BCR-ABL tyrosine kinase inhibitors

What are BCR-ABL tyrosine kinase inhibitors?

BCR-ABL tyrosine kinase inhibitors inhibit the enzyme BCR-ABL tyrosine kinase, which is important in the pathogenesis of chronic myelogenous leukemia (CML).

Chronic myelogenous leukemia occurs due a single genetic abnormality, known as the Philadelphia chromosome. During the translocation when the Philadelphia chromosome is created, a fusion gene called BCR-ABL gene is formed. The BCR-ABL gene encodes for the BCR-ABL tyrosine kinase. The BCR-ABL positive cells in chronic myelogenous leukemia have increased proliferation and resistance to cell death.

BCR-ABL tyrosine kinase inhibitors are used to treat chronic myelogenous leukemia.

List drug with BCR-ABL tyrosine kinase inhibitors

Drug Name
Asciminib
Generic name: Asciminib
Bosulif
Generic name: Bosutinib
Bosutinib
Generic name: Bosutinib
Dasatinib
Generic name: Dasatinib
Gleevec
Generic name: Imatinib
Imatinib
Generic name: Imatinib
Nilotinib
Generic name: Nilotinib
Scemblix
Generic name: Asciminib
Sprycel
Generic name: Dasatinib
Tasigna
Generic name: Nilotinib

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