Respiratory Syncytial Virus Vaccine, Adjuvanted (Systemic)
Kelas obat: Agen Antineoplastik
Panganggone Respiratory Syncytial Virus Vaccine, Adjuvanted (Systemic)
Nyegah Penyakit Saluran Pernafasan Ngisor Disebabake RSV
Vaksin RSV, adjuvant digunakake kanggo imunisasi aktif kanggo nyegah penyakit saluran pernapasan ngisor (LRTD) sing disebabake dening RSV ing wong sing umure ≥60 taun.
Vaksinasi kanthi dosis siji vaksin RSV wis nuduhake efektifitas moderat nganti dhuwur kanggo nyegah LRTD sing gegandhengan karo gejala RSV ing kelompok umur iki.
Komite Penasihat Pusat Pengendalian lan Pencegahan Penyakit (CDC) AS babagan Praktek Imunisasi (ACIP) nyaranake supaya wong diwasa ≥60 taun bisa nampa vaksin RSV siji dosis, nggunakake pengambilan keputusan klinis bebarengan. Vaksinasi ing wong diwasa kudu ditargetake kanggo wong-wong sing duwe risiko paling dhuwur kanggo penyakit RSV sing abot lan mulane bakal entuk manfaat.
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Carane nggunakake Respiratory Syncytial Virus Vaccine, Adjuvanted (Systemic)
Umum
Dispensing lan Pancegahan Administrasi
Administrasi
Administrasi IM
Administrasi mung kanthi injeksi IM .
Diwenehake ing otot deltoid.
Disedhiyakake minangka vial dosis siji saka komponen antigen lyophilized kanggo digabungake maneh karo vial komponen suspensi adjuvant.
Reconstitute komponèn antigen lyophilized (wêdakakêna putih steril) karo komponen suspensi adjuvant (opalescent, Cairan steril ora ana werna kanggo coklat pucet).
Mung gunakake komponen suspensi adjuvant sing diwenehake kanggo rekonstitusi.
Nganggo teknik aseptik, copot kabeh komponen suspensi adjuvan (cairan) kanthi jarum lan jarum suntik steril.
Alon-alon transfer kabeh isi jarum suntik menyang vial komponen antigen sing wis diliofil. Alon-alon swirl vial nganti bubuk rampung larut; aja goyangake kanthi kuat.
Vaksin sing dikonstitusi kudu dadi cairan opalescent, ora ana warna nganti coklat pucet; aja gunakake yen warnane pucet utawa ngandhut partikel.
Anakake vaksin sanalika sawise rekonstitusi, utawa simpen ing antarane 2°-25°C sing dilindhungi saka cahya, lan gunakake sajrone 4 jam. Buang vaksin sing wis direkonstitusi yen ora digunakake sajrone 4 jam.
Kanggo menehi dosis, copot 0,5 ml vaksin sing wis direkonstitusi lan injeksi IM.
Dosis
Wong diwasa
Nyegah Penyakit Saluran Pernafasan Ngisor Disebabake dening RSV IMKanggo imunisasi aktif kanggo nyegah penyakit saluran napas ngisor sing disebabake dening RSV ing pasien ≥60 taun: ngatur dosis tunggal 0,5-mL.
Pènget
Kontraindikasi
Pènget/PanandhapNyegah lan Ngatur Reaksi Vaksin Alergi
Pengobatan lan pengawasan medis sing cocog kudu kasedhiya kanggo ngatur kemungkinan reaksi anafilaksis.
Syncope
Syncope (pingsan) bisa kedadeyan. Priksa manawa prosedur wis ditindakake supaya ora cilaka amarga semaput.
Individu kanthi Imunokompetensi sing Diowahi
Pikirake kemungkinan respon imun kanggo vaksin bisa suda utawa ora optimal ing individu kasebut.
Populasi Tertentu
KandhutanOra disetujoni kanggo digunakake ing individu <60 taun.
Tambah lair prematur sing diamati ing wong ngandhut sing nampa vaksin antigen RSVPreF3 sing ora diselidiki. p> Laktasi
Ora disetujoni kanggo digunakake ing individu <60 taun. Ora dingerteni manawa vaksin IRSV respiratory syncytial virus, adjuvant disebarake ing susu manungsa. Ora ana data sing kasedhiya kanggo ngevaluasi efek ing bayi sing disusui utawa ing produksi susu.
Pirsani keuntungan pangembangan lan kesehatan saka nyusoni bebarengan karo kabutuhan klinis ibu kanggo vaksinasi lan efek negatif sing potensial kanggo bocah sing disusui saka vaksin utawa kondisi ibu sing ndasari (kerentanan kanggo penyakit sing dicegah dening vaksin).
Panggunaan PediatrikOra disetujoni kanggo digunakake ing wong sing umure <60 taun. Bukti saka model kewan banget nyaranake administrasi ora aman kanggo bocah-bocah <2 taun amarga risiko tambah penyakit pernapasan. Keamanan lan khasiat ora ditetepake ing bocah-bocah umur 2-17 taun.
Panggunaan GeriatrikDisetujoni kanggo digunakake ing wong sing umure ≥60 taun. Kabeh individu sing didaftarake ing studi khasiat utama yaiku umure ≥60 taun.
Efek Samsaya Awon
Reaksi salabetipun lokal umum (≥10%): nyeri situs injeksi.
Reaksi salabetipun sistemik umum (≥10%): lemes, mialgia, sirah, artralgia.
Apa obatan liyane bakal mengaruhi Respiratory Syncytial Virus Vaccine, Adjuvanted (Systemic)
Obat Spesifik
Obat
Interaksi
Komentar
Vaksin influenza
Vaksin influenza kuadrivalen parenteral sing ora aktif: Ora ana bukti interferensi ing respon imun nalika diwenehake bebarengan utawa dipisahake sajrone 1 sasi
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