Gasmotin 5mg Eisai perawatan kanggo gastritis kronis (3 blisters x 10 tablet)

Bentuk sediaan Kothak 3 blister x 10 tablet
Spesifikasi Mosapride sitrat

Komposisi

Informasi komposisi	Isi
Mosapride sitrat	5 mg

Migunakake

Indications Gasmotin 5 mg is indicated in the following cases: Gastric - intestinal symptoms related to chronic gastritis (heartburn, nausea/vomiting). In the experiment of the empty gastric emptiness in healthy adults and patients with chronic gastritis, the only dose of these 5 mg increases the emptiness of the stomach. Stomach movement effect This drug increases gastric and duodenal movement after dog meals. The effect of enhancing stomach empty This drug enhances the emptiness of the stomach containing liquid (in mice and rats) and thick substances (in rats). The effect of enhancing the empty gastric hollow decreases after the dose is repeated for 1 week (in rats). Mechanism of impact This drug is a selective receptor owner 5 - HT4. The drug is thought to stimulate the receptor 5 - HT4 in the stomach -intestine plexus, increasing acetylcholin release, leading to enhancement of stomach movement and gastric emptiness. pharmacokinetic pharmacokinetics Plasma concentration (5 healthy adults fasting, single dose of 5mg mosapride citrate). tmax (h) cmax (ng/ml) t1/2 (hour) aUC0-∞ (ng*hour/ml) 0.8 ± 0.1 0.2 67 ± 8 The ratio of cohesion to plasma protein 99.0% [In test tubes, human serum, at a concentration of 1 μg/ml, super filter or balanced mental method]. Main metabolites and metabolic lines Main metabolites: DES-4-Fluorobenzyl compound. Metabolic line: Mosapride Citrate is metabolized mainly in the liver, where the 4-Fluorobenzyl group is taken away, followed by the oxidation of the morpholin ring in position 5, and the benzene hydroxide in position 3. The excretion line and the excretion ratio Excretion line: In urine and feces. The excretion ratio: In urine collected 48 hours after taking the drug, 0.1 % is excreted in the form of constant compound and 7.0 % is excreted in the form of aneurized metabolitus (DES-4-fluorobenzyl compound). (Healthy adults, single dose 5 mg Mosapride Citrate when hungry) Metabolic enzymes Cytochrome p-450 family: mainly CYP3A4.

Sadurunge njupuk Gasmotin 5mg Eisai perawatan kanggo gastritis kronis (3 blisters x 10 tablet)

Cara nggunakake

Gunakake oral karo segelas banyu, ngombe sadurunge utawa sawise mangan.

Dosis

Kanggo wong diwasa, dosis saben dina biasane 15 mg mosapride citrate ing wangun anhidrat, dibagi dadi 3 kaping sadurunge utawa sawise mangan.

Cathetan: Dosis iki bisa beda-beda gumantung saka pandhuane dokter. Dosis spesifik gumantung saka kahanan lan tingkat kemajuan penyakit kasebut. Kanggo dosis sing cocog, sampeyan kudu takon dhokter utawa spesialis medis.

Apa sing kudu ditindakake nalika overdosis?

Miturut asil panaliten nggunakake Gasmotin lisan kanggo wektu sing suwe ing spesies sing ditemoni (tikus sajrone 104 minggu lan tikus sajrone 92 minggu), dosis kasebut saka 30 nganti 100 mg / kg / dina 330 kaping luwih dhuwur tinimbang dosis klinis biasa, nuduhake peningkatan rasio tumor (tumor sel ati lan tumor sel kista tiroid).

Ngalami overdosis ing manungsa:

Ora ana data babagan overdosis, ora ana overdosis obat.

Overdosis:

Ora ana antidote khusus. Sampeyan kudu ngetrapake perawatan dhukungan umum ing kabeh kasus overdosis.

Yen ana darurat utawa overdosis, langsung nelpon puskesmas 115 utawa ngunjungi puskesmas sing paling cedhak.

