HER2 inhibitors

What are HER2 inhibitors?

Human epidermal growth factor receptor (HER2) inhibitors are either tyrosine kinase inhibitors or monoclonal antibodies that slow down or stop cell growth.

Human epidermal growth factor receptors are transmembrane receptors; they have an extracellular binding component, a transmembrane component and an intracellular tyrosine kinase component. Some breast cancers have an over-expression of HER2 resulting in increased cell growth and spread of cancer cells.

Tyrosine kinase inhibitors bind to the tyrosine kinase domain in the HER2 and stops activation of the signaling pathway. Monoclonal antibodies bind to the extracellular component of the HER2, prevent the actual substrates from binding to the receptors and stop the receptor activation.

HER2 inhibitors are used in the treatment of breast cancer.

List drug with HER2 inhibitors

Drug Name
Ado-trastuzumab emtansine
Generic name: Ado-trastuzumab Emtansine
Enhertu
Generic name: Fam-trastuzumab Deruxtecan
Fam-trastuzumab deruxtecan
Generic name: Fam-trastuzumab Deruxtecan
Fam-trastuzumab deruxtecan-nxki
Generic name: Fam-trastuzumab Deruxtecan-nxki
Herceptin
Generic name: Trastuzumab
Herceptin Hylecta
Generic name: Trastuzumab And Hyaluronidase-oysk
Herzuma
Generic name: Trastuzumab
Herzuma (Trastuzumab Intravenous)
Generic name: Trastuzumab
Herzuma (Trastuzumab-pkrb Intravenous)
Generic name: Trastuzumab-pkrb
Hyaluronidase and trastuzumab
Generic name: Hyaluronidase And Trastuzumab
Hyaluronidase, pertuzumab, and trastuzumab
Generic name: Hyaluronidase, Pertuzumab, And Trastuzumab
Kadcyla
Generic name: Ado-trastuzumab Emtansine
Margenza
Generic name: Margetuximab
Margetuximab
Generic name: Margetuximab
Margetuximab-cmkb
Generic name: Margetuximab-cmkb
Ogivri
Generic name: Trastuzumab
Ogivri (Trastuzumab Intravenous)
Generic name: Trastuzumab
Ogivri (Trastuzumab-dkst Intravenous)
Generic name: Trastuzumab-dkst
Ontruzant
Generic name: Trastuzumab
Ontruzant (Trastuzumab Intravenous)
Generic name: Trastuzumab
Ontruzant (Trastuzumab-dttb Intravenous)
Generic name: Trastuzumab-dttb
Perjeta
Generic name: Pertuzumab
Pertuzumab
Generic name: Pertuzumab
Pertuzumab, trastuzumab, and hyaluronidase-zzxf
Generic name: Pertuzumab, Trastuzumab, And Hyaluronidase-zzxf
Phesgo
Generic name: Hyaluronidase, Pertuzumab, And Trastuzumab
Trastuzumab
Generic name: Trastuzumab
Trastuzumab and hyaluronidase-oysk
Generic name: Trastuzumab And Hyaluronidase-oysk
Trastuzumab-anns
Generic name: Trastuzumab-anns
Trastuzumab-dkst
Generic name: Trastuzumab-dkst
Trastuzumab-dttb
Generic name: Trastuzumab-dttb
Trastuzumab-pkrb
Generic name: Trastuzumab-pkrb
Trazimera
Generic name: Trastuzumab-qyyp
Tucatinib
Generic name: Tucatinib
Tukysa
Generic name: Tucatinib

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