Obat Codcerin-D umur dawa nambani gejala batuk garing, batuk karo dahak, batuk alergi (2 blister x 10 tablet)

Bentuk sediaan Kothak 2 blister x 10 tablet
Spesifikasi Kodein Fosfat, Guaifenesin
Komposisi Truong Tho Pharmaceutical Joint Stock Company

Komposisi

Thành phần cho 1 viên

Informasi komposisi	Isi
Kodein fosfat	10 mg
Guiifenesin	100 mg

Migunakake

indikasi

Obat codcerin-d dituduhake ing kasus ing ngisor iki:

dituduhake kanggo pasien sing umure luwih saka 12 taun kanggo nambani gejala batuk garing utawa iritasi, sputum lan ventilasi ambegan ing selesma utawa infeksi saluran napas ndhuwur.

kodein fosfat:

Kodein minangka turunan saka phenanthren, sing jenenge methylmorphin, gugus metil ngganti posisi hidrogen ing gugus hidroksil sing disambung karo nukleus aromatik ing molekul morfin, mula kodeine nduweni efek farmakologis sing padha karo morfin, yaiku analgesik lan nyuda batuk. Dibandhingake karo Morphin, Codeine luwih diserap ing bentuk lisan, nyebabake konstipasi kurang lan spasme bilier kurang. Ing dosis perawatan, inhibitor ambegan kurang (60% luwih murah tinimbang morfin) lan kurang gawe ketagihan tinimbang morfin lan nyuda rasa nyeri luwih sithik tinimbang morfin.

Kodein lan uyah bisa nyuda batuk amarga efek langsung ing pusat batuk ing otak; Codeine ngeringake sekresi ing saluran pernapasan lan nambah sekresi sekresi bronkus. Codeine ora cukup kanggo nyuda batuk. Codeine minangka nyuda batuk ing kasus batuk garing, sing nyebabake insomnia.

GuaiFenesin:

Guaifenesin duweni efek sputum kanthi ngganggu mukosa lambung, banjur ngrangsang sekresi ing saluran pernapasan, nambah volume Akibaté, obat kasebut nambah refleks batuk lan nggampangake ngusir dahak. Mekanisme iki beda karo mekanisme obat batuk, obat ora ilang batuk. Obat kasebut dituduhake kanggo nambani gejala batuk kanthi sputum sing kandel, angel diidoni amarga selesma, saluran pernapasan ndhuwur sing entheng. Obat kasebut asring digabungake karo bronkodilator, kemacetan irung, obat antihistamin utawa anti-watuk.

Farmakokinetik dinamis

kodein fosfat:

Kodein lan uyahe diserap kanthi apik liwat saluran pencernaan. Sawise ngombe, konsentrasi puncak Codein Phosphate ing getih tekan sawise 1 jam. Kodein dimetabolisme ing ati kanthi nyuda metil (ing posisi O-lan N-metil ing molekul) dadi morfin, norcodeine lan metabolit liyane kayata Normorphin lan Hydrocodon. Transformasi dadi morfin ora langsung dipengaruhi dening Cytochrom P450 Isoenzyme CYP2D6 lan efek iki beda banget amarga efek saka struktur gen.

Kodein lan produk metabolisme diekskresi utamane liwat ginjel lan menyang urin ing wangun asam glukuronat. Setengah urip yaiku 3-4 jam sawise ngombe utawa intramuskular. Kodein bisa dilebokake ing plasenta lan disebarake menyang ASI.

GuaiFenesin:

Sawise ngombe, obat kasebut nyerep kanthi apik saka saluran pencernaan. Ing getih, 60% obat kasebut dihidrolisis sajrone 7 jam. Metabolit kasebut ora aktif maneh lan diekskresi liwat ginjel. Sawise njupuk 400 mg guaifenesin, ora ana obat sing dideteksi ing bentuk utuh ing urin. Setengah saka umur Guaifenesin kira-kira 1 jam.

Sadurunge njupuk Obat Codcerin-D umur dawa nambani gejala batuk garing, batuk karo dahak, batuk alergi (2 blister x 10 tablet)

Cara nggunakake

Obat iki mung digunakake kaya sing diwenehake dening dokter.

Tablet digunakake kanthi lisan.

Dosis

Wong diwasa lan bocah luwih saka 12 taun: Njupuk 1 kapsul / wektu × 3 kaping / dina. Aja nggunakake luwih saka 6 kaping / dina. Aja nggunakake luwih saka 7 dina berturut-turut.

Bocah-bocah umur 12-18: Kanggo ngobati gejala garing utawa iritasi, codcerin -d ora dianjurake kanggo bocah sing duwe gangguan fungsi ambegan (ndeleng "ati-ati nalika digunakake").

