Adstiladrin

Generic name: Nadofaragene Firadenovec-vncg
Dosage form: suspension for intravesical use
Drug class: Miscellaneous antineoplastics

Usage of Adstiladrin

Adstiladrin is a prescription gene therapy used for the treatment of a certain type of bladder cancer.

Adstiladrin contains nadofaragene firadenovec-vncg, a non-replicating adenovirus vector-based gene therapy containing the gene interferon alfa-2b.

Adstiladrin is administered directly into the bladder every three months. The treatment delivers the interferon alfa-2b gene into the cells of the bladder wall, which results in the cells secreting high quantities of interferon alfa-2b protein, a naturally occurring protein the body uses to fight cancer.

Adstiladrin side effects

The most common side effects include:

Urinary discharge

Fatigue

Bladder spasm

Urgency to urinate

Blood in your urine

These are not all the possible side effects. For more information, ask your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Ferring Pharmaceuticals at 1 888 337-7464.

Before taking Adstiladrin

You should not receive this treatment if you have a sensitivity to interferon alfa or any of its components.

Relate drugs

How to use Adstiladrin

Usual Adult Dose of Adstiladrin for Bladder Cancer

75 mL at a concentration of 3 x 1011 viral particles (vp)/mL, instilled once every three (3) months.

Comments: - Premedication with an anticholinergic is recommended before each instillation. - Administer by intravesical instillation only. - Allow the Adstiladrin to be left in the bladder for 1 hour following instillation.

Use: for the treatment of adult patients with high-risk Bacillus CalmetteGuérin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without papillary tumors.

Warnings

People who are immunosuppressed or immune-deficient should not prepare, administer, receive or come into contact with Adstiladrin.

What other drugs will affect Adstiladrin

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Adstiladrin is administered into the bladder directly, so is it is unlikely to interact with other medicines.

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