SIFSTAD 0.18mg Stella nambani pratandha lan gejala penyakit Parkinson (3 blister x 10 tablet)

Bentuk sediaan Kothak 3 blister x 10 tablet
Spesifikasi Pramipexole

Komposisi

Informasi komposisi	Isi
Pramipexole	0,18 mg

Migunakake

Indikasi

Obat SIFSTAD dituduhake ing kasus ing ngisor iki:

Pangobatan diwasa kanggo nambani pratandha lan gejala penyakit Parkinson idiopatik, nggunakake monomer (ora karo levodopa) utawa gabungke karo Levodopa, sing tegese bisa digunakake sajrone perawatan, nganti tahap pungkasan nalika efek Levodopa mboko sithik dadi ora stabil lan katon ora stabil ing efek perawatan (ing pungkasan dosis utawa osilasi. ")

Pangobatan gejala ing wong diwasa sindrom vakum sing ora nyaman ora basis wis abot nganti dosis nganti 0,54mg basa (0,75mg uyah).

Farmakokologi

pramipexol minangka pemilik dopamin non-turunan saka jamur spurs pitik (nonergot) kanthi pemantauan in vitro sing dhuwur lan nduweni aktivitas internal lengkap karo klompok reseptor Dopamin D2, kanthi prioritas kanggo grup reseptor D3 utawa D4.

Mekanisme pengaruh penyakit Parkinson sing tepat kanggo penyakit Parkinson: Pramipexol. dikenal, bisa uga amarga kemampuan kanggo ngrangsang reseptor dopamin ing pola kasebut.

Sindrom vakum tentrem (HCCKY): Mekanisme dampak sing tepat Pramipexol ing perawatan HCCKY durung dingerteni. Sanajan fisiologi medis HCCKY ora dingerteni, bukti farmakologi neuroscientific nuduhake manawa ana keterlibatan utama sistem dopaminergik. Kelainan fungsional dhuwit dopaminergik Synap ing wangun pola entheng bisa uga ana hubungane karo patologi HCCKY.

farmakokinetik

Pramipexol gampang diserap liwat saluran pencernaan lan konsentrasi puncak ing plasma diraih sajrone 2 jam ing pasien sing keluwen lan kira-kira 3 jam nalika nggunakake panganan sing padha. Bioavailability lisan kira-kira 90%. Pramipexol disebarake ing saindhenging awak lan ngiket protein plasma ing ngisor 20%. Metabolisme cilik lan luwih saka 90% dosis dibuwang liwat tubulus ginjal menyang urin ing bentuk non-metabolik. Wektu sade yaiku saka 8 nganti 12 jam. Panaliten tikus nuduhake yen obat kasebut disebar ing ASI.

Sadurunge njupuk SIFSTAD 0.18mg Stella nambani pratandha lan gejala penyakit Parkinson (3 blister x 10 tablet)

