Actos

Generic name: Pioglitazone (oral)
Drug class: Thiazolidinediones

Usage of Actos

Actos is an oral diabetes medicine that helps control blood sugar levels.

Actos is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Actos is not for treating type 1 diabetes.

Actos side effects

Get emergency medical help if you have signs of an allergic reaction to Actos: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Actos and call your doctor at once if you have symptoms of liver damage: nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Call your doctor at once if you have:

shortness of breath (especially when lying down), unusual tiredness, swelling, rapid weight gain;

pink or red urine, painful or difficult urination, new or worsening urge to urinate;

changes in your vision; or

sudden unusual pain in your hand, arm, or foot.

Some people taking this medicine have had bladder cancer, but it is not clear if pioglitazone was the actual cause.

Common Actos side effects may include:

headache;

muscle pain; or

cold symptoms such as stuffy nose, sinus pain, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Actos

You should not use Actos if you are allergic to pioglitazone, or if you have:

severe or uncontrolled heart failure; or

diabetic ketoacidosis (call your doctor for treatment).

This medication may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.

To make sure Actos is safe for you, tell your doctor if you have ever had:

congestive heart failure or heart disease;

a heart attack or stroke;

eye problems caused by diabetes;

bladder cancer; or

liver disease.

Actos may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Follow your doctor's instructions about using Actos if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

Pioglitazone may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

Women may be more likely to have a broken bone while using Actos. Talk with your doctor about ways to keep your bones healthy.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Actos is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Actos

Usual Adult Dose for Diabetes Type 2:

-Patients without congestive heart failure: Initial dose: 15 mg or 30 mg orally once a day -Patients with congestive heart failure (New York Heart Association [NYHA] Class I or II): Initial dose: 15 mg orally once a day Maintenance dose: 15 mg to 45 mg orally once a day based on glycemic response as determined by HbA1c Maximum dose: 45 mg orally once a day Comments: -This drug exerts its antihyperglycemic effect only in the presence of endogenous insulin and therefore is not expected to be effective in patients with type 1 diabetes mellitus or diabetic ketoacidosis. -Patients concomitantly receiving an insulin secretagogue or insulin may need to reduce the dose of the insulin secretagogue or insulin if hypoglycemia occurs. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus in multiple clinical settings

Warnings

You should not use Actos if you have severe or uncontrolled heart failure, active bladder cancer, or diabetic ketoacidosis (call your doctor for treatment with insulin). This medicine is not for treating type 1 diabetes.

Actos can cause or worsen congestive heart failure. Stop using this medicine and call your doctor at once if you have shortness of breath (even with mild exertion), swelling, or rapid weight gain.

What other drugs will affect Actos

Tell your doctor if you use insulin. Taking Actos while you are using insulin may increase your risk of serious heart problems.

Many drugs can interact with pioglitazone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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