MaxxNeuro 75 Amharco perawatan nyeri saraf, epilepsi lokal (3 blister x 10 tablet)

Bentuk sediaan Kothak 3 blister x 10 tablet
Spesifikasi Pregabalin

Komposisi

Informasi komposisi	Isi
Pregabalin	75 mg

Migunakake

indikasi

Perawatan nyeri neurologis ing neuropati perifer.

Perawatan nyeri ing kene sawise infeksi virus herpes. Ndhukung perawatan kanggo pasien diwasa kanthi epilepsi lokal.

Perawatan nyeri awak (fibrosis otot).

Perawatan nyeri saraf ing karusakan sumsum balung mburi.

Farmakologi

Pregabalin nyambungake afinitas dhuwur menyang lokasi Alpha2-Delta (1 sub-unit saka gerbang saluran kalsium gumantung) ing jaringan sistem saraf pusat. Iki bisa uga ana gandhengane karo nyuda rasa nyeri lan anti-kejang ing kéwan animabalin. Ing model karusakan saraf kewan, pregabalin ditemokake kanggo nyuda pelepasan katergantungan kalsium saka neurotransmitter sadurunge reseptor nyeri ing sumsum tulang belakang, bisa uga kanthi ngilangi transportasi liwat saluran kalsium kanthi unit alpha2-delta lan / utawa nyuda garis kalsium. Bukti saka model karusakan saraf lan nyeri sing terus-terusan ing kewan liya sing nyaranake nyeri analgesik liwat reseptor nyeri Pregabalin uga bisa dadi perantara penengah kanthi jalur mudhun Noradrenergik lan Serotonergic saka batang otak, ngatur transmisi sensori ing sumsum tulang belakang. Sanajan Pregabalin minangka turunan struktural saka Gamma Aminobutyric Acid (GABA), ora langsung nempel langsung menyang reseptor GABAA, GABAB, utawa Benzodiazepine, ora nambah respon GABAA, ing neurosus sing ditanem, konsentrasi Gabaa sing ora owah ing otak utawa efek akut ing akuisisi, resesi utawa resesi sing dawa. sel saraf sing ditanem nambah kapadhetan protein khusus gaba lan nambah kacepetan fungsi GABA.

Farmakokinetik dinamis

Pregabalin diserap kanthi apik sawise lisan, konsentrasi puncak ing plasma diraih sawise 1,5 jam. Bioaktivitas oral Pregabalin ≥ 90% lan ora gumantung ing dosis. Status stabil diraih sajrone 24-48 jam sawise dosis diulang. Tingkat panyerepan Pregabalin dikurangi nalika digunakake karo panganan, ndadékaké CMAX mudhun udakara 25-30% lan TMAX tahan nganti 3 jam. Nanging, nggunakake pregabalin bebarengan karo panganan ora duwe efek ing total panyerepan pregabalin klinis. Mula, Pregabalin bisa ngombe nalika luwe utawa karo panganan.

Pregabalin ora ana hubungane karo protein plasma. Ing manungsa, volume distribusi Pregabalin sawise nggunakake lisan kira-kira 0,5 l / kg. Pregabalin minangka landasan kanggo transportasi L-sistem sing tanggung jawab kanggo ngangkut asam amino gedhe liwat alangi getih otak. Sanajan ora ana data ing manungsa, wong pregabalin wis ngliwati alangan getih ing tikus, tikus lan kethek. Kajaba iku, pregabalin ngliwati plasenta ing tikus lan katon ing susu tikus sing ngandhut.

Pregabalin ora dimetabolisme ing awak manungsa, kira-kira 90% saka dosis sing ditemokake ing urin yaiku Pregabalin kanthi bentuk konstan. Derivatif n-methylate Pregabalin, metabolit utama Pregabalin ditemokake ing urine, kira-kira 0,9% saka dosis.

Pregabalin kajaba kanggo sistem sirkulasi utamane amarga ekskresi liwat ginjel ing wangun ora owah kanthi rata-rata wektu sade 6,3 jam ing wong sing fungsi ginjel normal. Reresik rata-rata kira-kira 67,0 nganti 80,9 ml / menit ing wong enom sing sehat. Eliminasi pregabalin meh sebanding karo reresik kreatinin (CLCR). Ngurangi dosis ing pasien kanthi disfungsi ginjel utawa hemolisis perlu. Pregabalin diilangi saka plasma kanthi efektif kanthi hemolisis.

