Mometasone
Kelas obat: Agen Antineoplastik
Panganggone Mometasone
Asma
Mometasone: Pangopènan perawatan asma minangka terapi profilaksis.
Mometasone ing kombinasi tetep karo formoterol (mometasone/formoterol): Perawatan asma ing pasien sing ora nanggapi kanthi cukup kanggo terapi pengontrol asma jangka panjang (contone, kortikosteroid inhalasi) utawa sing keruwetan penyakit mbutuhake wiwitan perawatan karo loro kasebut. kortikosteroid sing dihirup lan agonis β2-adrenergik sing dawa tumindak.
Mometasone piyambak utawa ing kombinasi tetep karo formoterol: Ora dituduhake kanggo perawatan bronkospasme akut (yaiku, minangka terapi penyelamat kanggo perawatan episode bronkospasme akut) .
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Carane nggunakake Mometasone
Umum
Konversi menyang Terapi Inhalasi Oral ing Pasien sing Nampa Kortikosteroid Sistemik
Administrasi
Inhalasi Oral
Mometasone (Asmanex Twisthaler): Atur dening inhalasi lisan minangka bubuk inhalasi lisan nggunakake piranti inhalasi bubuk garing Twisthaler breath-actuated.
Mometasone (Asmanex HFA): Diwenehake kanthi inhalasi lisan minangka suspensi inhalasi lisan nggunakake inhaler aerosol dosis meter kanthi propelan hidrofluoroalkana (HFA; non-chlorofluorocarbon).
Mometasone/formoterol fixed kombinasi (Dulera): Atur kanthi inhalasi lisan minangka suspensi inhalasi lisan nggunakake inhaler aerosol dosis meter kanthi propelan HFA.
Sabanjure saben dosis mometasone utawa mometasone/formoterol, mbilas tutuk kanthi banyu tanpa ngulu.
Bubuk Inhalasi OralAtur minangka inhalasi lisan siji utawa kaping pindho saben dina. Nalika diwènèhaké sapisan dina, gunakake ing wektu sing padha saben dina, luwih becik ing wayah sore kanggo efektifitas sing optimal.
Mbusak tutup saka piranti Twisthaler (kanthi putar arah arah jarum jam) ngeculake dosis siji obat. saka unit panyimpenan obat menyang saluran inhalasi, nggawe dosis kasedhiya kanggo administrasi liwat inhalasi lisan liwat mouthpiece. Penghitung dosis bakal suda 1 saben tutup dicopot. Copot tutup Twisthaler kanthi inhaler ing posisi tegak. Sadurunge inhalasi dosis, exhale sakbisane, nanging ora menyang piranti Twisthaler. Selehake cangkeme inhaler ing antarane lambe lan ambegan kanthi cepet lan jero liwat inhaler. Aja nutupi bolongan ventilasi ing salah siji sisih inhaler nalika inhalasi dosis. Copot inhaler saka tutuk, tahan ambegan watara 10 detik, banjur ambegan alon-alon.
Ngusap tutuk nganti garing nganggo kain utawa tisu garing. Nutup lan muat maneh piranti Twisthaler kanggo dosis sabanjure kanthi nggulung tutup ing arah jarum jam nganti ana klik. Aja wisuh inhaler; simpen ing panggonan kang garing. Buang inhaler nalika saben inhalasi digunakake (nalika indikator dosis maca "00") utawa 45 dina sawise dicopot saka kantong overwrap foil, endi wae sing luwih dhisik.
Oral Inhalation AerosolAdministrasi minangka 2 inhalasi lisan kaping pindho dina (esuk lan sore).
Gunakake mung karo aktuator sing disedhiyakake karo produk.
Mometasone (Asmanex HFA): Tes semprotan 4 kaping menyang udhara (adoh saka pasuryan) sadurunge pisanan nggunakake utawa yen ora digunakake kanggo> 5 dina; goyangake sadurunge saben semprotan tes lan saben inhalasi. Copot tutup saka mouthpiece saka aktuator sadurunge digunakake. Aja wisuh inhaler ing banyu; ngresiki cangkeme nganggo lap garing saben 7 dina.
