Hedgehog pathway inhibitors

What are Hedgehog pathway inhibitors?

The Hedgehog pathway plays an essential role in cell growth and differentiation in the developing embryo. It is typically silenced in adult tissues. In postembryonic life, the pathway may be activated to stimulate tissue repair or cell proliferation. Abnormal activation may lead to cancer, including basal cell carcinoma. Hedgehog pathway inhibitors target the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors. Hedgehog pathway inhibitors may be used to treat basal cell carcinoma that has spread to other parts of the body.

List drug with Hedgehog pathway inhibitors

Drug Name
Daurismo
Generic name: Glasdegib
Erivedge
Generic name: Vismodegib
Glasdegib
Generic name: Glasdegib
Odomzo
Generic name: Sonidegib
Sonidegib
Generic name: Sonidegib
Vismodegib
Generic name: Vismodegib

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