Thrombolytics

What are Thrombolytics?

Thrombolytics are medicines that may be used for the emergency treatment of an ischemic stroke (a stroke caused by a blood clot), a heart attack (myocardial infarction), or a massive pulmonary embolism (PE). They may also be used for other indications.

Thrombolytics break up clots by activating fibrinolysis and converting plasminogen to plasmin which lyses the clot. This allows blood and oxygen to reperfuse the area, limiting tissue damage. Thrombolytics are more effective if initiated as soon as possible after the event (such as a heart attack, stroke, or PE) but can be given within three hours of symptom onset for a stroke, or within 12-24 hours of symptom onset for a heart attack.

Major bleeding, including bleeding into the brain, is the most common risk associated with thrombolytics.

List drug with Thrombolytics

Drug Name
Activase
Generic name: Alteplase
Alteplase
Generic name: Alteplase
Alteplase, recombinant
Generic name: Alteplase, Recombinant
Abbokinase
Generic name: Urokinase
Cathflo Activase
Generic name: Alteplase
Kinlytic
Generic name: Urokinase
Retavase
Generic name: Reteplase
Reteplase
Generic name: Reteplase
Reteplase, recombinant
Generic name: Reteplase, Recombinant
Streptase
Generic name: Streptokinase
Streptokinase
Generic name: Streptokinase
Tenecteplase
Generic name: Tenecteplase
TNKase
Generic name: Tenecteplase
Urokinase
Generic name: Urokinase

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