Quinine Sulphate 250mg Mekophar Pengobatan malaria (180 tablet)

Bentuk sediaan Box isi 180 kapsul
Spesifikasi Quinin sulfate

Komposisi

Informasi komposisi	Isi
Quinin sulfate	250 mg

Migunakake

Indikasi

Quinininin Sulfate 250 mg dituduhake ing kasus ing ngisor iki:

Pengobatan malaria tanpa komplikasi amarga P. Falciparum. Plasmodium Falciparum, P. Vivax, P. Ovale, P. Malariae, nduweni pengaruh cilik ing awak lan sel getih abang. Obat kasebut nduweni efek mateni gamet P. Vivax, P. Malariae, tanpa efek mateni gamet P. Falciparum. Mula aja nganggo quinin kanggo nyegah penyakit.

kina beracun, efek kurang saka klorokuin ing kamar lan nambani malaria nanging nduweni nilai khusus kanggo nambani malaria abot lan malaria ganas sing disebabake dening klorokuin tahan P. Falciparum utawa disebabake galur multi-tahan.

Quinin uga bisa tahan khusus kanggo P. Falciparum, ing perawatan kudu digunakake kanthi kombinasi karo pembunuh skizofrenia ing getih sing kerjane luwih alon kaya sulfadoxin utawa tetracyclin.

Mekanisme aksi quinin marang parasit malaria yaiku nyegah sintesis asam nukleat utawa nyuda fungsi target. Quinine nyuda penyerapan oksigen lan metabolisme karbohidrat, ngganggu senar DNA, ngganggu proses replikasi lan transkripsi parasit.

farmakokinetik

Nalika ngombe uyah Quinin, ing wong diwasa sing sehat, 76 - 88% saka obat kasebut diserap ing getih lan tekan konsentrasi maksimal sawise 1 jam. Penyerapan obat kurang kena pengaruh panganan nanging alon dening obat anti-asam aluminium lan/utawa magnesi.

Ing malaria, panyerepan obat sing luwih dhuwur tinimbang wong sing sehat, bisa uga amarga malaria ngganggu fungsi ati, sing nyebabake nyuda reresik awak lan nyuda distribusi obat kasebut. Koefisien clearance suda luwih saka volume distribusi, mula wektu sale mundhak udakara 11 - 18 jam.

Quinin gampang nyebar menyang jaringan janin, metabolisme ing ati.

quinin sulfate diowahi dadi 4 zat utama, yaiku, 3-hygroxyquinin minangka zat metabolisme utama kanthi aktivitas sing luwih murah tinimbang Quinin Sulfate.

Quinin diekskresi utamane liwat ginjel kanthi rasio

Sadurunge njupuk Quinine Sulphate 250mg Mekophar Pengobatan malaria (180 tablet)