Bocah-bocah ing umur 12 taun: codcerin-d sing dikontraindikasi kanggo nambani gejala garing utawa iritasi (pirsani bagean "Contraindications").

Cathetan: Dosis ing ndhuwur mung kanggo referensi. Dosis spesifik gumantung saka kahanan lan tingkat kemajuan penyakit kasebut. Kanggo dosis sing cocog, sampeyan kudu takon dhokter utawa spesialis medis.

Apa sing kudu ditindakake nalika overdosis?

Gejala: Inhibisi neurologis pusat kalebu inhibitor ambegan, gejala bisa berkembang nanging ora serius kajaba yen digabungake karo inhibitor neurologis pusat kayata alkohol utawa overdosis ing jumlah gedhe. Muntah, mual, pupil umum. Hipotensi lan tachycardia bisa kedadeyan nanging ora mesthi.

Manajemen: Kudu pulih ambegan kanthi menehi kontrol lan dhukungan ambegan. Coba nggunakake karbon aktif yen wong diwasa nggunakake luwih saka 350mg saben jam utawa overdosis 2.5mg / kg (loro bocah lan wong diwasa). Indikasi naloxon ing kasus koma utawa respirasi.

nglibatake Guaifenesin:

Gejala akut: Yen Guaifenesin digunakake tinimbang dosis sing luwih dhuwur tinimbang perawatan biasa, bisa nyebabake mual, muntah, rasa ora nyaman ing weteng.

Perawatan: Perawatan gejala lan dhukungan.

Kronis: Penyalahgunaan preparat sing ngandhut Guaifenesin bisa nyebabake watu ginjel.

Yen ana darurat, langsung nelpon puskesmas 115 utawa menyang puskesmas sing paling cedhak.

Apa sing kudu ditindakake yen sampeyan lali 1 dosis? Nanging, yen wektu kanggo ngendhokke karo dosis sabanjuré cendhak banget, skip dosis lan terus tanggalan tamba. Aja nggunakake dosis kaping pindho kanggo ngimbangi dosis sing ora kejawab.

Efek sisih

Nalika nggunakake obat kasebut, ana efek sing ora dikarepake (ADR) kayata:

kalebu kodein fosfat:

Neurologis: halusinasi, gelisah, nyegerake, samar, pusing, ngantuk, disorientasi, ketergantungan obat, sirah, pusing. Kejang empedu.

Sistem kekebalan: Reaksi hipersensitivitas kalebu gatal-gatal, urtikaria, ruam.

Kabari dokter babagan efek sing ora dikarepake nalika nggunakake obat.

