Analgesic combinations
What are Analgesic combinations?
Analgesic combinations contain at least one analgesic in combination with another medicine or medicines. An analgesic is the name given to a medicine that relieves pain without putting you to sleep or making you lose consciousness. Analgesics may also be known as painkillers or pain relievers.
If an analgesic combination product contains two analgesics, these generally have different ways of working to relieve pain.
Analgesic combination products tend to either have acetaminophen, an NSAID (such as ibuprofen or naproxen), or an opioid (such as codeine) as one of their ingredients.
What are analgesic combinations used for?
Analgesic combinations may be taken to relieve pain that arises from a wide range of conditions, such as:
- appendicitis
- cancer
- congenital conditions such as curvature of the spine
- fibromyalgia
- gallbladder disease
- gastrointestinal disorders
- headaches
- heart disease
- improper lifting techniques or poor posture
- infection
- menstruation
- migraines
- multiple sclerosis
- nerve damage
- osteoarthritis
- pain syndromes
- poor posture
- rheumatoid arthritis
- sprains
- strains
- surgery
- trauma
- toothache
- wound cleansing and debridement.
It is important to note that not all analgesic combinations are appropriate for all these conditions.
What are the differences between the different analgesic combinations?
Analgesic combinations differ in the ingredients they contain which means there are vast differences in the way they work, their potency, (how strong they are), and in the way they are absorbed, distributed, metabolized, and excreted within the body.
Some analgesic combinations contain NSAIDs, whereas others contain opioids (narcotics). Other ingredients may include caffeine, which enhances the pain-relieving effect of an analgesic, and diphenhydramine, which is used for its sleep-inducing properties.
Analgesic combinations that contain opioids should only be used if other analgesics or analgesic combinations have proved ineffective as they are potentially addictive.
Common Analgesic combinations available in the U.S.
| Generic name | Brand name examples |
|---|---|
| acetaminophen + aspirin | Generic |
| acetaminophen + aspirin + caffeine | Arthriten, Excedrin, Goody's Extra-Strength |
| acetaminophen + butalbital | Allzital, Bupap |
| acetaminophen + butalbital + caffeine | Capacet, Fioricet |
| acetaminophen + caffeine | Excedrin Quick Tab, Excedrin Tension Headache |
| acetaminophen +caffeine + isometheptene mucate | Discontinued |
| Acetaminophen + caffeine + magnesium salicylate | Generic |
| Acetaminophen + diphenhydramine | Midol PM |
| acetaminophen + phenyltoloxamine CR | Discontinued |
| aspirin + butalbital + caffeine | Fiorinal |
| codeine + acetaminophen | Generic |
| codeine + acetaminophen + butalbital + caffeine | Fioricet with codeine |
| codeine + aspirin + butalbital + caffeine | Ascomp with codeine, Fiorinal with codeine |
| dihydrocodeine + acetaminophen + caffeine | Trezix |
| hydrocodone + acetaminophen | Generic |
| hydrocodone + ibuprofen | Generic |
| ibuprofen + diphenhydramine | Advil PM |
| naproxen + diphenhydramine | Aleve PM, Excedrin PM, Tylenol PM |
| oxycodone + acetaminophen | Nalocet, Primlev |
| tramadol + acetaminophen | Ultracet |
Are analgesic combinations safe?
Most analgesic combinations are considered safe when taken for short periods of time and exactly as directed on the packaging or by a doctor. Some analgesic combinations, such as those containing acetaminophen or ibuprofen, may be considered safer than others.
Narcotic analgesic combinations have been associated with some serious risks such as respiratory depression (unusually slow and shallow breathing), opioid-use disorder, and potentially fatal overdose. They are potentially addictive and should only be used for certain conditions and under strict monitoring.
What are the side effects of analgesic combinations?
All medicines have side effects but how vulnerable a person is to them depends on several different factors such as age, genetics, kidney function and gender (see Managing Common Drug Side Effects)
Narcotic analgesic combinations have many side effects, although people with cancer or a terminal illness taking narcotic analgesic combinations for long periods of time may become tolerant to some of these side effects.
