Acetohydroxamic acid

Generic name: Acetohydroxamic Acid
Brand names: Lithostat
Dosage form: oral tablet (250 mg)
Drug class: Miscellaneous genitourinary tract agents

Usage of Acetohydroxamic acid

Acetohydroxamic acid helps prevent a build-up of ammonia in urine that can be caused by a bladder infection. Increased ammonia in urine can cause the growth of kidney stones.

Acetohydroxamic acid is used to keep urine ammonia levels low in people who have a certain type of chronic bladder infection.

Acetohydroxamic acid is not an antibiotic and will not treat the infection itself. acetohydroxamic acid is only part of a treatment program that may also include antibiotics to treat the infection, and surgery to remove kidney stones. Follow your doctor's instructions very closely.

Acetohydroxamic acid may also be used for purposes not listed in this medication guide.

Acetohydroxamic acid side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Acetohydroxamic acid may cause serious side effects. Call your doctor at once if you have:

pounding heartbeats or fluttering in your chest;

signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs; or

signs of a red blood cell disorder--pale or yellowed skin, dark colored urine, fever, confusion or weakness.

Common side effects of acetohydroxamic acid may include:

headache during the first 2 days of treatment;

skin rash, warmth, tingling or redness (especially if you drink alcohol while taking acetohydroxamic acid);

upset stomach, nausea, loss of appetite;

depressed mood;

anxiety, tremors, nervousness; or

hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Acetohydroxamic acid

You should not use acetohydroxamic acid if you are allergic to it, or if you have:

kidney disease;

bladder symptoms that have not been checked by a doctor with lab tests; or

if you are pregnant or are not using birth control.

To make sure acetohydroxamic acid is safe for you, tell your doctor if you have:

liver disease;

hemolytic anemia (a lack of red blood cells); or

a weak immune system.

FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not use acetohydroxamic acid if you are pregnant. Use effective birth control to prevent pregnancy while taking acetohydroxamic acid. Tell your doctor right away if you become pregnant or if you stop using birth control for any reason during treatment with this medicine.

It is not known whether acetohydroxamic acid passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Relate drugs

How to use Acetohydroxamic acid

Usual Adult Dose for Urinary Tract Infection:

Initial dose: 12 mg/kg/day orally every 6 to 8 hours Maintenance dose: 250 mg orally 3 to 4 times a day in a total daily dose of 10 to 15 mg/kg/dayMaximum dose: 1.5 g daily (regardless of body weight)Comments:-Long-term treatment with this drug may be warranted to maintain urease inhibition if urea-splitting infection is present. -Experience with this drug does not go beyond 7 years. Use: As adjunctive therapy in patients with chronic urea-splitting urinary infection. This drug is intended to decrease urinary ammonia and alkalinity, but it should not be used in lieu of curative surgical treatment (for patients with stones) or antimicrobial treatment.

Usual Pediatric Dose for Urinary Tract Infection:

10 mg/kg/day orally in 2 to 3 divided doses for up to 1 yearComments:-Children with chronic, recalcitrant, urea-splitting urinary infection may benefit from treatment with this drug; however, studies involving dosage and dose intervals in children have not been established.-Close monitoring of the patient and hematologic status is recommended. -Titration of the dose to higher or lower levels may be required to obtain an optimum therapeutic effect and/or to reduce the risk of side effects.Use: As adjunctive therapy in patients with chronic urea-splitting urinary infection. This drug is intended to decrease urinary ammonia and alkalinity, but it should not be used in lieu of curative surgical treatment (for patients with stones) or antimicrobial treatment.

Warnings

You should not use acetohydroxamic acid if you have kidney disease, or if you have bladder symptoms that have not been checked by a doctor.

acetohydroxamic acid can harm an unborn baby or cause birth defects. Do not use acetohydroxamic acid if you are pregnant or if you are not using birth control.

What other drugs will affect Acetohydroxamic acid

Other drugs may interact with acetohydroxamic acid, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Disclaimer

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