Skeletal muscle relaxants
What are Skeletal muscle relaxants?
Skeletal muscle relaxants are drugs that are used to relax and reduce tension in muscles. They are more simply referred to as muscle relaxants.
Some work in the brain or spinal cord to block or dampen down excessively stimulated nerve pathways. These are called centrally acting muscle relaxants and examples include baclofen, methocarbamol, and tizanidine.
Others act directly on muscle fibers and are classified as peripherally acting muscle relaxants. Examples include dantrolene and the different types of botulinum toxin. Although dantrolene acts directly on the muscle itself, it also appears to indirectly act on the central nervous system and can cause drowsiness.
Cannabis extract also has muscle relaxing properties and is thought to act both centrally and peripherally.
What are skeletal muscle relaxants used for?
Skeletal muscle relaxants are mainly used to treat:
- spasticity, which is another term for stiff and rigid muscles caused by conditions such as cerebral palsy, multiple sclerosis, or stroke
- muscle spasms which are temporary muscular contractions that are often associated conditions such as tension headache, low back pain, or fibromyalgia
- cervical dystonia - a painful condition where the neck muscles involuntarily contract, causing your head to uncontrollably tilt forward or backward.
What are the differences between skeletal muscle relaxants?
Skeletal muscle relaxants differ in the way they work (centrally or peripherally as discussed above), their side effects, and their effectiveness for certain conditions.
Note that several other medicines, notably diazepam, may also be used as a muscle relaxant and are not listed below.
| Generic name | Brand name | FDA approval (spasm-related) |
|---|---|---|
| abobotulinumtoxinA | Dysport | Cervical dystonia, Muscle spasms |
| baclofen | Gablofen, Lioresal | General spasticity |
| carisoprodol | Soma | Muscle spasms |
| chlorzoxazone | Generic | Muscle spasms |
| cyclobenzaprine | Amrix | Muscle spasms |
| daxibotulinumtoxinA | Daxxify | Glabellar lines |
| dantrolene | Dantrium | General spasticity |
| onabotulinumtoxinA | Botox | Cervical dystonia, Muscle spasms |
| orphenadrine | Generic | Muscle spasms |
| metaxalone | Skelaxin | Muscle spasms |
| methocarbamol | Robaxin | Muscle spasms |
| rimabotulinumtoxinB | Mybloc | Cervical dystonia |
| tizanidine | Zanaflex | General spasticity |
Are skeletal muscle relaxants safe?
Evidence supporting the effectiveness of skeletal muscle relaxants for muscle spasm is sparse; most trials are old and not of good quality. Skeletal muscle relaxants consist of a varied range of medicines and some may not be suitable for people with certain medical conditions such as an enlarged prostate, epilepsy, glaucoma, intestinal problems, liver or kidney disease, or myasthenia gravis. Many also interact with other medications.
Some, like dantrolene, can adversely affect the liver and blood samples should be taken before treatment to check for any pre-existing liver disease or to establish how well the liver is functioning before treatment, and what effect the drug subsequently has.
Muscle relaxants can affect overall muscle tone and may be dangerous if muscle tone is needed for safe balance or movement. Alcohol can enhance these effects. Many muscle relaxants need to be tapered off slowly, rather than abruptly stopped.
What are the side effects of skeletal muscle relaxants?
Drowsiness is common, particularly with centrally acting muscle relaxants; however, drowsiness can occur with some peripherally acting muscle relaxants, such as dantrolene, as well. This may impair the ability of a person to drive or operate machinery or perform hazardous tasks.
Some may also cause side effects such as a dry mouth, fast heartbeat, gastrointestinal upset (such as nausea, vomiting, constipation), headache, insomnia, light headedness, problems with urination, and other unwanted effects.
Products containing botulinum toxin may cause generalized muscle weakness, vision changes, breathing difficulties and other serious side effects if the toxin spreads from the area of injection.
