Acalabrutinib

Generic name: Acalabrutinib
Brand names: Calquence
Dosage form: oral tablet (100 mg)
Drug class: BTK inhibitors

Usage of Acalabrutinib

Acalabrutinib is used to treat mantle cell lymphoma in adults who have received at least one prior treatment for this condition.

Acalabrutinib is also used to treat adults with chronic lymphocytic leukemia or small lymphocytic lymphoma.

Acalabrutinib may also be used for purposes not listed in this medication guide.

Acalabrutinib side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Acalabrutinib may cause a brain infection that can lead to disability or death. Tell your doctor if you have problems with speech, thought, vision, or muscle movement. These symptoms can get worse quickly.

Acalabrutinib may cause serious side effects. Call your doctor at once if you have:

unusual bleeding--nosebleeds, bleeding gums, abnormal vaginal bleeding, any bleeding that will not stop;

bleeding inside your body--weakness, dizziness, confusion; problems with speech, prolonged headache, bloody or tarry stools, pink or brown urine; coughing up blood or vomit that looks like coffee grounds;

heart rhythm disorders--dizziness, chest pain, shortness of breath, fast or irregular heart rate, feeling light-headed;

low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or

signs of infection--fever, chills, tiredness, flu-like symptoms, cough with mucus, chest pain, trouble breathing.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of acalabrutinib may include:

bruising;

headache, feeling tired;

muscle or joint pain;

low blood cell counts;

diarrhea; or

cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Acalabrutinib

Tell your doctor if you have or have ever had:

an active or chronic infection, including hepatitis B;

a heart rhythm disorder;

bleeding problems;

recent surgery or plan to have surgery, medical or dental procedure; or

liver disease.

Taking acalabrutinib may increase your risk of developing other cancers. Ask your doctor about this risk.

You may need to have a negative pregnancy test before starting this treatment.

May cause birth defects. Do not use if you are pregnant. You must use effective birth control while using acalabrutinib and for at least 1 week after your last dose. Tell your doctor if you become pregnant.

Do not breastfeed while using acalabrutinib, and for at least 2 weeks after your last dose.

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How to use Acalabrutinib

Usual Adult Dose for Lymphoma:

100 mg orally every 12 hours Comments: -Start treatment at cycle 1 (each cycle is 28 days) when use concomitantly with obinutuzumab. -Start obinutuzumab at Cycle 2 for a total of 6 cycles and refer to the obinutuzumab prescribing information for recommended dosing; administer this drug prior to obinutuzumab when given on the same day.-Treatment should be continued until disease progression or unacceptable toxicity.Use:-As monotherapy for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy-As monotherapy or in combination with obinutuzumab for the treatment of adult patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)

Warnings

You may get infections or bleed more easily. Call your doctor if you have unusual bleeding or signs of infection (fever, cough, skin sores, painful urination).

What other drugs will affect Acalabrutinib

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

If you use a stomach acid reducer such as cimetidine, ranitidine, Tagamet, Pepcid, or Zantac, take acalabrutinib dose 2 hours before taking any of these other medicines.

Tell your doctor about all your current medicines. Many drugs can affect acalabrutinib, especially:

a blood thinner (warfarin, Coumadin, Jantoven);

an antibiotic or antifungal medicine (itraconazole, fluconazole, erythromycin, rifampin);

antiviral medicine to treat hepatitis C or HIV/AIDS;

heart medication (diltiazem) ; or

a proton pump inhibitor stomach acid medicine--such as omeprazole, lansoprazole, rabeprazole, Nexium, Prevacid, Prilosec, Protonix, and others.

This list is not complete and many other drugs may affect acalabrutinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

A 2021 phase III study in the Journal of Clinical Oncology found that while both medications have similar efficacy, acalabrutinib was better tolerated with fewer side effects. Continue reading

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