Hereditary angioedema agents

What are Hereditary angioedema agents?

Hereditary angioedema (HAE) agents treat and/or prevent HAE attacks. HAE is a rare genetic condition that occurs in people with low levels of a certain protein in their bodies called C1-INH (C1 esterase inhibitor); or in some cases, nonfunctional C1-INH. C1-INH helps regulate several cascade systems within our body, such as the complement system, the intrinsic coagulation system and the coagulation cascade (the process that causes our blood to clot), and the fibrinolytic system (the process that removes and degrades clots after blood vessels are repaired). It also helps control bradykinin production (bradykinin is a protein fragment that increases the movement of fluid through blood vessel walls, resulting in swelling and inflammation).

During an attack, levels of C1-INH become so low that angioedema (severe swelling in the limbs, face, intestinal tract, and airway) occurs. HAE agents that treat or prevent HAE attacks add working C1-INH to the plasma, which brings levels of C1 back up and closer to normal, reducing bradykinin production, decreasing the permeability of blood vessels, and reducing swelling.

 

List drug with Hereditary angioedema agents

Drug Name
Complement C1 esterase inhibitor
Generic name: Complement C1 Esterase Inhibitor
Conestat alfa
Generic name: Conestat Alfa
C1 esterase inhibitor recombinant
Generic name: C1 Esterase Inhibitor Recombinant
C1 esterase inhibitor, human
Generic name: C1 Esterase Inhibitor, Human
Berinert
Generic name: Complement C1 Esterase Inhibitor
Berotralstat
Generic name: Berotralstat
Cinryze
Generic name: Complement C1 Esterase Inhibitor
Ecallantide
Generic name: Ecallantide
Firazyr
Generic name: Icatibant
Haegarda
Generic name: C1 Esterase Inhibitor Subcutaneous (human)
Icatibant
Generic name: Icatibant
kalbitor
Generic name: Ecallantide
Lanadelumab
Generic name: Lanadelumab
Lanadelumab-flyo
Generic name: Lanadelumab-flyo
Orladeyo
Generic name: Berotralstat
Ruconest
Generic name: C1 Esterase Inhibitor Recombinant Injection (conestat Alfa)
Takhzyro
Generic name: Lanadelumab-flyo

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