek CNS (pusing, vertigo); reaksi hipersensitivitas; BUN sing gegandhengan karo dosis mundhak.
Apa obatan liyane bakal mengaruhi Minocycline (Systemic)
Obat Spesifik
Obat
Interaksi
Komentar
Antacid (aluminium, kalsium, utawa magnesium)
Penurunan penyerapan minocycline
Administrasi antacid sing ngandhut aluminium, kalsium, utawa magnesium 1-2 jam sadurunge utawa sawise minocycline
Anticoagulants, oral
Mungkin nambah efek antikoagulan; tetrasiklin bisa ngrusak panggunaan prothrombin utawa nyuda produksi vitamin K dening bakteri usus
Monitor PT kanthi teliti; atur dosis antikoagulan sing dibutuhake
Alkaloid Ergot
Peningkatan risiko ergotisme
Kontrasepsi hormonal
Kemungkinan penurunan efektifitas kontrasepsi oral
Gunakake kontrasepsi nonhormonal alternatif
Kandhut wesi preparat
Kamungkinan nyuda penyerapan minocycline
Administrasi minocycline 2 jam sadurunge utawa 3 jam sawise persiapan wesi oral
Isotretinoin
Kamungkinan aditif efek sistem saraf sing ala; minocycline lan isotretinoin wis digandhengake karo pseudotumor cerebri
Aja nggunakake isotretinoin sakcepete sadurunge, sajrone, utawa sawise terapi minocycline
Methoxyflurane
Kemungkinan nefrotoksisitas fatal
Panganggone bebarengan ora dianjurake
Penisilin
Mungkin antagonisme
Koncomitant nggunakake ora dianjurake
Disclaimer
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