Mometasone/formoterol kombinasi tetep (Dulera): Tes semprotan 4 kaping menyang udhara (adoh saka pasuryan) sadurunge digunakake pisanan utawa yen ora digunakake kanggo >5 dina; goyangake sadurunge saben semprotan tes lan saben inhalasi. Resik inhaler saben 7 dina kanthi ngusap cangkem nganggo kain garing; aja wisuh inhaler ing banyu.
Dosis
Kasedhiya minangka mometasone furoate; dosis ditulis ing syarat-syarat uyah.
Uga kasedhiya minangka kombinasi tetep sing ngandhut mometasone furoate lan formoterol fumarate dihydrate (mometasone/formoterol); dosis komponen mometasone sing dituduhake ing syarat-syarat uyah lan dosis komponen formoterol sing ditulis ing syarat-syarat uyah terhidrasi.
Kekuwatan lan dosis mometasone furoate sing diwenehake minangka bubuk inhalasi lisan (Asmanex Twisthaler) dituduhake minangka dosis nominal (label) sing ana ing piranti Twisthaler. Jumlah obat sing dikirim menyang paru-paru gumantung saka sawetara faktor, kayata aliran inspirasi pasien. Saben aktuasi piranti Twisthaler ngemot 110 utawa 220 mcg bubuk inhalasi oral mometasone furoate lan ngirim kira-kira 100 utawa 200 mcg mometasone furoate saka corong, gumantung saka persiapan sing digunakake.
Saben aktuasi inhaler aerosol oral ngemot mometasone furoate (Asmanex HFA) ngirimake 115 utawa 225 mcg mometasone furoate saka katup lan 100 utawa 200 mcg mometasone furoate saka aktuator, gumantung saka persiapan sing digunakake. Kekuwatan lan dosis saka preparat ditulis ing syarat-syarat tamba dikirim saka mouthpiece saka actuator. Jumlah nyata obat sing dikirim menyang paru-paru gumantung saka sawetara faktor, kayata koordinasi antarane aktuasi piranti lan aliran inspirasi pasien. Inhaler aerosol Asmanex HFA ngirimake 120 aktuasi saben tabung 13-g.
Saben aktuasi inhaler aerosol oral sing ngemot kombinasi tetep mometasone/formoterol (Dulera) ngasilake 115 utawa 225 mcg mometasone furoate lan 5,5 mcg saka formoterol. fumarate dihydrate saka katup lan ngirim 100 utawa 200 mcg mometasone furoate lan 5 mcg formoterol fumarate dihydrate saka aktuator, gumantung saka persiapan sing digunakake. Kekuwatan lan dosis saka preparat ditulis ing syarat-syarat tamba dikirim saka mouthpiece saka actuator. Jumlah nyata obat sing dikirim menyang paru-paru gumantung saka sawetara faktor, kayata koordinasi antarane aktuasi piranti lan aliran inspirasi pasien. Dulera aerosol inhaler ngirim 60 utawa 120 meter semprotan saben 8.8- utawa 13-g canister, mungguh.
Pasien Anak
Asma Mometasone Oral Inhalation PowderBocah 4-11 taun: Awal lan dosis maksimal yaiku 110 mcg sapisan dina ing wayah sore, preduli saka terapi sadurunge.
Remaja ≥12 taun sadurunge nampa bronkodilator piyambak utawa kortikosteroid inhalasi: Kaping pisanan, 220 mcg sapisan dina ing wayah sore. Yen kontrol asma ora cukup sawise 2 minggu terapi ing dosis awal, dosis sing luwih dhuwur bisa nyedhiyakake kontrol asma tambahan. Yen perlu, dosis bisa ditambah nganti maksimal 440 mcg saben dina (440 mcg sapisan dina utawa 220 mcg kaping pindho saben dina).