How to use SIFSTAD is used by water with water, or not with food. Dosage Parkinson's disease Daily dose is divided equally to drink 3 times a day. Starting treatment The dose increases slowly, the starting dose is 0.264mg of base form (1 12 sifstad 0.18)/day, and then increasing the dose gradually every 5-7 days. If the patient does not have the side effects that cannot be tolerated, should increase the dose gradually until the maximum treatment is achieved. schedule to increase the dose of pramipExol week dose (mg Base) Total daily dose (mg) dose (TD) Salt 0.54 0.75 3x1 Sitstad 0.18 or 3 x 14 Sitstad 0.7 tablets 0.7 0.7)/day. However, it should be noted that the drowsiness rate will increase when the dose is higher than 6 sifstad 0.18 or 1 12 SIFSTAD 0.7/day. Maintain treatment Dosage for each patient should be in the range of 0.264mg of base form (1 12 sitstad 0.18 tablets) to a maximum of 3.3mg of base form (18 sitstad 0.18 tablets or 4 12 sifstad 0.7)/day. In the process of increasing the dose in key studies shows the effectiveness started from the dose of 1.1mg of base (6 sifstad 0.18 tablets or 12 sifstad 0.7). Additional adjustment should be based on clinical response and the appearance of unwanted effects. Recommendations to reduce the dose of levodopa in both cases of increasing dose and maintenance treatment Pramipexol depending on the reaction of each patient. Stop treatment Sudden stopping dopaminergic therapy can lead to malignant neuroleptic syndrome, a decrease in pramipexol dose at a speed of 0.54mg of base form (3 SIFSTAD 0.18 or 34 Sitstad 0.7)/day until the daily dose reaches 0.54mg of base form (3 SIFSTAD 0.18 or 34 SIFSTAD 0.7 tablets). After that, it is necessary to reduce the dose to 0.264mg of base form (1 12 sitstad 0.18)/day. Patients with renal failure Pramipexol elimination depends on the kidney function. Below is a dosage suggested at the beginning of treatment: Patients with creatinine clearance above 50ml/minute do not need to reduce daily dose or frequency of drugs. Patients with creatinine clearance about 20 - 50ml/min, the daily dose of pramipexol treatment must be divided into drink twice, starting at a dose of 0.088mg of base form (12 sifstad 0.18) x 2 times/day. The maximum daily dose does not exceed 1.57mg of base form (9 sifstad 0.18 tablets or 2 12 sifstad 0.7 tablets). Patients with creatinine clearance below 20ml/min, daily dose of pramipexol should be taken once, starting at a dose of 0.088mg base (12 sifstad 0.18)/day. The maximum daily dose does not exceed 1.1mg of base form (6 sitstad 0.18 tablets or 1 12 sifstad 0.7 tablets). If the renal function decreases during maintenance treatment, it is necessary to reduce the daily dosage of pramipexol in the same proportion to the decline of creatinine clearance, if the creatinine clearance decreases by 30%, the daily dosage of pramipexol also decreases by 30%. The daily dose can be divided into twice if the creatinine clearance is about 20 - 50ml/min and drink once a day if the creatinine clearance is less than 20ml/min. Patients with liver failure There is no need to adjust the dose in patients with liver failure. Children Safety and effectiveness of pramipexol in children under 18 have not been set up. Something impatient syndrome The recommended starting dose of Pramipexol is 0.088mg of base form (12 sitstad 0.18) x 1 time/day, use 2-3 hours before going to bed. For patients who need to reduce symptoms further, they can increase the dose every 4-7 days to a maximum of 0.54mg of base form (3 Sifstad 0.18 tablets or 34 Sitstad 0.7)/day (as the table below). PramipExol standard schedule Salt SIFSTAD 0.7 Sitstad 0.7 * If you need to know If the treatment is interrupted for a few days, it is necessary to start the standard dose as the above table. Stop treatment Can stop using pramipexol without a slowly reduced dose due to daily dose of daily vacuum syndrome not exceeding 0.54mg of base form (3 sifstad 0.18 tablets or 34 SIFSTAD 0.7 tablets). Patients with renal failure Pramipexol elimination depends on the kidney function. Patients with creatinine clearance above 20ml/minute do not need to reduce daily dose. The use of pramipexol in patients with hemorrhage or patients with severe renal impairment has not been studied. Patients with liver failure No need to reduce the dose in patients with liver failure. Children It is recommended not to use Pramipexol for children and teenagers under 18 years of age due to lack of data on safety and efficiency. Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist. What to do when overdose? Symptoms There is no clinical experience of serious overdose. Unwanted effects that can be encountered are manifestations related to pharmacological properties of dopamine, including nausea, vomiting, hyperactivity, hallucinations, agitation and hypotension. Treatment There is no antidote for dopamine overdose. If there are signs of central nerve stimulation, sedative can be used. Overdose management by general support measures along with gastric wash, infusion, active carbon and electrocardiogram monitoring. What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Efek sisih

Nalika nggunakake SIFSTAD, sampeyan bisa ngalami efek sing ora dikarepake (ADR).

Ing pasien Parkinson

Umum, ADR> 1/100

Mental: Ngimpi abnormal, prilaku gangguan kontrol impuls lan tumindak impuls paksa, kebingungan, halusinasi, insomnia.

gemeter: sirah, pusing, gangguan gerakan, ngantuk.

Mripat: cacat sesanti, kalebu bukti, sesanti burem lan mundhut sesanti.

Pembuluh darah: Tekanan Hipotenam. pencernaan : sembelit, muntah.

Badan : Kesel, edema perifer.

Liyane: Mundhut bobot, malah nyuda napsu.

Jarang, 1/1000

Infèksi lan parasit: pneumonia.

Seneng hormon anti-hormon.