How to use Quinin Sulfate 250 mg oral. Should take Quinin Sulfate 250 mg during meals to reduce the digestive tract irritation. In case of vomiting, should use injection. Dosage Dosage: Quinin sulfate 250 mg by weight: 30 mg quinin sulfate/kg/24 hours, divided 3 times/day, for 7 days. Dosage Quinin sulfate 250mg in age group without weight: age group Number of tablets/day x Date number Notes 1 tablet/day x 7 days Divide 3 times a day 1 - Under 5 years old 1 quarter/day x 7 days 5 - Under 12 years old 3 tablets/day x 7 days 5 tablets/day x 7 days 6 tablets/day x 7 days Falciparum, must not use a simple malaria drug, must be coordinated to limit drug resistance and increase the effectiveness of healing, quinine is often coordinated with clindamycin, tetracycline or Doxycycline. Combining Quinin Sulfate with DoxycyCline (each tablet contains 100 mg of DoxycyClin): only used to combine Quinin Sulfate with DoxycyCline in adults and children over 8 years old. Take Quinin with the above dose, combined with Doxycyclin: Doxycycline dose of 100 mg tablets calculated by weight: 3 mg doxycyclin/kg/day, oral 1 time/day, used for 7 days. Doxycycline dose of 100 mg tablets calculated by age group if no weight: Age group Number of tablets/day x Date number 8 - Under 12 years old 1 quarter/day x 7 days 4 tablets/day x 7 days 1 tablet/day x 7 days Take Quinin with the above dose, combined with clindamycin: Clindamycin dose of 150 mg tablets and 300 mg tablets calculated by weight: 15 mg Clindamycin/kg/day, divided 2 times/day, used for 7 days. Clindamycin dose of 150 mg tablets and 300 mg tablets in age group if no weight: Number of tablets/day x Date number age group tablets 300 mg Clindamycin under 3 years old 1 tablet/day x 7 days ½ capsules/day x 7 days 1 quarter/day x 7 days ¾/day x 7 days 2 tablets/day x 7 days 1 tablet/day x 7 days 3 tablets/day x 7 days 1 quarter/day x 7 days 4 tablets/day x 7 days 2 tablets/day x 7 days along the tablet for the dose ¾. hydrochloride). Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist. What to do when overdose? Overdose symptoms may appear after 1 hour or longer medication. The lesions left in the eye are the most severe manifestations, the common symptoms in the eye are reduced the concentric market or the dark spot. The QRS complex may be expanded, arrhythmia, sometimes T waves are sound, curly ventricular arrhythmia. Hematuria has been encountered in acute heart failure. In some cases, after 24 hours of severe arrhythmia. Black urine fever is often due to chronic poisoning caused by Quinine, severe hemolysis, hemoglobin, hemoglobin, otherwise cure can cause kidney failure and death. Handling Mainly treat symptoms and support, pay attention to maintaining blood pressure, respiration, kidney function and cure arrhythmia. Measures include: Limit absorption: Take activated carbon, dose 25 - 50 g (within 2 hours after taking the medication), gastrointestinal - intestines. Increased excretion: Take activated carbon in the form of granular, start drinking 50 g and then drink 25 g every 4 hours, repeat many times. Acid urinary tract, hemorrhage, blood transfusions, plasma changes are not effective in increasing quinine elimination. Preventing or restoring retinal damage by taking vasodilators and closing lymph nodes. Cases of severe heart poisoning: Using muscle contraction drugs such as isoprenalin, dopamine or prenalterol. Treatment of convulsions: Use Diazepam 5 - 10 mg, children use 0.1 - 0.2 mg/kg body weight. Treatment of arrhythmia, level and heart condition. What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Efek sisih

Nalika nggunakake Quinin Sulfate 250 mg, sampeyan bisa ngalami efek sing ora dikarepake (ADR).

Efek sing ora dikarepake amarga dosis sing dhuwur utawa bisa uga amarga reaksi hipersensitivitas lan alergi pasien.

Ora umum, 1/1000

Awak kabeh: Hipersensitivitas (sindrom Canhkina) diwujudake kanthi gejala tinnitus, gangguan pangrungu sauntara, sirah, mual, penglihatan kabur utawa kelainan warna.

Sistem saraf pusat: stimulasi, delirium, kuatir.

Pencernaan: Muntah, nyeri weteng, diare, anoreksia.

Pernafasan: Kesulitan ambegan, asma, angina.

musculoskeletal: kelemahan otot, nyeri otot.

Kardiovaskular: blok atrium - ventrikel, bradikardia, drum dada, qt sing dawa, tekanan getih mudhun, pingsan.

Badan : Demam.

getih: Anemia, trombositopenia, granulositosis, anemia, penurunan protrombin, hemolitik, pendarahan, sindrom hiperemia lan hemolisis, gangguan koagulasi getih, nyuda getih perifer.

Kulit: Njaba, urtikaria, sindrom Stevens - Johnson, nekrosis epidermis keracunan.

ginjel: Gagal nefrotik, nefritis interstitial, hemoglobin urin.

Hepatitis: Hepatitis, hepatitis granular, jaundice.

Takon dhokter babagan efek sing ora dikarepake nalika nggunakake obat kasebut.

Pandhuan babagan cara nangani ADR

Nalika ngalami efek samping obat kasebut, sampeyan kudu mandheg nggunakake lan ngandhani dhokter utawa menyang fasilitas medis sing paling cedhak kanggo perawatan pas wektune.

Pènget

Sadurunge nggunakake obat sampeyan kudu maca instruksi kasebut kanthi teliti lan deleng informasi ing ngisor iki.

Contraindicated

Quinininin Sulfate 250 mg contraindicated ing kasus ing ngisor iki:

Ana riwayat sensitivitas kanggo Quinin, Quinidin utawa Mefloquin utawa bahan obat apa wae.

alergi marang omben-omben sing ngandhut quinin minangka rempah-rempah.

kekurangan G6PD.

Pancegahan nalika nggunakake

karo pasien ing ngisor iki kudu ngawasi lan nyuda dosis:

Ana hipersensitivitas kanggo Quinin, Quinidin utawa Mefloquin, utamane yen ana gejala ing kulit, angioedema, gejala visual utawa pendengaran.

