Acitretin

Generic name: Acitretin
Dosage form: oral capsule (10 mg; 17.5 mg; 25 mg)
Drug class: Antipsoriatics

Usage of Acitretin

Acitretin is a retinoid, which is a form of vitamin A.

Acitretin is used to treat severe psoriasis in adults. Acitretin is not a cure for psoriasis, and you may relapse after you stop taking this medication.

Acitretin may also be used for purposes not listed in this medication guide.

Acitretin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Acitretin may cause serious side effects. Stop using acitretin and call your doctor at once if you have:

mood changes--depression, aggression, unusual thoughts or behavior, thoughts of hurting yourself;

heart attack or stroke symptoms--chest pain, dizziness, nausea, feeling short of breath, sudden numbness or weakness (especially on one side of the body), sudden severe headache, problems with speech or balance, swelling or warmth in one or both legs;

high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor, headache, blurred vision;

increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;

liver problems--nausea, vomiting, loss of appetite, dark urine, or jaundice (yellowing of your skin or eyes);

problems with your bones or muscles--loss of feeling in your hands or feet, trouble moving, pain in your back, joints, muscles, or bones;

serious skin problems--itching, redness, pain, swelling or peeling of your skin; or

signs of a blood vessel problem--sudden swelling, rapid weight gain, fever, muscle pain, feeling light-headed.

Common side effects of acitretin may include:

chapped lips, dry mouth;

itchy or scaly skin;

weak nails, fragile skin;

peeling skin on your hands and feet;

hair loss;

dry eyes, discomfort while wearing contact lenses;

dry or runny nose, nosebleeds; or

joint pain, tight muscles.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Acitretin

You should not take this medicine if you are allergic to any retinoid (acitretin, isotretinoin, tretinoin, Accutane, Claravis, Myorisan, Refissa, Renova, Retin-A, and others), or if:

you have severe liver disease or severe kidney disease;

you have high levels of triglycerides (a type of fat) in your blood;

you are pregnant or breast-feeding;

you are also using methotrexate; or

you also use a tetracycline antibiotic (such as demeclocycline, doxycycline, minocycline, tetracycline, and others).

Acitretin is available to women only under an agreement that you will use approved birth control methods and undergo required pregnancy testing while taking this medicine and for at least 3 years after your last dose.

For women taking acitretin who have not had a hysterectomy or have not gone completely through menopause: Before you start taking acitretin you must have 2 negative pregnancy tests (when your doctor first prescribes acitretin, and again during the first 5 days of your menstrual period just before you start taking this medicine). You will also need pregnancy tests every month while you are taking acitretin, and every 3 months for at least 3 years after your last dose.

Acitretin can cause severe birth defects. Do not use acitretin if you are pregnant or if you might become pregnant within 3 years after you stop taking this medicine. You must use 2 effective forms of birth control to avoid getting pregnant while taking acitretin and for at least 3 years after your last dose.

The first birth control method should include one of the following forms:

birth control pills (but not the "mini-pill");

an intrauterine device (IUD);

birth control shots, inserts, skin patches, or implants;

a tubal ligation; or

your male partner's vasectomy.

The second birth control method should include one of the following forms:

a diaphragm or cervical cap used with a spermicide;

a latex condom used with or without a spermicide; or

a vaginal sponge that contains a spermicide.

Start using both forms of birth control at least 1 month before you start taking acitretin. Continue using both forms while you are taking acitretin and for at least 3 years after your last dose. Use both forms of birth control together every time you have sex.

While taking acitretin and for at least 3 years after your last dose: Call your doctor right away if you think you might be pregnant, if you miss a period, or if you have sex without using both forms of birth control. You may also call the MedWatch program at 1-800-FDA-1088. Consider using emergency contraception ("morning-after pill") if you have sex without using both of the 2 recommended birth control methods.

If you are not menstruating, you should have a pregnancy test at least 11 days after you last had sex without using 2 effective forms of birth control.

Do not miss a scheduled pregnancy test or you may not be able to continue taking acitretin.

Acitretin can pass into breast milk and may cause serious side effects in the nursing baby. Do not breast-feed while using this medicine.

To make sure acitretin is safe for you, tell your doctor if you have ever had:

phototherapy;

kidney or liver disease;

heart disease;

high cholesterol or triglycerides (a type of fat in the blood);

diabetes (you may need to check your blood sugar more often);

a habit of drinking large amounts of alcohol;

depression; or

if you have ever used a medicine called etretinate (Tegison, Tigason).

Relate drugs

How to use Acitretin

Usual Adult Dose for Psoriasis:

Initial dose: 25 to 50 mg orally once a day, administered as a single dose with main mealMaintenance dose: 25 to 50 mg orally once a day, administered upon an individual patient's response to initial treatmentComments: When used with phototherapy, the healthcare provider should decrease the phototherapy dose, dependent on the patient's individual response.Use: Treatment of severe psoriasis in adults

Warnings

Acitretin can cause severe birth defects. Do not use acitretin if you are pregnant or if you might become pregnant within 3 years after you stop taking acitretin.

You must use effective birth control to avoid getting pregnant while taking acitretin and for at least 3 years after your last dose. You will need pregnancy tests at regular intervals to make sure you are not pregnant.

Women who are able to get pregnant must not drink alcohol while taking acitretin and for at least 2 months after the last dose. Alcohol can cause acitretin to convert to another substance in your body that can take 3 years or longer to clear from your body.

Men or women should not donate blood while taking acitretin and for at least 3 years after the last dose. If donated blood containing acitretin is given to a pregnant woman, it could cause birth defects.

Acitretin can cause serious liver problems. Stop taking this medicine and call your doctor right away if you have symptoms such as nausea, vomiting, loss of appetite, dark urine, or jaundice (yellowing of your skin or eyes).

What other drugs will affect Acitretin

Tell your doctor about all your current medicines and any you start or stop using, especially:

glyburide;

phenytoin;

St. John's wort; or

hormone replacement therapy or birth control pills (especially "minipills").

This list is not complete. Other drugs may interact with acitretin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Disclaimer

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