Abilify Asimtufii

Generic name: Aripiprazole
Dosage form: extended-release injectable suspension, for intramuscular use

Usage of Abilify Asimtufii

Abilify Asimtufii is an atypical antipsychotic used for schizophrenia and bipolar I disorder in adults, Abilify Asimtufii is an extended-release injection that is given once every two months.

The exact way in which Abilify Asimtufii works (mechanism of action) to treat schizophrenia and bipolar I disorder is not known, but it is thought to work by balancing the levels of serotonin and dopamine in the brain.

Abilify (aripiprazole) is also available as Abilify (oral tablets), Abilify MyCite (tablet embedded with an ingestible sensor), and Abilify Maintena (extended-release injection for administration once every month).

Abilify Asimtufii is a longer-acting slow-release injection that is given every two months, this helps compliance and means patients only need 6 injections per year.

Abilify Asimtufii side effects

Get emergency medical help if you have signs of an allergic reaction to aripiprazole: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor right away if you have new or sudden changes in mood or behavior, including new or worse depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, more active or talkative, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

severe agitation, distress, or restless feeling;

twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;

mask-like appearance of the face, trouble swallowing, problems with speech;

seizure (convulsions);

severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;

low blood cell counts - fever, chills, sore throat, weakness, easy bruising, unusual bleeding, purple or red spots under your skin; or

high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.

Common Abilify Asimtufii side effects may include:

blurred vision;

increased saliva or drooling;

muscle stiffness;

uncontrolled muscle movements, shaking, anxiety, feeling restless;

weight gain;

nausea, vomiting, constipation;

increased or decreased appetite;

headache, dizziness, drowsiness, feeling tired;

sleep problems (insomnia); or

cold symptoms such as stuffy nose, sneezing, sore throat;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Abilify Asimtufii

You should not take this medicine if you are allergic to the active ingredient aripiprazole or any of the inactive ingredients. This medicine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

To make sure Abilify Asimtufii is safe for you, tell your doctor if you have:

heart problems or a stroke;

high or low blood pressure;

diabetes (in you or a family member);

seizures; or

low white blood cell (WBC) counts.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

This medicine can cause high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels carefully.

Pregnancy

Tell your healthcare provider if you are pregnant or plan to become pregnant. This medicine may harm your unborn baby. Receiving this medicine during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. Talk to your healthcare provider about the risk to your unborn baby if you receive this medicine during pregnancy. Do not stop the medicine without your doctor's advice.

Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment. If you become pregnant during treatment, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics. You can register by calling 1-866-961-2388 or visit http://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/.

Breastfeeding

Tell your healthcare provider if you are breastfeeding or plan to breastfeed. This medicine can pass into your breast milk, and it is not known if it may harm your baby. Talk to your healthcare provider about the best way to feed your baby during treatment.

How to use Abilify Asimtufii

Usual Abilify Asimtufii Adult Dose for Schizophrenia

Dose: 960 mg administered once every 2 months as a single injection.

Use: for the treatment of schizophrenia in adults.

Comments:

Dose can be reduced to 720 mg in patients with adverse reactions.

For patients naïve to aripiprazole, establish tolerability with oral aripiprazole prior to initiating treatment.

Administer by intramuscular injection in the gluteal muscle by a healthcare professional.

Do not administer by any other route.

Usual Abilify Asimtufii Adult Dose for Bipolar I Disorder

Dose: 960 mg administered once every 2 months as a single injection.

Use: maintenance monotherapy treatment of bipolar I disorder in adults.

Comments:

Dose can be reduced to 720 mg in patients with adverse reactions.

For patients naïve to aripiprazole, establish tolerability with oral aripiprazole prior to initiating treatment.

Administer by intramuscular injection in the gluteal muscle by a healthcare professional. Do not administer by any other route.

Warnings

Abilify Asimtufii is not approved for use in older adults with dementia-related psychosis.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting medicine to treat depression. Tell your doctor right away if you have any sudden changes in mood or behavior or thoughts about suicide.

Do not stop using aripiprazole suddenly, or you could have unpleasant withdrawal symptoms.

Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how aripiprazole affects you.

High blood sugar or diabetes, high cholesterol, and weight gain have happened with drugs like this one. These may raise the chance of heart and brain blood vessel disease.

Low white blood cell counts have happened with drugs like this one. This may lead to a higher chance of infection. Rarely, infections have been deadly. Tell your doctor if you have ever had a low white blood cell count. Call your doctor right away if you have signs of infection like fever, chills, or sore throat.

What other drugs will affect Abilify Asimtufii

Tell your healthcare provider about all the medicines you take, including prescription medicines and over-the-counter medicines, vitamins, and herbal supplements.

Abilify Asimtufii and other medicines may affect each other causing possible serious side effects. This injection may affect the way other medicines work, and vice versa.

Your healthcare provider can tell you if it is safe to receive this injection with your other medicines. Do not start or stop any medicines during treatment without first talking to your healthcare provider.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

Especially tell your healthcare provider if you take any of the following medicines:

clarithromycin (Biaxin)

antidepressants such as fluoxetine (Prozac), paroxetine (Paxil), and nefazodone

antifungals such as fluconazole (Diflucan), ketoconazole (Nizoral), and itraconazole (Sporanox)

quinidine

HIV medicines such as indinavir (Crixivan), ritonavir (Norvir), saquinavir (Fortova, Invirase), and lopinavir/ritonavir (Kaletra)

carbamazepine (Tegretol)

rifampin (Rifadin).

To check for interactions with Abilify Asimtufii, click on the link below.

Popular FAQ

Aripiprazole is one of those medications that can cause sleepiness in some people and insomnia (an inability to get to sleep) in others. Aripiprazole should be preferably taken in the morning, especially if it keeps you awake at night. Research also suggests taking it at night may antagonize D2 dopamine receptors and disrupt 24h rhythms in insulin release, possibly exacerbating metabolic dysfunction. Continue reading

Although Abilify (aripiprazole) has been found to cause less weight gain than other atypical antipsychotics, there is evidence that in certain people it can cause significant weight gain and it may be more likely to cause weight gain in people who are taking it for depression alongside other antidepressants. Side effects such as weight gain may be significant enough for some people to discontinue Abilify, even when it is working well to manage symptoms. Continue reading

Abilify (aripiprazole) and Vraylar (cariprazine) are both classified as atypical antipsychotic medications. They help treat mental health conditions such as schizophrenia, bipolar disorder (also known as manic-depression) and as additive treatment for major depressive disorder. These medicines work by changing the actions of chemicals in the brain to help stabilize your thoughts, actions and moods. Continue reading

The main differences between Abilify and Abilify Maintena are how they are supplied, how they are administered, their FDA-approved uses and their costs. They both contain the active ingredient aripiprazole, an atypical antipsychotic, and are approved for the treatment of schizophrenia and bipolar disorder. Continue reading

The oral tablet formulation Abilify MyCite (aripiprazole) is embedded with the ingestible Proteus sensor that allows patients, and, if given access, doctors and caregivers, to track ingestion of the Abilify medication on a smartphone or web-based portal. The system sends a message from the pill’s sensor to a wearable patch on the patient, which then transmits to the device. Continue reading

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