Pasien karo atrial - ventrikel, aritmia, penyakit jantung sing abot, kurang G6PD amarga bisa nyebabake larut getih, demam urin ireng, hipoglikemia, gagal ginjel.

Mungkasi obat kasebut yen sampeyan ndeleng gejala hemolitik.

Ati-ati kanggo pasien sing duwe kelainan genetik langka ing toleransi galaktosa, defisiensi laktase utawa gangguan penyerapan glukosa-galaktosa.

Kemampuan kanggo nyopir lan ngoperasikake mesin

Pancegahan nalika digunakake kanggo sopir sepur lan mesin operasi amarga obat kasebut bisa nyebabake

sesanti utawa tinnitus sing kabur nalika katon kabur utawa owah-owahan warna.

Kandhutan

Sajrone meteng mung nggunakake obat iki nalika nandhang malaria ganas sing abot lan ora ana obat liya sing bisa nylametake nyawa pasien.

Nalika nggunakake dosis perawatan: Quinin ora nyebabake cacat nalika lair, nanging nambah insulin lan bisa nyebabake hipoglikemia abot ing wong ngandhut. Quinin bisa nyebabake thrombocytopenia ing ibu lan bayi sing nembe lair, sing bisa nyebabake hemolisis amarga G6PD ing bayi.

Periode nyusoni

Quinin diekskresikan kanthi jumlah cilik liwat susu. Njupuk dosis 300 mg lan 640 mg, konsentrasi maksimal ing susu yaiku 2,2 mikrogram / ml, rata-rata 1 mikrogram / ml sawise 3 jam. Ora ana efek ala nalika nyusoni, mula Quinin bisa digunakake karo ibu-ibu sing nyusoni. Mung nggunakake obat-obatan yen pancen perlu lan entuk manfaat sing luar biasa.

Interaksi obat

antasida sing ngandhut aluminium lan/utawa magnesi bisa nyandhet panyerepan quinin pencernaan, mula kudu dipisahake rong obat.

Amarga interaksi ing ngisor iki bisa uga kudu nyetel dosis ing perawatan:

cimetidine nyuda retensi ginjel lan nambah setengah umur quinin, saengga nambah konsentrasi kina ing plasma. Ranitidine duwe efek cilik.

rifampicin bisa nambah tingkat ekskresi kina nganti 6 kaping, nyuda konsentrasi kina plasma.

Obat-obatan sing nyebabake asam urat bisa ningkatake ekskresi kina menyang urin.

quinin alon-alon nyerep lan nambah konsentrasi digoxin plasma lan glikosida jantung sing gegandhengan. Quinin nambah konsentrasi warfarin ing plasma lan antikoagulan sing gegandhengan.

kina nambah efek saka saraf - obat maple otot lan antagonis karo inhibitor acetylcholinininthininthinines, sing disebabake kina ing titik sambungan saraf-otot.

Tambah risiko aritmia ventrikel yen quinin digunakake karo halofantrin utawa anti-arrhyths kayata amiodaron, obat antihistamin Astemizol, Terfenadin, Cisaprid lan obat psikotik PimozID.

bisa nambah risiko konvulsi utawa aritmia ventrikel abot nalika nggunakake quinin karo mefloquin.

Aja nggunakake antibiotik makrolid bebarengan (eritromisin, troleandomycin), ritonavir (amarga tambah konsentrasi, nyuda reresik kina), Artemether, Lumefantrin, Conivaptan, Silodosin, Topotecan.

Panggunaan kina bebarengan karo Atorvastatin bisa nambah risiko penyakit otot utawa otot.

quinin bisa nyuda efek codeine, tramadol.

Sawetara jamu sing sesambungan karo Quinin bisa nyuda konsentrasi Quinin ing getih (St. John's Wort) utawa bisa nyebabake tekanan getih luwih murah (California opium, lenga frekuensi, hemp, mistletoe, klapa cethek).

ketokonazol nambah panyerepan, nyuda konsentrasi quinin nalika digunakake bebarengan.

Panyimpenan

Ing panggonan sing garing, aja nganti cahya, suhu ora ngluwihi 30 ° C.

Tanggal kadaluwarsa: 60 sasi saka tanggal produksi. Aja nggunakake obat telat sing wis kasebut ing kemasan.

Obat liyane

Disclaimer

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