Sadurunge njupuk MaxxNeuro 75 Amharco perawatan nyeri saraf, epilepsi lokal (3 blister x 10 tablet)

How to use maxxneuro is taken with food or not. When stopping treatment with MaxxNeuro, it is necessary to stop slowly for a minimum of 1 week. Dosage Neurological pain in peripheral neuropathy due to diabetes The maximum recommended dose of MaxxNeuro is 100 mg, 3 times/day (300 mg/day) in patients with a minimum creatinine clearance of 60 ml/min. Starting at a dose of 50 mg used 3 times /day (150 mg /day). Dosage may increase after 1 week of treatment depending on the response of patients up to 300 mg/day. Neuropathy after the herpes virus infection Maxxneuro's recommended dose is 75 dén 150 mg, 2 times/day, or 50 to 100 mg, 3 times/day (150 to 300 mg/day) on patients with a minimum creatinine clearance of 60 ml/minute. Start at a dose of 75 mg, 2 times/day, or 50 mg, 3 times/day (150 mg/day). The dose increases after 1 week of treatment depending on the response of the patient to 300 mg/day. Patients do not relieve much pain after 2 to 4 weeks of treatment at a dose of 300 mg/day, and can tolerate MaxxNeuro, can increase the dose to 300 mg, 2 times/day, or 200 mg, 3 times/day (600 mg/day). Support therapy for adult patients with local epilepsy Proposing patients to start the total daily dose does not exceed 150 mg/day (75 mg, 2 times/day, or 50 mg, 3 times/day). Dosage can increase after 1 week of treatment depending on the response of patients up to 300 mg/day and after another week, it may increase to the dark dose of 600 mg/day. Treatment of body aches (muscle fibrosis) Maxxneuro's recommended dose for body aches and pains is 300 to 450 mg/day. Start at a dose of 75 mg, 2 times/day (150 mg/day). Dosage may increase after 1 week of treatment depending on the response of patients up to 150 mg 2 times/day (300mg/day). Patients must reduce pain in a dose of 300 mg/day, which may increase the dose to 225 mg, 2 times/day (450 mg/day). Although Pregabalin has been studied at a dose of 600 mg/day, there is no evidence that this dose is beneficial for patients and this dose is less tolerated. Treatment of nerve pain in spinal cord injury The initial recommended dose is 75 mg, 2 times/day (150 mg/day). The dose may increase after 1 week of treatment depending on the response of patients up to 150 mg 2 times/day (300 mg/day). Patients do not relieve much pain after 2 to 3 weeks of treatment at a dose of 150 mg twice a day, and can tolerate MaxxNeuro can increase the dose to 300 mg, 2 times/day. Patients with renal failure: Table 1. Adjust the dose of pregabalin by kidney function. Dose reduction in patients with renal dysfunction is necessary. Creatinine clearance (CLCR) (ml/min) Total daily Pregabalin dose (mg/day)* Treatment regimen Time/day Time/day 15-30 25-50 75

Efek sisih

Umum, ADR> 1%

Awak: lara weteng, reaksi alergi, mriyang.

Sistem pencernaan: Gastritis, nambah napsu, tutuk garing, konstipasi, kembung, muntah, mual.

Pembuluh getih lan getah bening: Getih.

Kelainan nutrisi-kimia: lapisan periferal, gain bobot, lapisan, retensi cairan, hipoglikemia.

Sistem otot: nyeri sendi, kerak ing sikil, nyeri otot, kelemahan otot; Nyeri punggung, kejang otot.

Sistem saraf: kuatir, mundhut pribadine, nyuda sensasi, nyuda seksualitas, geter bola mata, paresthesia, sedasi, bingung, konvulsi, pusing, ngantuk, mundhut AC, sirah, geter, pikiran abnormal, gangguan keseimbangan, gangguan neurologis, gait abnormal, kebingungan, kekirangan, kekirangan.

Kulit lan tambahan: gatel.

Panca indera: konjungtivitis, penglihatan ganda, otitis media, tinnitus, penglihatan kabur, nyeri laring.