List drug with Skeletal muscle relaxants
| Drug Name |
|---|
| Baclofen Generic name: Baclofen (oral) |
| Baclofen (Intrathecal) Generic name: Baclofen |
| Baclofen (Oral) Generic name: Baclofen |
| Botox Generic name: OnabotulinumtoxinA |
| Botox Cosmetic Generic name: OnabotulinumtoxinA (Botox) |
| Carisoprodol Generic name: Carisoprodol |
| Chlorzoxazone Generic name: Chlorzoxazone |
| Dantrium Generic name: Dantrolene |
| Dantrium Intravenous Generic name: Dantrolene |
| Dantrolene Generic name: Dantrolene (oral) |
| Dantrolene (Intravenous) Generic name: Dantrolene |
| Dantrolene (Oral) Generic name: Dantrolene |
| DaxibotulinumtoxinA Generic name: DaxibotulinumtoxinA (Daxxify) |
| Daxibotulinumtoxina-lanm Generic name: Daxibotulinumtoxina-lanm |
| Daxxify Generic name: DaxibotulinumtoxinA-lanm |
| Dysport Generic name: AbobotulinumtoxinA |
| Fexmid Generic name: Cyclobenzaprine |
| FIRST Baclofen Generic name: Baclofen (oral) |
| Fleqsuvy Generic name: Baclofen (oral) |
| Flexeril Generic name: Cyclobenzaprine |
| FusePaq Tabradol Generic name: Cyclobenzaprine |
| Gablofen Generic name: Baclofen |
| IncobotulinumtoxinA Generic name: IncobotulinumtoxinA |
| Jeuveau Generic name: PrabotulinumtoxinA |
| Lioresal Generic name: Baclofen |
| Lorzone Generic name: Chlorzoxazone |
| Lyvispah Generic name: Baclofen (oral) |
| Metaxalone Generic name: Metaxalone |
| Methocarbamol Generic name: Methocarbamol (oral/injection) |
| Methocarbamol (Injection) Generic name: Methocarbamol |
| Methocarbamol (Oral) Generic name: Methocarbamol |
| Mio-Rel Generic name: Orphenadrine |
| Norflex Generic name: Orphenadrine |
| Norflex (Orphenadrine Injection) Generic name: Orphenadrine |
| Norflex (Orphenadrine Oral) Generic name: Orphenadrine |
| OnabotulinumtoxinA Generic name: OnabotulinumtoxinA (Botox) |
| Orfro Generic name: Orphenadrine |
| Orphenadrine Generic name: Orphenadrine |
| Orphenadrine (Injection) Generic name: Orphenadrine |
| Orphenadrine (Oral) Generic name: Orphenadrine |
| Orphenate Generic name: Orphenadrine |
| Ozobax Generic name: Baclofen (oral) |
| Paraflex Generic name: Chlorzoxazone |
| Parafon Forte DSC Generic name: Chlorzoxazone |
| PrabotulinumtoxinA Generic name: PrabotulinumtoxinA |
| Prabotulinumtoxina-xvfs Generic name: Prabotulinumtoxina-xvfs |
| Remular-S Generic name: Chlorzoxazone |
| Revonto Generic name: Dantrolene |
| RimabotulinumtoxinB Generic name: RimabotulinumtoxinB (Myobloc) |
| Robaxin Generic name: Methocarbamol |
| Robaxin (Methocarbamol Injection) Generic name: Methocarbamol |
| Robaxin (Methocarbamol Oral) Generic name: Methocarbamol |
| Robaxin-750 Generic name: Methocarbamol (oral/injection) |
| Ryanodex Generic name: Dantrolene |
| Skelaxin Generic name: Metaxalone |
| Soma Generic name: Carisoprodol |
| Tizanidine Generic name: Tizanidine |
| Vanadom Generic name: Carisoprodol |
| Xeomin Generic name: IncobotulinumtoxinA |
| Zanaflex Generic name: Tizanidine |
| Zanaflex Capsule Generic name: Tizanidine |
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Popular Keywords
- metformin obat apa
- alahan panjang
- glimepiride obat apa
- takikardia adalah
- erau ernie
- pradiabetes
- besar88
- atrofi adalah
- kutu anjing
- trakeostomi
- penginapan di alahan panjang
- nutrition faktory
- doksisiklin
- waist adalah
- kolonoskopi adalah
- obat glimepiride
- antiemetik adalah
- efek samping metformin
- sudut 45 derajat
- plasebo adalah
- mayzent pi
- enbrel auto injector not working
- enbrel interactions
- lenvima life expectancy
- leqvio pi
- what is lenvima
- lenvima pi
- empagliflozin-linagliptin
- encourage foundation for enbrel
- qulipta drug interactions
- qulipta side effects anxiety
- repotrectinib side effects
- ibrance para que sirve
- foods to avoid while taking enbrel
- 反応 速度 鍛える
- baby shampoo eczema
- cdk inhibitor breast cancer
- xulane package insert
- loryna side effects
- keytruda pi
- estarylla vs sprintec
- pros and cons of junel birth control
- tissue plasminogen activator
- jolessa
- ワセリン ベビー パウダー
- tintes para piel morena
- parp 阻害 薬
- デスモイド
- erau ernie
- vasoplex side effects
- rutina de hombros
- merk pre workout
- 湾曲ペニス
- best work out shoes
- ウィニペグ大学
- transparent labs creatine hmb
- nutrition faktory
- メトホルミン 効果発現
- お 風呂 おもちゃ 赤ちゃん
- メトホルミン 副作用