Drowsiness, sleepiness, or dizziness are common with most narcotic analgesic combinations. These side effects may affect driving or a person's ability to operate machinery and perform other hazardous tasks. Alcohol may potentiate these effects
Combination analgesics containing NSAIDs may also cause side effects, especially when used at higher than recommended dosages for long periods of time. Gastrointestinal side effects that may occur include bloating, diarrhea, constipation, irritation of the lining of the stomach, nausea or vomiting. Combination products containing NSAIDs may also affect kidney function and reduce how quickly blood flows through the kidneys. They may cause retention of sodium and water which can lead to edema and high potassium levels. Occasionally, they may cause more serious damage to the kidneys. NSAIDs have also been associated with a higher risk of cardiovascular disease.
Combination products that contain agents that enhance sleep such as diphenhydramine may also cause drowsiness and affect a person’s ability to drive, operate machinery, or perform other hazardous tasks.
Please refer to each combination product for a full list of side effects.
List drug with Analgesic combinations
| Drug Name |
|---|
| Acetaminophen and butalbital Generic name: Acetaminophen And Butalbital |
| Acetaminophen and caffeine Generic name: Acetaminophen And Caffeine |
| Acetaminophen and diphenhydramine Generic name: Acetaminophen And Diphenhydramine |
| Acetaminophen and ibuprofen Generic name: Acetaminophen And Ibuprofen |
| Acetaminophen and phenyltoloxamine Generic name: Acetaminophen And Phenyltoloxamine |
| Acetaminophen, aspirin, and caffeine Generic name: Acetaminophen, Aspirin, And Caffeine |
| Acetaminophen, butalbital, and caffeine Generic name: Acetaminophen, Butalbital, And Caffeine |
| Acetaminophen, caffeine, and magnesium salicylate Generic name: Acetaminophen, Caffeine, And Magnesium Salicylate |
| Acetaminophen, magnesium salicylate, and pamabrom Generic name: Acetaminophen, Magnesium Salicylate, And Pamabrom |
| Acetaminophen, pamabrom, and pyrilamine Generic name: Acetaminophen, Pamabrom, And Pyrilamine |
| Acuflex Generic name: Acetaminophen And Phenyltoloxamine |
| Advil Dual Action With Acetaminophen Generic name: Acetaminophen And Ibuprofen |
| Advil PM Generic name: Diphenhydramine And Ibuprofen |
| Advil PM Liqui-Gels Generic name: Diphenhydramine And Ibuprofen |
| Aleve PM Generic name: Diphenhydramine And Naproxen |
| Alka-Seltzer Morning Relief Generic name: Aspirin And Caffeine |
| Allzital Generic name: Acetaminophen And Butalbital |
| Anacin Generic name: Aspirin And Caffeine |
| Anacin Advanced Headache Formula Generic name: Acetaminophen, Aspirin, And Caffeine |
| Anacin Extra Strength Generic name: Aspirin And Caffeine |
| Anolor 300 Generic name: Butalbital, Acetaminophen, And Caffeine |
| Arthriten Generic name: Acetaminophen, Aspirin, And Caffeine |
| Aspirin and caffeine Generic name: Aspirin And Caffeine |
| Aspirin, butalbital, and caffeine Generic name: Aspirin, Butalbital, And Caffeine |
| Combogesic Generic name: Acetaminophen And Ibuprofen |
| Combogesic (Acetaminophen/ibuprofen Oral) Generic name: Acetaminophen/ibuprofen |
| Combogesic (Ibuprofen and acetaminophen Oral) Generic name: Ibuprofen And Acetaminophen |
| Cope Generic name: Aspirin And Caffeine |
| Backaid IPF Generic name: Acetaminophen, Aspirin, And Caffeine |
| Bayer Back and Body Generic name: Aspirin And Caffeine |
| BC Generic name: Aspirin And Caffeine |
| BC Arthritis Generic name: Aspirin And Caffeine |
| Bupap Generic name: Acetaminophen And Butalbital |
| Bupivacaine and meloxicam Generic name: Bupivacaine And Meloxicam |
| Butalbital and acetaminophen Generic name: Butalbital And Acetaminophen |
| Butalbital, acetaminophen, and caffeine Generic name: Butalbital, Acetaminophen, And Caffeine |
