Adagrasib

Generic name: Adagrasib
Brand names: Krazati
Dosage form: oral tablet (200 mg)
Drug class: Miscellaneous antineoplastics

Usage of Adagrasib

Adagrasib is used to treat adults with non-small cell lung cancer:

  • that has spread to other parts of the body or cannot be removed by surgery, and
  • has a specific gene marker (an abnormal "KRAS G12C" gene), and
  • who have received at least one treatment for cancer.

    • Your doctor will perform tests to make sure adagrasib is the right treatment for you.

    Adagrasib may also be used for purposes not listed in this medication guide.

    Adagrasib side effects

    Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

    Adagrasib may cause serious side effects. Call your doctor at once if you have:

  • nausea, diarrhea, or vomiting;
  • shortness of breath, cough or fever;
  • fast or pounding heartbeats, fluttering in your chest, and sudden dizziness (like you might pass out);
  • stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
  • liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

    • Common side effects of adagrasib may include:

  • nausea, diarrhea, vomiting;
  • tiredness;
  • muscle and bone pain;
  • trouble breathing;
  • loss of appetite; or
  • swelling, urinating less, feeling tired or short of breath.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Adagrasib

    Tell your doctor if you have ever had:

  • heart problems, including heart failure and congenital long QT syndrome; or
  • liver problems.

    • Adagrasib may harm an unborn baby. Tell your doctor if you are pregnant.

    Adagrasib may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using adagrasib.

    Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

    Relate drugs

    How to use Adagrasib

    Usual Adult Dose for Non-Small Cell Lung Cancer:

    600 mg orally twice dailyDuration of therapy: Until disease progression or unacceptable toxicity.Comments:-Administer this drug at the same time every day, with or without food.-If a dose of this drug is missed by more than 4 hours, skip the dose and resume dosing at the next scheduled time.-In case of vomiting after taking a dose, do not take another dose. Resume dosing at the next scheduled time.Use: For the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC), who received at least one prior treatment for their cancer.

    Warnings

    Call your doctor at once if you have bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds, loss of appetite, stomach pain (upper right side), dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

    What other drugs will affect Adagrasib

    Adagrasib can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

    Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

    Other drugs may affect adagrasib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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