Pènget

Before using the drug you need to read the instructions carefully and refer to the information below. contraindicated Codcerin-d drugs contraindicated in the following cases: Do not use cough treatment for people with asthma, respiratory failure. People are sensitive to the ingredients of the drug. Treatment of cough due to high risk of serious and life -threatening reactions. Be cautious when using need to be very careful when taking the drug for patients in the following cases: The drug contains sorbitol: Be careful when used for patients with allergies to some types of sugar. Objective reaction. Related to codeine phosphate: Codeine should only be used at the lowest doses that are effective and in the shortest time. It is not recommended to use codeine for children who have respiratory problems (for example: shortness of breath or wheezing when sleeping). Ask the doctor in the following cases: If you have a long -term or chronic cough, it may be a sign of a more severe condition. If you experience symptoms such as: feeling constipation, anorexia, fatigue, sleeping, shallow or slow, stop taking the medicine and call your doctor or pharmacist for advice. transformed through CYP2D6: Codeine is converted into morphine (active metabolites) through the liver enzyme CYP2D6 in the liver. If part or all of this enzyme is deficient, the patient will not achieve appropriate treatment effect. It is estimated that up to 7% of the white population may lack this enzyme. However, if the patient has a strong or super -fast metabolic metabolic gene, an increased risk of harmful reactions caused by opioid poisoning even in the usual prescription. These patients have the ability to convert codeine into morphine faster, leading to higher serum morphine levels than expected. The common symptoms of Opioid poisoning include consciousness, drowsiness, shallow breathing, pupils, nausea, vomiting, constipation and anorexia. In serious cases, symptoms of circulatory and respiratory decline may appear, may be life -threatening and rarely fatal. The estimated ratio of people carrying drug metabolism via CYP2D6 super fast in different races is summarized in the table below: racial ratio percentage% Á 1.2%to 2% Europe 1% to 2% Codeine is not recommended for use in children with respiratory function, including neuromuscular disorders, severe heart or respiratory diseases, upper and lung respiratory infections, multiple trauma or have just undergone major surgery. These factors can worsen the symptoms of Morphin's poisoning. The effect of the drug on the ability to drive and operate machinery The drug is likely to affect the ability to drive and operate machinery as well as working on high such as causing dizziness or drowsiness. Do not use drugs for people who are driving and operating machines as well as working on high. Using drugs for women during pregnancy and lactation pregnancy: Not used for pregnant women. breastfeeding period: codcerin-d is not recommended for women who are breastfeeding (see the "contraindication" section). In the usual dose of treatment, Codeine and metabolites can be present in breast milk at very low doses and does not seem to cause disadvantages to breastfeeding. However, if the patient is a super -fast CYP2D6 metabolic gene, Morphin (the active metabolite of the codeine) may be found in breast milk with higher concentrations and in very rare cases, which can lead to symptoms of opioid poisoning in newborns, which can cause death. Drug interaction involving codeine phosphate: Codeine increases the side effects of anti -Muscarin substances such as dry mouth, urinary retention, constipation (except for inhaled Muscarin resistant). rifampicin increases the metabolism of codeine. Like opioid groups, Codeine can increase the effects of sedatives such as barbiturat, anesthetic, painkillers, sleeping pills, sedatives and alcohol. can stimulate or inhibit the central nervous system when taking opioid analgesics with reversible IMAO inhibitors like Moclobemide. The sedative effect of Codeine can increase when used with three -ring antidepressants, painkillers, sleeping pills, or with antihistamine. Codeine can increase the effect of lowering blood pressure and sedation of anti -psychotic drugs. Monoaminase inhibitors Oxidase: IMAO is used with Pethidin that can stimulate or inhibit serious central nervous system (including hypertension or lower blood pressure). Although this is not recorded with codeine, it may occur similarly and therefore should avoid using Codeine when the patient is taking IMAO-B inhibitors and for 2 weeks after stopping the use of the drug. Anti -vomiting drugs: Codeine reduces bowel motility so it can slow down the absorption or causing the digestive tract reaction of anti -vomiting drugs for example Metoclopramid and domperidone. Cimetidine reduces the metabolism of codeine, leading to increased plasma medication concentration. Anti -arrhythmia: may reduce the absorption of Mexiletin or Quinidine at the digestive tract (so it can reduce the effect of codeine). Opioid analgesic drugs increase the effectiveness of sodium oxybate, used to treat sleeping eggs and should avoid simultaneous use of sodium oxybate with codeine. involving Guaifenesin: Do not coordinate Guaifenesin with substances similar to Guaifenesin in cough treatment. Using Guaifenesin may give a fake positive result in the vanillylmandelic acid measurement test (VMA) and 5-Hydroxyindoleacetic acid (5-HIAA) in the urine.

Panyimpenan

Panggonan sing garing, adhem, adoh saka srengenge, suhu ngisor 30 ° C.

Obat liyane

Disclaimer

Kabeh upaya wis ditindakake kanggo mesthekake yen informasi sing diwenehake dening Drugslib.com akurat, nganti -tanggal, lan lengkap, nanging ora njamin kanggo efek sing. Informasi obat sing ana ing kene bisa uga sensitif wektu. Informasi Drugslib.com wis diklumpukake kanggo digunakake dening praktisi kesehatan lan konsumen ing Amerika Serikat lan mulane Drugslib.com ora njamin sing nggunakake njaba Amerika Serikat cocok, kajaba khusus dituduhake digunakake. Informasi obat Drugslib.com ora nyetujoni obat, diagnosa pasien utawa menehi rekomendasi terapi. Informasi obat Drugslib.com minangka sumber informasi sing dirancang kanggo mbantu praktisi kesehatan sing dilisensi kanggo ngrawat pasien lan / utawa nglayani konsumen sing ndeleng layanan iki minangka tambahan, lan dudu pengganti, keahlian, katrampilan, kawruh lan pertimbangan babagan perawatan kesehatan. praktisi.

Ora ana bebaya kanggo kombinasi obat utawa obat sing diwenehake kanthi cara apa wae kudu ditafsirake kanggo nuduhake yen obat utawa kombinasi obat kasebut aman, efektif utawa cocok kanggo pasien tartamtu. Drugslib.com ora nanggung tanggung jawab kanggo aspek kesehatan apa wae sing ditindakake kanthi bantuan informasi sing diwenehake Drugslib.com. Informasi sing ana ing kene ora dimaksudake kanggo nyakup kabeh panggunaan, pituduh, pancegahan, bebaya, interaksi obat, reaksi alergi, utawa efek samping. Yen sampeyan duwe pitakon babagan obat sing sampeyan gunakake, takon dhokter, perawat utawa apoteker.