Acetaminophen, dextromethorphan, and diphenhydramine

Generic name: Acetaminophen, Dextromethorphan, And Diphenhydramine
Dosage form: oral liquid (325 mg-10 mg-12.5 mg/5 mL)
Drug class: Upper respiratory combinations

Usage of Acetaminophen, dextromethorphan, and diphenhydramine

Acetaminophen is a pain reliever and fever reducer. Dextromethorphan is a cough suppressant. Diphenhydramine is an antihistamine.

Acetaminophen, diphenhydramine, and dextromethorphan is a combination medicine used to treat headache, fever, body aches, cough, runny nose, sneezing, and sore throat caused by allergies, the common cold, or the flu.

acetaminophen, dextromethorphan, and diphenhydramine will not treat a cough that is caused by smoking, asthma, or emphysema.

Acetaminophen, diphenhydramine, and dextromethorphan may also be used for purposes not listed in this medication guide.

Acetaminophen, dextromethorphan, and diphenhydramine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

This medicine may cause serious side effects. Stop using this medicine and call your doctor at once if you have:

fast, pounding, or uneven heartbeats;

severe drowsiness;

painful or difficult urination;

severe headache, seizure; or

liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects of acetaminophen, dextromethorphan, and diphenhydramine may include:

drowsiness;

headache, sleep problems (insomnia);

upset stomach, diarrhea or constipation;

dry eyes, blurred vision;

dry mouth, nose, or throat; or

feeling restless or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Acetaminophen, dextromethorphan, and diphenhydramine

Ask a doctor before taking medicine that contains acetaminophen if you have ever had liver disease, or if you drink more than 3 alcoholic beverages per day.

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:

a cough with mucus;

liver disease;

an enlarged prostate or urination problems;

asthma, chronic obstructive pulmonary disease (COPD), emphysema, or other breathing disorder;

glaucoma; or

a condition for which you take warfarin (Coumadin, Jantoven).

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Relate drugs

How to use Acetaminophen, dextromethorphan, and diphenhydramine

Usual Adult Dose for Cold Symptoms:

Dextromethorphan 10 mg/ diphenhydramine 12.5 mg/ paracetamol 325 mg per 5 mL oral liquid: 10 mL every 4 to 6 hoursMaximum dose: 6 doses per 24 hours

Usual Adult Dose for Influenza:

Dextromethorphan 10 mg/ diphenhydramine 12.5 mg/ paracetamol 325 mg per 5 mL oral liquid: 10 mL every 4 to 6 hoursMaximum dose: 6 doses per 24 hours

Usual Pediatric Dose for Cold Symptoms:

Dextromethorphan 10 mg/ diphenhydramine 12.5 mg/ paracetamol 325 mg per 5 mL oral liquid:12 years and older: 10 mL every 4 to 6 hoursMaximum dose: 6 doses per 24 hours6 to under 12 years: 5 mL every 4 to 6 hoursMaximum dose: 5 doses per 24 hours

Usual Pediatric Dose for Influenza:

Warnings

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Use this medicine exactly as directed. An overdose of acetaminophen can damage your liver or cause death. Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.

Do not use this medicine to make a child sleepy. Ask a doctor before giving the medicine to a child younger than 12 years old.

Ask a doctor or pharmacist before using any other medicine that may contain acetaminophen or diphenhydramine. Taking too much of either medicine can lead to a fatal overdose.

Drinking alcohol may increase your risk of liver damage while taking acetaminophen.

Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

What other drugs will affect Acetaminophen, dextromethorphan, and diphenhydramine

Ask a doctor or pharmacist before using acetaminophen, dextromethorphan, and diphenhydramine with any other medicines, especially drugs that can cause drowsiness (such as opioid medication, sleep medicine, a muscle relaxer, or medicine for anxiety or seizures). Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

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