Mental: Mangan sing ora katon, blanja sing berlebihan, khayalan, mangan berlebihan, nambah aktivitas seksual, gangguan kepinginan seksual, paranoia, gambling patologis, gelisah, delirium.

Sistem saraf: Lali, hiperaktivitas, pingsan, pingsan.

Jantung: gagal jantung.

Pernafasan, dada lan mediastinum: Kesulitan ambegan, hiccups.

Kulit lan jaringan subkutan: Hipersensitivitas, gatal, ruam.

Liyane: bobot mundhut.

Langka, 1/10000

Mental: Hung Cam

Ing pasien karo akomodasi sing ora dicithak

Umum, ADR> 1/100

Mental: ngimpi abnormal, insomnia.

Sistem saraf: pusing, sirah, ngantuk.

pencernaan : sembelit, muntah. sakèhing badan: kesel.

Jarang, 1/1000

Infèksi lan parasit: pneumonia.

Seneng hormon anti-hormon.

Mental: Manifestasi saka prilaku gangguan kontrol impuls lan tumindak impulsif sing dipeksa kayata mangan sing ora bisa dirasakake, blanja sing berlebihan, aktivitas seksual sing tambah lan gambling patologis: kebingungan, ilusi, halusinasi, overeating, kelainan kepinginan seksual, paranoia, gelisah, manic, delirium.

Sistem saraf: Lali, disfungsi, hiperaktivitas, pingsan, pingsan.

Mripat: cacat sesanti, kalebu bukti, sesanti kabur lan sesanti.

Jantung: gagal jantung. Pembuluh darah: Tekanan Hipotenam.

Pernafasan, dada lan mediastinum: Kesulitan ambegan, hiccups.

Kulit lan jaringan subkutan: Hipersensitivitas, gatal, ruam.

Badan : Edema njaba.

Liyane: Mundhut bobot kalebu nyuda napsu, nambah bobot.

Petunjuk babagan cara nangani ADR

Nalika ngalami efek samping obat kasebut, sampeyan kudu mandheg nggunakake lan ngandhani dhokter utawa menyang fasilitas medis sing paling cedhak kanggo perawatan pas wektune.

Pènget

Sadurunge nggunakake obat sampeyan kudu maca instruksi kasebut kanthi teliti lan deleng informasi ing ngisor iki.

Kontraindikasi

Obat SIFSTAD dikontraindikasi ing kasus ing ngisor iki: Hipersensitivitas kanggo pramipexol utawa bahan apa wae saka obat kasebut.

Pancegahan nalika nggunakake

ilusi

Ilusi minangka efek samping Dopamin lan Levodopa sing dikenal. Pasien kudu diwenehi kabar yen khayalan bisa kedadeyan (biasane pasar virtual).

gangguan gerakan

Ing progresi penyakit Parkinson, nalika diobati kanthi kombinasi karo kelainan gerakan Levodopa bisa ditemoni nalika wiwitan nyetel dosis pramipexol. Yen kedadeyan kasebut, dosis levodopa kudu dikurangi.

Hung feeling lan delirium

Pasien kudu dipantau kanthi rutin babagan perkembangan manifestasi manik lan delirium. Pasien lan pengasuh kudu ngerti babagan Hung Cam lan delirium sing bisa kedadeyan ing pasien sing diobati karo Pramipexol. Sampeyan kudu nimbang nyuda dosis / mungkasi obat kasebut alon-alon yen gejala kasebut maju.

Priksa mripat

Perlu mriksa mripat kanthi periodik utawa yen ana penglihatan sing ora normal.

Turu lan keturon

Pramipexol ana hubungane karo rasa ngantuk lan ngantuk, utamane ing pasien Parkinson. Draying ing aktivitas saben dina sing ing sawetara kasus ora ngerti utawa ora ana pratandha saka kabar arang ditemoni. Pasien kudu dilaporake babagan iki lan ati-ati nalika nyopir utawa ngoperasikake mesin nalika diobati karo Pramipexol. Pasien sing katon ngantuk utawa turu kudu mbatesi nyopir utawa ngoperasikake mesin. Kajaba iku, perlu nimbang nyuda dosis utawa mungkasi perawatan. Amarga kemampuan kanggo duwe efek kombinasi, pasien kudu ati-ati nalika nggunakake sedative utawa alkohol (alkohol) karo pramipexol.