| Butalbital, aspirin, and caffeine Generic name: Butalbital, Aspirin, And Caffeine |
| Cephadyn Generic name: Butalbital And Acetaminophen |
| Diphenhydramine and ibuprofen Generic name: Diphenhydramine And Ibuprofen |
| Diphenhydramine and magnesium salicylate Generic name: Diphenhydramine And Magnesium Salicylate |
| Diphenhydramine and naproxen Generic name: Diphenhydramine And Naproxen |
| Doans PM Generic name: Diphenhydramine And Magnesium Salicylate |
| Dolgic LQ Generic name: Butalbital, Acetaminophen, And Caffeine |
| Dologesic Generic name: Acetaminophen And Phenyltoloxamine |
| Dologesic DF Generic name: Acetaminophen And Phenyltoloxamine |
| Esgic Generic name: Acetaminophen, Butalbital, And Caffeine |
| Esgic-Plus Generic name: Butalbital, Acetaminophen, And Caffeine |
| Excedrin Generic name: Acetaminophen, Aspirin, And Caffeine |
| Excedrin Migraine Generic name: Acetaminophen, Aspirin, And Caffeine |
| Excedrin Quick Tab Peppermint Generic name: Acetaminophen And Caffeine |
| Excedrin Quick Tab Spearmint Generic name: Acetaminophen And Caffeine |
| Excedrin Tension Headache Generic name: Acetaminophen And Caffeine |
| Excedrin Tension Headache Caplet Generic name: Acetaminophen And Caffeine |
| Excedrin Tension Headache Express Gels Generic name: Acetaminophen And Caffeine |
| Excedrin Tension Headache Geltab Generic name: Acetaminophen And Caffeine |
| Ezol Generic name: Butalbital, Acetaminophen, And Caffeine |
| Fioricet Generic name: Acetaminophen, Butalbital, And Caffeine |
| Fiorinal Generic name: Aspirin, Butalbital, And Caffeine |
| Flextra Generic name: Acetaminophen, Caffeine, And Phenyltoloxamine |
| Fortabs Generic name: Butalbital, Aspirin, And Caffeine |
| Genace Generic name: Acetaminophen, Aspirin, And Caffeine |
| Geone Generic name: Butalbital, Acetaminophen, And Caffeine |
| Goody's Headache Powders Generic name: Acetaminophen, Aspirin, And Caffeine |
| Goodys Extra Strength Generic name: Acetaminophen, Aspirin, And Caffeine |
| Headache Relief PM Generic name: Acetaminophen And Diphenhydramine |
| Ibuprofen and acetaminophen Generic name: Ibuprofen And Acetaminophen |
| Ibuprofen PM Generic name: Diphenhydramine And Ibuprofen |
| Laniroif Generic name: Butalbital, Aspirin, And Caffeine |
| Legatrin PM Generic name: Acetaminophen And Diphenhydramine |
| Margesic Generic name: Butalbital, Acetaminophen, And Caffeine |
| Medigesic Generic name: Butalbital, Acetaminophen, And Caffeine |
| Midol PM Generic name: Acetaminophen And Diphenhydramine |
| Midol PMS Maximum Strength Generic name: Acetaminophen, Pamabrom, And Pyrilamine |
| MigraTen Generic name: Acetaminophen, Caffeine, And Isometheptene |
| Motrin PM Generic name: Diphenhydramine And Ibuprofen |
| Nonbac Generic name: Butalbital, Acetaminophen, And Caffeine |
| Orbivan CF Generic name: Butalbital And Acetaminophen |
| P-A-C Analgesic Generic name: Aspirin And Caffeine |
| Pacaps Generic name: Butalbital, Acetaminophen, And Caffeine |
| Pain Reliever Plus Generic name: Acetaminophen, Aspirin, And Caffeine |
| Pamprin Cramp Formula Generic name: Acetaminophen, Magnesium Salicylate, And Pamabrom |
| Pamprin Multi-Symptom Generic name: Acetaminophen, Pamabrom, And Pyrilamine |
| Percogesic Extra Strength Generic name: Acetaminophen And Diphenhydramine |
| Percogesic Original Strength Generic name: Acetaminophen And Diphenhydramine |
| Phrenilin Generic name: Butalbital And Acetaminophen |
| Phrenilin Forte Generic name: Butalbital And Acetaminophen |
| Premesyn PMS Generic name: Acetaminophen, Pamabrom, And Pyrilamine |
| Repan Generic name: Butalbital, Acetaminophen, And Caffeine |
| Stanback Generic name: Aspirin And Caffeine |
| Tylenol PM Generic name: Acetaminophen And Diphenhydramine |
| Zebutal Generic name: Acetaminophen, Butalbital, And Caffeine |
| Zynrelef Generic name: Bupivacaine And Meloxicam |
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