Remaja ≥12 taun sadurunge nampa kortikosteroid oral: Dosis awal lan maksimum yaiku 440 mcg kaping pindho saben dina.
Aerosol Inhalasi OralRemaja ≥12 taun sadurunge nampa kortikosteroid dosis menengah sing dihirup: 200 mcg (2 inhalasi persiapan sing ngemot 100 mcg) kaping pindho saben dina.
Remaja ≥ Umur 12 taun sadurunge nampa kortikosteroid dosis dhuwur utawa kortikosteroid oral sing dihirup: 400 mcg (2 inhalasi persiapan sing ngemot 200 mcg) kaping pindho saben dina.
Yen kontrol asma ora cukup sawise 2 minggu kanthi dosis sing luwih murah, coba ganti. kanggo persiapan kekuatan sing luwih dhuwur, miwiti terapi karo kortikosteroid oral, utawa miwiti terapi inhalasi oral kanthi kombinasi tetep sing ngemot kortikosteroid lan agonis β2 tumindak dawa.
Mometasone/Formoterol Kombinasi Tetap Oral Inhalasi AerosolRemaja ≥12 taun: 200 utawa 400 mcg mometasone furoate lan 10 mcg formoterol fumarate dihydrate (2 inhalasi persiapan sing ngemot 100 utawa 200 mcg mometasone furoate / 5 mcg formoterol fumarate dihydrate) kaping pindho saben dina. Pilih dosis awal adhedhasar keruwetan asma, terapi asma sadurunge (kalebu dosis kortikosteroid sing dihirup sadurunge), kontrol gejala asma saiki, lan risiko eksaserbasi asma ing mangsa ngarep.
Yen kontrol asma ora nyukupi sawise 2 minggu ing dosis sing luwih murah, ngalih menyang persiapan sing luwih kuat saka kombinasi tetep (kekuwatan sing luwih dhuwur mung ngemot dosis mometasone sing luwih dhuwur) bisa nyedhiyakake kontrol asma tambahan.
Wong diwasa h4> Asma Mometasone Oral Inhalation Powder
Sadurungé nampa bronkodilator piyambak utawa inhalasi kortikosteroid: Kaping pisanan, 220 mcg sapisan dina ing wayah sore. Yen kontrol asma ora cukup sawise 2 minggu terapi ing dosis awal, dosis sing luwih dhuwur bisa nyedhiyakake kontrol asma tambahan. Yen perlu, dosis bisa ditambah nganti maksimal 440 mcg saben dina (440 mcg sapisan dina utawa 220 mcg kaping pindho saben dina).
Sadurungé nampa kortikosteroid oral: Dosis awal lan maksimum yaiku 440 mcg kaping pindho saben dina.
p> Aerosol Inhalasi OralSadurungé nampa kortikosteroid dosis menengah sing dihirup: 200 mcg (2 inhalasi preparat sing ngandhut 100 mcg) kaping pindho saben dina.
Sadurungé nampa kortikosteroid dosis dhuwur utawa kortikosteroid oral sing dihirup: 4000 mcg. (2 inhalasi persiapan sing ngemot 200 mcg) kaping pindho saben dina.
Yen kontrol asma ora cukup sawise 2 minggu terapi kanthi dosis sing luwih murah, coba ganti menyang persiapan sing luwih kuat, miwiti terapi karo kortikosteroid oral, utawa miwiti terapi inhalasi oral kanthi kombinasi tetep sing ngandhut kortikosteroid lan agonis β2 tumindak dawa.
Mometasone/Formoterol Kombinasi Tetap Oral Inhalasi Aerosol200 utawa 400 mcg mometasone furoate lan 10 mcg formoterol fumarate dihydrate (2 inhalasi persiapan sing ngemot 100 utawa 200 mcg mometasone furoate / 5 mcg formoterol fumarate dihydrate) kaping pindho saben dina. Pilih dosis awal adhedhasar keruwetan asma, terapi asma sadurunge (kalebu dosis kortikosteroid sing dihirup sadurunge), kontrol gejala asma saiki, lan risiko eksaserbasi ing mangsa ngarep.