Gangguan kontrol nadi

Pasien kudu dipantau kanthi rutin babagan perkembangan gangguan kontrol impuls. Pasien lan pengasuh kudu ngerti gejala gangguan kontrol impuls kalebu gambling patologis, tambah libido, aktivitas seksual sing tambah, mbuwang utawa blanja sing berlebihan, akeh mangan lan mangan sing ora bener bisa kedadeyan ing pasien sing diobati karo pemilik dopamin kayata pramipexol. Sampeyan kudu nimbang nyuda dosis / mungkasi obat kasebut alon-alon yen gejala kasebut maju.

Pasien kelainan mental

Mung perawatan domapin sing didominasi kanggo pasien kelainan mental yen keuntungan luwih dhuwur tinimbang resiko. Aja nggunakake obat psikotik kanthi pramipexol bebarengan.

Penyakit jantung sing abot

Sampeyan kudu cedhak ing kasus penyakit jantung sing abot. Pemantauan tekanan getih kudu dipantau, utamane nalika miwiti perawatan, amarga risiko umum yaiku postur hipotensi sing ana gandhengane karo terapi dopaminergik.

Sindrom neuropular ganas

Munculé gejala ing sindrom neuropular ganas uga dicathet nalika dumadakan mandheg terapi dopaminergik.

Fenomena Tambah

Laporan ing literatur nuduhake yen perawatan obat dopaminergik dopaminergik bisa nyebabake sindrom kesan tambah.

Kemampuan kanggo nyopir lan ngoperasikake mesin

Pramipexol bisa mengaruhi kemampuan nyopir lan ngoperasikake mesin. Ilusi utawa turu bisa kedadeyan. Yen pasien nggunakake PramipExol, ana rasa ngantuk utawa turu, ora nyopir utawa melu kegiatan sing ilang kesadaran bisa nyebabake ciloko serius utawa pati kanggo awake dhewe utawa wong liya (kayata mesin operasi) nganti ngantuk lan ngantuk ora ana maneh.

Kandhutan

Efek ing wanita ngandhut lan lactating durung diteliti ing manungsa. PramipExol ora nyebabake teratogen ing tikus lan terwelu nanging nduweni keracunan ing embrio tikus nalika nggunakake dosis beracun kanggo tikus. PramipExol ora kena digunakake nalika meteng kajaba pancen perlu, yaiku mung perawatan yen keuntungan luwih dhuwur tinimbang risiko kanggo janin.

Periode nyusoni

Amarga pramipexol nyegah sekresi prolaktin ing manungsa, bisa nyegah sekresi susu. Ekskresi pramipexol ing susu ibu durung diteliti ing manungsa. Ing tikus, konsentrasi obat nduweni aktivitas radioaktif sing luwih dhuwur ing susu tikus tinimbang konsentrasi plasma.

Amarga ora ana data manungsa, Pramipexol ora bisa digunakake nalika nyusoni. Nanging, yen diwajibake njupuk obat kasebut, kudu mandheg nyusoni.

Interaksi obat

Amantadin: bisa nyuda reresik lisan saka PRAMIPEXOL.

cimetidine: nyebabake kenaikan 50% ing auc pramipexol lan mundhak 40% saka wektu sale (n = 12).

Obat-obatan sing diekskresi ing ginjel: Digunakake karo obat-obatan sing diekskresi dening sistem transportasi kation (contone cimetidin, ranitidin, diltiazem, triamteren, verapamil, quinidin, lan quinin) nyuda reresik oral saka PRAMIPEXOL kira-kira 20%, ing, banjur dienggo bareng karo obat-obatan sing diekskresi dening CHALPORIN, contone, sistem transportasi CEPPORIN. penisilin, indometasin, hydrodorothiazid, lan chlorpropamid) duweni pengaruh cilik marang reresik oral pramipexol.

Antagonis dopamin: Amarga pramipexol minangka pemilik dopamin, bisa uga antagonis dopamin, kayata obat penenang (phenothiazine, butyrophenones, thioxanthens) utawa metoclopramid, bisa nyuda efektifitas pramipexol.

Sampeyan kudu ngindhari panggunaan obat psikotik bebarengan karo pramipexol yen efek antagonis bisa kedadeyan.

Panyimpenan

Ing kemasan sing ditutup, panggonan sing garing. Suhu ora ngluwihi 30 ° C.

Obat liyane

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