Sistem saluran kemih: Gangguan rasa seneng, impotensi, urination, urin sing ora bisa dikontrol.

Ora umum, 1%

Sistemik: abses, inflamasi sel, kedinginan, rasa ora nyaman, gulu kaku, nyeri panggul, reaksi sensitif cahya.

Sistem kardiovaskular: embolisme vena jero, gagal jantung, hipotensi, postur hipotensi, kelainan pembuluh darah retina, pingsan.

Sistem gastrointestinal: cholecystitis, watu empedu, kolitis, angel ngulu, esofagitis, gastritis, getihen gastrointestinal, feces ireng, ulkus tutuk, pankreatitis, pendarahan rektum, busung ilat.

Sistem vaskular lan limfatik: Anemia, hipergai, blemishes, nodus limfa, leukemia. penyakit sendi.

Sistem saraf: impen sing ora normal, bingung, apatis, ilang basa, kelainan ing cangkeme, kelainan basa, halusinasi, oposisi,

Tambah nyeri, tambah sensitivitas, hiperaktif hiperaktif, nada nyuda, nambah seksualitas, geter otot, nyeri saraf.

Kulit lan appendages: botak, kulit garing, eksim, dheweke, ulkus kulit, urtikaria, ruam bulosa.

Panca indera: pangaturan abnormal, inflamasi bulu mata, mripat garing, bola mata, hiperplasma pangrungu, wedi marang cahya, edema retina,

ilang rasa, gangguan rasa.

Sistem saluran kemih: ejakulasi abnormal, albumin diuretik, amenore, dysmenorrhea, angel nguyuh, urination getih, watu ginjel, getih putih, menorrhagia, pendarahan, glomerulonefritis, uretra, retensi urin, kelainan urin.

Langka, ADR

Sistemik: reaksi anafilaksis, panel abdomen, granuloma, mabuk ora nyaman, kejut.

Sistem kardiovaskular: St beda, geter.

Sistem gastrointestinal: Turian stomatitis, ulcer esofagus, abses periodontal.

Pembuluh getih lan sistem limfatik: fibrosis, sel getih abang, protrombin mudhun, pendarahan, trombosit.

Gangguan nutrisi-kimia: Ngurangi toleransi glukosa, kristal urin.

Sistem otot balung: displasia rawan, kejang kabeh.

Sistem saraf: Kecanduan, sindrom cerebellar, koma, khayalan, khayalan, kelainan neurologis tanduran, kelainan gerakan, kelainan otot, patologi otak, sindrom menara asing, sindrom Guillain-Barré, nyuda rasa nyeri, tekanan intrakranial, sedih abnormal, paranoia, neuritis perifer, gangguan kepribadian, gangguan turu, gangguan turu, gangguan turu

Sistem pernapasan: apnea, bronkitis, cegukan, kejang laring, edema paru, fibrosis paru, menguap.

Bagian kulit lan sisih: angioedema, dermatitis peeling, melanoma, penyakit kuku, pendarahan, ruam gatal, atrofi kulit, nekrosis kulit, tumor kulit, sindrom Stevens-Johnson.

Panca indera: pupil sing ora teratur, wuta, ulkus kornea, mripat cembung, paralisis otot ing njaba jembatan, kornea, inflamasi pupil, kornea, iritasi. wuta, longan, atrofi ophthalmic, atrofi saraf hemoragik, semangat, mambu, bulu mata rontok, uveitis.

Sistem urin-seks: Gagal ginjel akut, inflamasi kulup, tumor kandung kemih, serviks, nyeri hubungan seksual, epididimitis, sekresi susu ing wanita, glomerulonefritis, kelainan ovarium, pielonefritis.

Tandhani dhokter babagan efek ala nalika njupuk obat kasebut.

Pènget

Sadurunge nggunakake obat kasebut, sampeyan kudu maca instruksi kasebut kanthi teliti lan deleng informasi ing ngisor iki.

Kontraindikasi

Pasien kanthi hipersensitivitas kanggo pregabalin utawa bahan apa wae ing formula.

Ati-ati nalika nggunakake

ngawasi katon utawa rusak saka depresi, pikiran lampus, utawa prilaku ora normal liyane.

