Adempas
Generic name: Riociguat
Drug class:
Vasodilators
Usage of Adempas
Adempas lowers blood pressure in your lungs, helping your heart pump blood more efficiently.
Adempas is used to treat chronic thromboembolic pulmonary hypertension (CTEPH) in people who cannot be treated with surgery, or in people who have undergone surgery but still have symptoms. Riociguat can treat certain symptoms of CTEPH and can improve your ability to exercise.
Adempas is also used to treat pulmonary arterial hypertension (PAH). Riociguat can improve your ability to exercise and help prevent PAH from getting worse.
Adempas is available to women only under a special program. You must be registered in the program and understand the risks and benefits of this medicine.
Adempas side effects
Get emergency medical help if you have signs of an allergic reaction to Adempas: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using Adempas and call your doctor at once if you have:
Common Adempas side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Adempas
You should not use Adempas if you are allergic to riociguat, or if:
Some medicines can cause unwanted or dangerous effects when used with Adempas. Your doctor may change your treatment plan if you also use:
Do not take Adempas within 24 hours before or after taking sildenafil (Revatio, Viagra), or within 24 hours before or 48 hours after taking tadalafil (Adcirca, Cialis).
To make sure Adempas is safe for you, tell your doctor if you have ever had:
Do not use Adempas if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 month after your treatment ends. Tell your doctor right away if you miss a menstrual period or think you may have become pregnant during treatment.
You will need to have a negative pregnancy test before starting this treatment. You will also be re-tested every month during your treatment, and 1 month after you stop taking this medicine. Do not have unprotected sex.
While taking Adempas, girls and women who are able to get pregnant must use highly effective birth control, or two methods together.
Even if you are not planning a pregnancy, you are considered able to become pregnant if:
Adempas comes with patient instructions about acceptable forms of birth control to use while taking this medicine. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
Even if your sexual partner has had a vasectomy, you must still use a second method of birth control--either a barrier method or a hormonal form (birth control pills, injections, skin patch, or vaginal ring).
If you are the parent or caregiver of a female child taking this medication, talk to the child's doctor once you notice any signs of puberty (breast development or pubic hair), even if menstrual periods have not yet begun.
You should not breast-feed while using this medicine.
Relate drugs
- Adempas
- Apresoline
- Apresoline (Hydralazine Injection)
- Apresoline (Hydralazine Oral)
- Hydralazine
- Hydralazine (Injection)
- Hydralazine (Oral)
- Loniten
- Minoxidil
- Minoxidil (Oral)
- Natrecor
- Nesiritide
- Novaplus HydrALAZINE Hydrochloride
- Riociguat
- Vericiguat
- Verquvo
How to use Adempas
Usual Adult Dose for Pulmonary Hypertension:
Initial dose: 1 mg orally 3 times a day Maximum dose: 2.5 mg orally 3 times a day Comments: -For patients who cannot tolerate the hypotensive effect, consider a starting dose of 0.5 mg orally 3 times a day. If systolic blood pressure remains greater than 95 mmHg and the patient has no signs of hypotension, the dose may be titrated up by 0.5 mg orally 3 times a day. -Dose increases should be no more frequent than every 2 weeks. Uses: -Persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) (WHO group 4) after surgical treatment or inoperable CTEPH to improve exercise capacity and WHO functional class. -As monotherapy or in combination with endothelin receptor antagonists or prostanoids to treat pulmonary arterial hypertension (PAH) (WHO group 1) to improve exercise capacity, improve WHO functional class and to delay clinical worsening.
Warnings
Adempas can cause birth defects. Do not use if you are pregnant. You must use highly effective birth control while taking Adempas and for at least 1 month after your last dose. Do not have unprotected sex.
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with riociguat, and some drugs should not be used together.
What other drugs will affect Adempas
Other drugs may interact with riociguat, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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