Selenious Acid
Kelas obat: Agen Antineoplastik
Panganggone Selenious Acid
Selenium nduweni kegunaan ing ngisor iki:
Injeksi selenium dituduhake kanggo digunakake minangka tambahan kanggo solusi intravena sing diwenehake kanggo nutrisi parenteral total (TPN). Administrasi selenium ing solusi TPN mbantu njaga tingkat selenium plasma lan nyegah penipisan toko endogen lan gejala kekurangan sabanjure.
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Carane nggunakake Selenious Acid
Umum
Selenium kasedhiya ing wangun dosis lan kekuatan:
Injeksi selenium sing ngandhut asam selenious 65,4 mcg/mL (padha karo unsur selenium 40 mcg/mL).
Dosis
Injeksi selenium nyedhiyakake 40 mcg selenium / mL. Kanggo wong diwasa kanthi metabolisme stabil sing nampa TPN, tingkat dosis aditif sing disaranake yaiku 20 nganti 40 mcg selenium / dina. Kanggo pasien pediatrik, tingkat dosis aditif sing disaranake yaiku 3 mcg / kg / dina.
Ing wong diwasa kanthi kekurangan selenium amarga dhukungan TPN jangka panjang, selenium minangka selenomethionine utawa asam selenious, diterbitake intravena kanthi 100 mcg. / dina kanggo periode 24 lan 31 dina, mungguh, wis dilapurake kanggo mbalikke gejala kurang tanpa keracunan.
Tambahan aseptik injeksi selenium kanggo solusi TPN ing hood aliran laminar dianjurake. Selenium kompatibel kanthi fisik karo elektrolit lan unsur trace liyane sing biasane ana ing larutan asam amino / dekstrosa sing digunakake kanggo TPN. Ngawasi tingkat selenium plasma sing kerep disaranake minangka pedoman kanggo administrasi sabanjure. Kisaran getih normal kanggo selenium kira-kira 10 nganti 37 mcg / 100 mL.
Aja langsung nyampur injeksi asam askorbat karo selenium sing ngemot produk parenteral ing jarum suntik utawa vial sing padha, amarga admixture iki bisa nyebabake pembentukan. saka endapan sing ora larut.
Produk obat parenteral kudu dipriksa kanthi visual babagan partikel lan warnane yen solusi lan wadhah ngidini.
Pènget
Kontraindikasi
Injeksi selenium ngirim ora diwenehi undiluted kanthi injeksi langsung menyang vena perifer amarga ana potensial kanggo phlebitis infus.
Pènget/PanandhapPènget
Keracunan Selenium
Injeksi selenium bisa dadi beracun yen diwenehake kanthi jumlah sing berlebihan. Suplemen solusi TPN karo selenium kudu langsung dihentikan yen gejala keracunan diamati. Kerep netepake tingkat selenium plasma sajrone dhukungan TPN lan pengawasan medis sing cedhak dianjurake.
HipotonisitasInjeksi selenium minangka solusi hipotonik lan kudu ditrapake mung ing campuran.
Toksisitas AluminiumProduk iki ngandhut aluminium sing bisa beracun. Aluminium bisa tekan tingkat beracun kanthi administrasi parenteral sing dawa yen fungsi ginjel cacat. Neonatus prematur utamane beresiko amarga ginjel durung diwasa, lan mbutuhake solusi kalsium lan fosfat sing akeh, sing ngemot aluminium.
Riset nuduhake yen pasien sing duwe fungsi ginjel cacat, kalebu neonatus prematur, sing nampa parenteral. aluminium kanthi jumlah luwih saka 4 nganti 5 mcg / kg / dina nglumpukake aluminium ing tingkat sing ana gandhengane karo sistem saraf pusat lan keracunan balung. Muatan jaringan bisa uga ana ing tingkat administrasi sing luwih murah.
Pancegahan Umum
Amarga selenium diilangi ing urin lan feces, suplemen selenium bisa diatur, dikurangi, utawa diilangi ing disfungsi ginjel lan/utawa gangguan gastrointestinal. Ing pasien sing nampa transfusi getih, kontribusi saka transfusi kasebut uga kudu dianggep. Penentuan tingkat plasma selenium sing kerep disaranake minangka pedoman.
Ing kewan, selenium kacarita bisa ningkatake aksi vitamin E lan ngurangi keracunan merkuri, kadmium, lan arsenik.
KandhutanKategori meteng C. Selenium ing tingkat dosis dhuwur (15-30 mcg / endhog) wis dilapurake duwe efek embriologis sing ora becik ing antarane pitik. Nanging, ora ana studi sing nyukupi lan dikontrol kanthi apik ing wanita ngandhut. Injeksi selenium kudu digunakake nalika meteng mung yen manfaat potensial mbenerake potensial resiko kanggo janin.
Anane selenium ing plasenta lan getih umbilical cord wis dilaporake ing manungsa.
Efek Umum sing Sabar
Jumlah selenium sing ana ing injeksi selenium cilik. Gejala keracunan saka selenium ora mungkin kedadeyan ing tingkat dosis sing disaranake.
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