Yen kontrol asma ora cukup sawise 2 minggu terapi ing ngisor. dosis, ngalih menyang persiapan sing luwih dhuwur saka kombinasi tetep (kekuwatan sing luwih dhuwur mung ngemot dosis mometasone sing luwih dhuwur) bisa nyedhiyakake kontrol asma tambahan.
Watesan Resep
Pasien Pediatrik
Asma Mometasone Oral Inhalation PowderBocah 4–11 taun: Maksimum 110 mcg saben dina.
Remaja ≥12 taun sadurunge nampa bronkodilator piyambak utawa kortikosteroid inhalasi: Maksimum 440 mcg saben dina.
Remaja ≥12 taun sadurunge nampa kortikosteroid oral: Maksimum 880 mcg saben dina.
Oral Inhalasi AerosolRemaja ≥12 taun: Maksimum 800 mcg saben dina.
Mometasone/Formoterol Fixed Combination Aerosol Inhalasi OralRemaja ≥12 taun: Maksimum 800 mcg mometasone furoate lan 20 mcg formoterol fumarate dihydrate saben dina.
Dewasa
Asma Mometasone Oral Inhalation PowderSaderengipun dipunsebat bronkodilator tunggal utawa kortikosteroid inhalasi: Maksimum 440 mcg saben dina.
Sadurungé nampa kortikosteroid oral: Maksimum 880 mcg saben dina.
Aerosol Inhalasi OralMaksimum 800 mcg saben dina.
Mometasone/Formoterol Aerosol Inhalasi Oral Kombinasi TetapMaksimum 800 mcg mometasone furoate lan 20 mcg formoterol fumarate dihydrate saben dina.
Populasi Khusus
Gangguan Hepatik
Pantau pasien kanggo pratandha saka tambah tamba tamba.
Gagal ginjal
Ora ana rekomendasi dosis khusus ing wektu iki.
Pènget
Kontraindikasi
Pènget/PanandhapPanganggone Kombinasi Tetep
Nalika mometasone digunakake ing kombinasi tetep karo formoterol, nimbang ati-ati, pancegahan, kontraindikasi, lan interaksi sing ana gandhengane karo formoterol. (Deleng Resiko Kedadeyan Asma Serius ing Waspada.)
Eksaserbasi Akut Asma
Aja nggunakake mometasone piyambak utawa ing kombinasi tetep karo formoterol minangka bronkodilator; ora dituduhake kanggo panggunaan darurat (contone, status asthmaticus) utawa nyuda bronkospasme akut. Nambani gejala asma akut kanthi bronkodilator β2-agonis short-acting. Yen kontrol gejala sing ora nyukupi tetep karo terapi bronkodilator β2-agonist tambahan, evaluasi maneh terapi asma kanthi cepet. Evaluasi ulang kasebut bisa uga kalebu penyesuaian dosis kortikosteroid sing dihirup utawa wiwitan kortikosteroid sistemik.
Infeksi Candida Lokal
Infeksi candidal ing tutuk lan pharynx kacarita. Yen infèksi kasebut kedadeyan, miwiti perawatan antijamur lokal utawa sistemik sing cocog nalika isih nerusake terapi mometasone sing dihirup. Bisa uga mbutuhake gangguan terapi mometasone ing sawetara pasien. Cuci tutuk nganggo banyu (tanpa ngulu) sawise inhalasi lisan kanggo nyuda risiko kandidiasis oropharyngeal.
Pasien Imunosupresan.
Tambah kerentanan kanggo infeksi ing pasien sing njupuk obat imunosupresan dibandhingake karo wong sing sehat. Infèksi tartamtu (contone, cacar air, campak) bisa nyebabake asil sing luwih serius utawa malah fatal ing pasien kasebut, utamane ing bocah-bocah.