Ngawasi kenaikan bobot lan/utawa cairan cairan, bisa dadi luwih elek utawa nyebabake gagal jantung. Kasebut kanthi teliti, priksa riwayat penyalahgunaan pasien lan deleng pratandha yen dheweke nggunakake salah utawa penyalahgunaan Pregabalin.

Bocah-bocah: Keamanan lan efektifitas durung diverifikasi.

Wong tuwa: Amarga fungsi ginjel cacat sing ana gandhengane karo umur, dosis bisa diatur.

Gagal jantung: Wigati nalika digunakake kanggo pasien jantung karo NYHA III utawa IV.

Tambah creatine kinase wis direkam. Mungkasi nggunakake pregabalin yen diagnosis utawa dicurigai penyakit otot utawa tingkat creatine kinase mundhak sacara signifikan.

Trombosit sing signifikan sacara klinis wis dilaporake.

Mungkasi perawatan: Mungkasi obat kasebut alon-alon (paling ora 1 minggu) kanggo nyuda kemungkinan nambah frekuensi bocah ing pasien kejang. Insomnia, mual, sirah, lan diare wis dicathet nalika mungkasi obat kanthi cepet utawa dumadakan.

Dampak ing mripat: Ngurangi sesanti, owah-owahan pasar, lan owah-owahan nalika ndeleng bagian ngisor mripat wis dicathet.

edema perifer: wis kacathet. Asring dumadi ing pasien sing njupuk pregabalin lan obat diabetes Thiazolidinedione.

ngluwihi jangkoan PR (3 nganti 6 milidetik) wis direkam; Bentenane rata-rata ora diiringi paningkatan risiko PR ngluwihi PR luwih saka 25% dibandhingake karo asline, nambani PR luwih saka 200 milidetik, utawa nambah risiko kloning atrium atrium loro utawa telu.

Risiko pikiran utawa prilaku bunuh diri bisa disumbang. Iki bisa uga katon ing awal minggu pisanan sawise wiwitan perawatan lan terus sajrone perawatan.

Tambah bobot wis dicathet.

Efek obat kasebut ing kemampuan kanggo nyopir lan ngoperasikake mesin

maxxneuro bisa nyebabake pusing utawa ngantuk, sesanti kabur lan gejala neurologis pusat liyane, pasien disaranake supaya ora nyopir, ngoperasikake mesin rumit utawa melu aktivitas petualangan liyane nganti nemtokake manawa obat kasebut duwe efek ngaruh ing mental, sesanti, lan / utawa lactation wanita nalika meteng.

Wong wadon meteng

Ora ana studi kontrol lengkap babagan wanita ngandhut. Aja nggunakake Pregabalin nalika meteng kajaba keuntungan menehi ibu luwih jelas luwih penting tinimbang risiko sing bisa kedadeyan kanggo janin.

Nalika nyusoni

Ora dingerteni manawa pregabalin diekskresi ing susu manungsa utawa ora; Nanging, obat kasebut katon ing susu tikus. Amarga kemampuan kanker pregabalin ing kewan, penting kanggo nggatekake pentinge obat kasebut kanggo para ibu kanggo mutusake mandheg nyusoni utawa mandheg ngombe obat kasebut.

Obat interaktif

digunakake karo inhibitor sing ditransfer (contone, captopril) bisa nambah risiko angioed lan urtikaria. Hubungi staf medis sanalika gejala kasebut katon.

Pasien kudu diobati nganggo inhibitor saraf pusat (umpamane, alkohol, Lorazepam, Oxycodone) bisa ndeleng efek liyane ing fungsi motorik kognitif lan mentah. Aja nggunakake alkohol, bir.

Pregabalin lan Thiazolidinediones (contone, pioglitazone) bisa nyebabake bobot lan/utawa cairan, sing bisa dadi luwih elek utawa nyebabake gagal jantung. Wigati nalika nggunakake. Monitor pasien. Yen ana anggepan interaksi obat, bisa uga mbutuhake dosis siji utawa loro obat.

Panyimpenan

Ninggalake papan sing adhem, aja nganti cahya, suhu ngisor 30⁰C.

Supaya ora bisa digayuh bocah, waca manual pangguna kanthi teliti sadurunge digunakake.

Obat liyane

Disclaimer

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