Kajaba iku, sampeyan kudu nyathet lan nggawa dhaptar obat sing wis digunakake, kalebu obat resep lan non-resep.

Apa sing kudu ditindakake yen sampeyan lali dosis? Nanging, yen cedhak karo dosis sabanjure, skip dosis sing dilalekake lan njupuk dosis sabanjure ing wektu sing direncanakake. Aja ngombe kaping pindho kaya sing diwenehake.

Efek sisih

Nalika nggunakake Gasmotin 5 mg, sampeyan bisa ngalami efek sing ora dikarepake (ADR).

Ing uji klinis, efek samping dicathet ing 40 saka 998 kasus (4.0%). Efek samping utama yaiku diare / feces cair (1,8%), tutuk garing (0,5%), rasa ora nyaman (0,3%), lan liya-liyane. obat).

Efek samping klinis

Gangguan hepatitis akut, ati lan jaundice (saben jinis ngisor 0,1%).

Amarga hepatitis akut, disfungsi ati sing serius teka kanthi paningkatan AST (GOT), ALT (GPT) lan Gamma - GTP, lan sapiturute.

Klasifikasi gastrointestinal - saluran gastrointestinal diare/feces cair, tutuk garing, nyeri weteng, mual/muntah, owah-owahan rasa rasa distensi abdomen, rasa mati rasa ing tutuk (kalebu ilat lan lambe, lsp.) ALP, gamma-GTP lan Bilidrut liyane. angel urip, nambah trigliserida mlaku

Takon dhokter kanthi efek sing ora dikarepake nalika nggunakake obat.

Pènget

Sadurunge nggunakake obat kasebut, sampeyan kudu maca instruksi kasebut kanthi teliti lan deleng informasi ing ngisor iki.

Contraindicated

Gasmotin 5 mg contraindicated ing kasus ing ngisor iki:

Pasien kanthi riwayat hipersensitivitas kanggo Mosapride utawa komponen eksipien apa wae.

Pancegahan nalika nggunakake

nalika nyedhiyakake obat

Kanggo obat-obatan ing klik (PTP blister), pasien kudu diwulang mbusak obat saka blister sadurunge digunakake. [Kacathet yen ngulu tas PTP, sudhut sing cetha bisa nusuk mukosa esofagus, nyebabake komplikasi serius kayata mediastitis].

Ati-ati liyane

Nalika menehi tikus Mosapride Citrate kanthi dosis 100 nganti 330 kaping dosis dianjurake (yaiku 30 nganti 100 mg / kg / dina) kanggo wektu sing suwe (104 minggu ing tikus, 92 minggu ing tikus), diamati peningkatan rasio kelenjar sel ati lan kelenjar sel kista.

Kemampuan kanggo nyopir lan ora operate mesin. kacathet.

Kandhutan

ora kudu nggunakake obat iki kanggo wanita ngandhut, wanita bisa ngandhut, kajaba keuntungan sing dikarepake tinimbang risiko sing bisa ditindakake amarga perawatan. Keamanan obat iki kanggo wanita ngandhut durung kabukten.

Periode nyusoni

Aja nggunakake obat iki kanggo ibu sing nyusoni. Yen perlu kanggo nggunakake, ibu kudu mungkasi nyusoni sak perawatan. Eksperimen marang kewan (tikus) nuduhake obat kasebut diekskresikan liwat ASI.

Interaksi obat

Ati-ati nalika digunakake ing kombinasi (kudu ati-ati nalika nggunakake Gasmotin bebarengan karo obat ing ngisor iki.)

Narkoba

Tandha, gejala lan perawatan

mekanisme lan faktor risiko

Atropin Sulfat lan

Butylscopolamin bromid, lsp.

Panyimpenan

Simpen obat ing suhu kurang saka 30 ° C, ninggalake panggonan garing sing adhem, aja nganti cahya langsung, nyegah kelembapan.

Obat liyane

Disclaimer

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