Ngati-ati supaya ora kena paparan ing pasien sing rentan. Yen paparan cacar air utawa campak dumadi ing pasien sing rentan, pertimbangake kanggo menehi varicella zoster immune globulin (VZIG) utawa, immune globulin IM (IGIM), mungguh. Coba perawatan karo agen antivirus yen cacar ayam berkembang.
Gunakake kanthi ati-ati, yen kabeh, ing pasien kanthi infeksi Mycobacterium tuberculosis klinis utawa tanpa gejala ing saluran pernapasan; infèksi jamur, bakteri, parasit utawa virus sing ora diobati; utawa herpes simpleks okular.
Penundaan Kortikosteroid Sistemik
Kamungkinan insufisiensi adrenal sing ngancam nyawa ing pasien sing diowahi saka kortikosteroid sistemik menyang kortikosteroid sing dihirup oral, kalebu mometasone.
Mbusak terapi kortikosteroid sistemik kanthi bertahap lan ngawasi pratandha obyektif saka insufficiency adrenal (contone, lemes, lemes, kekirangan, mual, muntah, hipotensi) nalika mundur saka terapi sistemik. Ngawasi fungsi paru-paru kanthi ati-ati (FEV1 utawa tingkat aliran ekspirasi puncak [PEFR]), panggunaan agonis adrenergik β2 tambahan, lan gejala asma. Ing umume pasien, sawetara wulan dibutuhake kanggo pulih total fungsi hypothalamic-pituitary adrenal (HPA) sawise mundur saka terapi kortikosteroid sistemik. Pasien sing njaga ≥20 mg prednison (utawa sing padha) saben dina bisa uga paling rentan kanggo kedadeyan sing ora dikarepake, utamane ing bagian pungkasan saka transfer.
Pantau pasien kanggo gejala penarikan kortikosteroid (umpamane, nyeri sendi, nyeri otot, lesu, depresi).
Pantau pasien kanggo insufisiensi adrenal akut sajrone paparan trauma, operasi, utawa infeksi (utamane gastroenteritis) utawa kahanan liyane sing ana gandhengane karo mundhut elektrolit akut.
Kamungkinan mbukak tutup saka kondisi sing sadurunge dikontrol dening terapi kortikosteroid sistemik (contone, rhinitis, konjungtivitis, eksim, arthritis, kondisi eosinofilik).
Efek Kortikosteroid Sistemik
Sanajan mung panyerepan sistemik minimal sing kedadeyan sawise inhalasi oral, administrasi mometasone sing dihirup kanthi dosis sing luwih dhuwur tinimbang sing disaranake sajrone wektu sing suwe utawa ing wong sing sensitif bisa nyebabake manifestasi hiperkortisisme lan nyuda fungsi HPA. Yen owah-owahan kasebut kedadeyan, nyuda dosis mometasone alon-alon, konsisten karo prosedur sing ditampa kanggo nyuda dosis kortikosteroid sistemik lan ngatur gejala asma.
Ngati-ati khusus kanggo ngawasi pasien sawise operasi utawa sajrone stres kanggo bukti respon adrenal sing ora cukup.
Efek Muskuloskeletal
Panganggone jangka panjang bisa nyebabake metabolisme balung normal, sing nyebabake ilang kepadatan mineral balung (BMD).
Pantau pasien kanthi faktor risiko utama kanggo nyuda BMD (umpamane, riwayat kulawarga osteoporosis, imobilisasi sing suwe, panggunaan obat-obatan kronis sing bisa nyuda massa balung [contone, antikonvulsan, kortikosteroid]) lan ngobati kanthi standar sing wis ditemtokake. ngrawat.
Efek Ophthalmic
Penggunaan jangka panjang bisa nyebabake glaukoma, peningkatan TIO, lan katarak. Coba rujukan menyang ophthalmologist ing pasien sing ngalami gejala ophthalmic utawa sing nampa terapi jangka panjang karo mometasone.
Bronkospasme
Kamungkinan bronkospasme paradoks akut sing ngancam nyawa bisa kedadeyan kanthi nambah wheezing. Yen ana bronkospasme paradoks, langsung nambani pasien kanthi bronkodilator sing dihirup, short-acting lan mungkasi mometasone.
