NHE3 inhibitors

What are NHE3 Inhibitors?

NHE3 Inhibitors are a class of medicine that works by inhibiting the Sodium-Proton-Exchanger subtype 3 (NHE3) in the gut. They may be used to treat constipation associated with irritable bowel syndrome with constipation.

NHE3 mediates the exchange of sodium, and sodium is an essential electrolyte in our body that helps maintain water balance, influences blood pressure, and is important for proper muscle and nerve function. High intestinal sodium absorption is one cause of high blood pressure (hypertension).

Medicines that inhibit NHE3 have been shown to reduce high blood pressure and increase the excretion of sodium in the feces, which can soften hard feces, relieving constipation. An improvement is also seen in the functioning of the left ventricle in the heart, but this does not seem to have an effect on the increase and growth of muscle cells (hypertrophy) that ultimately lead to heart enlargement.

What are NHE3 Inhibitors used for?

NHE3 inhibitors may be used for the treatment of irritable bowel syndrome with constipation (IBS-C) in adults.

What are the Side Effects of NHE3 inhibitors?

Side effects of NHE3 inhibitors include dehydration (which can be serious in the old or the young), diarrhea, bloating, flatulence, abnormal bowel sounds, low blood pressure, and dizziness.

Are there any Interactions with NHE3 Inhibitors?

There are no known interactions with NHE3 inhibitors.

List drug with NHE3 inhibitors

Drug Name
Ibsrela Generic name: Tenapanor
Tenapanor Generic name: Tenapanor
Xphozah Generic name: Tenapanor

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.