Acetazolamide (Intravenous)

Generic name: Acetazolamide

Usage of Acetazolamide (Intravenous)

Acetazolamide injection is used to treat edema (fluid retention) caused by heart failure or other medicines. This medicine is also used to treat seizures (eg, petit mal, unlocalized seizures). It is also used to treat open-angle glaucoma, secondary glaucoma, and acute angle-closure glaucoma before surgery to lower pressure inside the eye.

This medicine is to be given only by or under the supervision of your doctor.

Acetazolamide (Intravenous) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

  • Black, tarry stools
  • blistering, peeling, or loosening of the skin
  • blood in the urine
  • bloody nose
  • change in consciousness
  • chest pain or tightness
  • chills
  • clay-colored stools
  • confusion
  • cough or hoarseness
  • dark urine
  • diarrhea
  • difficulty swallowing
  • dizziness
  • drowsiness
  • fever
  • frequent urination
  • headache
  • heavier menstrual periods
  • hives, itching, skin rash
  • increased volume of pale, dilute urine
  • itching
  • joint or muscle pain
  • loss of appetite
  • loss of consciousness
  • lower back or side pain
  • muscle tremors
  • nausea
  • no muscle tone or movement
  • painful or difficult urination
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the face, lips, or tongue
  • rash
  • red irritated eyes
  • red skin lesions, often with a purple center
  • restlessness
  • seizures
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • stomach pain or cramps
  • sudden decrease in amount of urine
  • sugar in the urine
  • swollen or painful glands
  • trouble breathing
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  • unusual tiredness or weakness
  • vomiting of blood
  • weight loss
  • yellow eyes or skin

    • Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    Incidence not known

  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • changes in vision
  • continuing ringing or buzzing or other unexplained noise in the ears
  • hearing loss
  • increased sensitivity of skin to sunlight
  • redness or other discoloration of the skin
  • severe sunburn

    • Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

    Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

    Before taking Acetazolamide (Intravenous)

    In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

    Allergies

    Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

    Pediatric

    Appropriate studies have not been performed on the relationship of age to the effects of acetazolamide injection in the pediatric population. Safety and efficacy have not been established.

    Geriatric

    No information is available on the relationship of age to the effects of acetazolamide injection in geriatric patients.

    Breast Feeding

    There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

    Interactions with Medicines

    Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Methenamine

    • Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amphetamine
  • Arsenic Trioxide
  • Aspirin
  • Benzphetamine
  • Carbamazepine
  • Dextroamphetamine
  • Digitalis
  • Droperidol
  • Levoketoconazole
  • Levomethadyl
  • Lisdexamfetamine
  • Lithium
  • Memantine
  • Metformin
  • Methamphetamine
  • Methotrexate
  • Porfimer
  • Primidone
  • Proscillaridin
  • Quinidine
  • Sotalol
  • Topiramate

    • Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aminolevulinic Acid
  • Cyclosporine
  • Fosphenytoin
  • Licorice
  • Phenytoin
  • Salsalate

    • Interactions with Food/Tobacco/Alcohol

    Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

    Other Medical Problems

    The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Adrenal gland problem or
  • Glaucoma, noncongestive angle-closure or
  • Hypokalemia (low potassium levels in the blood) or
  • Hyponatremia (low sodium levels in the blood) or
  • Kidney disease or
  • Liver disease (eg, cirrhosis) or
  • Metabolic acidosis—Should not be used in patients with these conditions.
  • Lung problems (eg, emphysema)—Use with caution. May make this condition worse.

    • How to use Acetazolamide (Intravenous)

    A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins.

    Warnings

    It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

    This medicine may cause serious skin reactions (eg, Stevens-Johnson syndrome and toxic epidermal necrolysis). Check with your doctor if you have blistering, peeling, or loosening of the skin, chills, cough, diarrhea, itching, joint or muscle pain, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness.

    Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

    This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Check with your doctor right away if you have chest tightness, cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, skin rash, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, trouble breathing, or unusual tiredness or weakness.

    Check with your doctor right away if you have blood in the urine, nausea and vomiting, pain in the groin or genitals, or sharp back pain just below the ribs. These may be symptoms of kidney stones.

    Check with your doctor right away if you have chest pain or tightness, chills, cough or hoarseness, fever with or without chills, general feeling of tiredness or weakness, headache, lower back or side pain, painful or difficult urination, sore throat, sores, ulcers, or white spots in the mouth, swollen or painful glands, trouble breathing, unusual bleeding or bruising, or unusual tiredness or weakness. These maybe symptoms of serious blood problems (eg, agranulocytosis, aplastic anemia).

    Receiving this medicine together with aspirin may cause change or loss of consciousness, loss of appetite, rapid shallow breathing, trouble breathing, or weight loss. Talk with your doctor if you have any concerns about this.

    Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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