Reaksi Sensitivitas
Reaksi hipersensitivitas langsung (contone, anafilaksis, ruam, pruritus, angioedema, urtikaria, kemerahan, dermatitis alergi, bronkospasme). Mungkasi mometasone yen reaksi kasebut kedadeyan.
Wudak inhalasi lisan ngemot laktosa cilik kanthi jumlah protein susu sing sithik. Reaksi anafilaksis ing pasien karo alergi protein susu dilaporake; Aja nggunakake ing patients karo dikenal alergi protein susu. (Deleng Contraindications ing Cautions.)
Risiko Kedadeyan sing Gegandhengan karo Asma Serius
Monoterapi karo agonis β2-adrenergik long-acting, kayata formoterol, komponen mometasone/formoterol, nambah risiko pati sing gegandhengan karo asma. Data saka uji klinis nuduhake yen monoterapi karo agonis β2-adrenergik sing tumindak dawa uga nambah risiko rawat inap sing gegandhengan karo asma ing bocah lan remaja.
Adhedhasar review saka 4 uji klinis (3 ing wong diwasa lan remaja lan 1 ing bocah-bocah), FDA nyimpulake ora ana risiko tambah klinis sing penting kanggo kedadeyan sing gegandhengan karo asma sing serius (yaiku, rawat inap sing gegandhengan karo asma, intubasi, pati) sing ana gandhengane karo panggunaan kombinasi tetep sing ngemot agonis β2-adrenergik long-acting lan kortikosteroid sing dihirup dibandhingake. karo kortikosteroid inhalasi mung kanggo perawatan asma. Panaliten kasebut uga nuduhake yen terapi kombinasi karo agonis β2-adrenergik sing tumindak dawa lan kortikosteroid sing dihirup nyuda kedadeyan eksaserbasi asma dibandhingake karo nggunakake kortikosteroid sing dihirup wae.
Gunakake kombinasi tetep mometasone/formoterol mung ing pasien asma sing ora nanggapi kanthi cukup kanggo terapi pengontrol asma jangka panjang, (umpamane, kortikosteroid inhalasi) utawa sing keruwetan penyakit mbutuhake wiwitan perawatan karo kortikosteroid inhalasi lan a agonis β2-adrenergik long-acting.
Populasi Tertentu
KandhutanKategori C.
Ora ana studi sing nyukupi lan dikontrol kanthi apik ing wanita ngandhut. Gunakake nalika meteng mung yen keuntungan potensial mbenerake potensial risiko kanggo janin.
Tambah risiko asil perinatal sing ora becik (contone, preeclampsia, lair prematur, bobot lair kurang, bayi cilik kanggo umur gestational) ing wanita kanthi kurang utawa moderat. asma sing dikontrol. Ngawasi wanita ngandhut kanthi asma lan atur obat yen perlu kanggo njaga kontrol asma sing optimal.
Efek kombinasi tetep mometasone/formoterol nalika nglairake lan nglairake ora dingerteni. Amarga ana potensial interferensi β-agonist karo kontraktilitas uterus, mbatesi panggunaan mometasone/formoterol sajrone meteng kanggo pasien sing entuk manfaat luwih gedhe tinimbang risiko. meteng kanggo pratandha hypoadrenalism.
LaktasiOra dingerteni manawa mometasone disebarake menyang susu; Nanging, kortikosteroid liyane disebarake menyang susu. Data ora kasedhiya babagan efek obat kasebut ing bayi sing disusui utawa produksi susu. Coba manfaat saka nyusoni lan pentinge mometasone kanggo wong wadon bebarengan karo potensial efek salabetipun ing bayi-disusun saka tamba utawa kondisi ibu ndasari. Disaranake ati-ati yen bubuk inhalasi lisan mometasone digunakake ing wanita sing nyusoni.
