Histone deacetylase inhibitors

What are Histone deacetylase inhibitors?

Histone deacetylase (HDAC) inhibitors are a group of agents that inhibit the histone deactylase enzymes. During gene expression DNA coils and uncoils around histones. Histone acetylases, acetylate the lysine residues in core histones and histone deactylases remove the acetyl groups from the lysine residues. These actions are important in the regulation of gene expression.

Histone deacetylase inhibitors prevent the deactylation, affect gene expression and causes apoptosis of tumor cells. Histone deacetylase inhibitors are used to treat cutaneous T-cell lymphoma.

List drug with Histone deacetylase inhibitors

Drug Name
Beleodaq
Generic name: Belinostat
Belinostat
Generic name: Belinostat
Farydak
Generic name: Panobinostat
Istodax
Generic name: Romidepsin
Panobinostat
Generic name: Panobinostat
Romidepsin
Generic name: Romidepsin
Vorinostat
Generic name: Vorinostat
Zolinza
Generic name: Vorinostat

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