Produsen kombinasi tetep mometasone/formoterol nyatakake yen keputusan kudu ditindakake apa arep mandheg nyusoni utawa obat kasebut, kanthi nggatekake pentinge obat kasebut. Wong wadon.
Gunakake PediatrikMometasone bubuk inhalasi lisan: Keamanan lan khasiat ora ditetepake ing bocah-bocah <4 taun.
Mometasone oral inhalation aerosol: Safety lan khasiat ora ditetepake ing bocah-bocah < 12 taun.
Mometasone/formoterol oral inhalasi aerosol: Safety lan khasiat ora ditetepake ing bocah <12 taun.
Kanthi panggunaan sing dawa, bisa nyuda tingkat pertumbuhan ing bocah lan remaja. Ngawasi kanthi rutin (umpamane, liwat stadiometri) wutah lan perkembangan pasien pediatrik sing nampa terapi kortikosteroid. Timbang keuntungan saka terapi kortikosteroid versus kemungkinan dipatèni wutah lan risiko sing ana gandhengane karo terapi alternatif. Gunakake dosis paling murah sing efektif ngontrol asma.
Panggunaan GeriatrikOra ana bedane signifikan ing safety lan khasiat relatif kanggo wong diwasa enom, nanging tambah sensitivitas ora bisa ditolak lewat.
Efek Umum sing Sabar
Aerosol inhalasi oral Mometasone: Nasofaringitis, sirah, sinusitis, bronkitis, influenza.
Wudak inhalasi oral mometasone: Sakit sirah, rhinitis alergi, faringitis, ndhuwur infeksi saluran pernapasan, sinusitis, kandidiasis oral, dysmenorrhea, nyeri muskuloskeletal, nyeri punggung, dyspepsia.
Mometasone/formoterol oral inhalasi aerosol: Nasofaringitis, sinusitis, sirah.
Apa obatan liyane bakal mengaruhi Mometasone
Informasi ing ngisor iki alamat potensial interaksi karo mometasone. Ora ana studi interaksi obat resmi sing ditindakake nganti saiki nggunakake mometasone / formoterol. Nalika kombinasi tetep digunakake, uga nimbang interaksi sing ana gandhengane karo formoterol.
Mometasone dimetabolisme dening isoenzim CYP3A4.
Obat sing Ngaruhi Enzim Mikrosomal Hepatik
Inhibitor kuat CYP3A4: Potensi interaksi farmakokinetik (tambah konsentrasi mometasone plasma).
Obat Spesifik
Obat
Interaksi
Komentar
Anti jamur, azoles (itrakonazol, ketokonazol)
p>Konsentrasi mometasone tambah lan potensial efek kortikosteroid sistemik sing ala
Gunakake kanthi ati-ati; yen perlu nggunakake bebarengan, monitor efek kortikosteroid sistemik sing ora becik
Antiretroviral, inhibitor protease HIV (atazanavir, indinavir, nelfinavir, ritonavir, saquinavir)
Peningkatan konsentrasi mometason lan potensial kanggo efek kortikosteroid sistemik sing saleh
Gunakake kanthi ati-ati; yen perlu nggunakake bebarengan, monitor efek kortikosteroid sistemik sing saleh
Persediaan sing ngemot kobicistat
Peningkatan konsentrasi mometasone lan potensial kanggo efek kortikosteroid sistemik sing saleh
Gunakake kanthi ati-ati ; yen perlu, pantau efek kortikosteroid sistemik sing saleh
Macrolides (clarithromycin)
Peningkatan konsentrasi mometasone lan potensial efek kortikosteroid sistemik sing saleh
Gunakake kanthi ati-ati ; yen perlu nggunakake bebarengan, monitor efek kortikosteroid sistemik sing saleh
Nefazodone
Peningkatan konsentrasi mometasone lan potensial kanggo efek kortikosteroid sistemik sing saleh
Gunakake kanthi ati-ati; yen perlu nggunakake bebarengan, monitor kanggo efek kortikosteroid sistemik salabetipun
Disclaimer
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