Aducanumab
Generic name: Aducanumab
Brand names: Aduhelm
Dosage form: intravenous solution (avwa 100 mg/mL)
Drug class:
Miscellaneous central nervous system agents
Usage of Aducanumab
Aducanumab is used to treat adults with Alzheimer's disease.
Aducanumab may also be used for purposes not listed in this medication guide.
Aducanumab side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.
Aducanumab can cause temporary swelling or bleeding in the brain. Call your doctor if you have:
Common side effects of aducanumab may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Aducanumab
Aducanumab can cause a condition called Amyloid Related Imaging Abnormalities or "ARIA."
ARIA is a temporary swelling or small spots of bleeding in the brain that usually clears up with time. Your doctor may perform an MRI of your brain before and during your treatment with aducanumab. Ask your doctor about your risk.
It is not known if aducanumab will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Ask a doctor if it is safe to breastfeed while using aducanumab.
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How to use Aducanumab
Usual Adult Dose for Alzheimer's Disease:
Titration is required for treatment initiation: Doses are infused over 1 hour every 4 weeks: -Infusion 1 and 2: 1 mg/kg IV -Infusion 3 and 4: 3 mg/kg IV -Infusion 5 and 6: 6 mg/kg IV Maintenance dose: 10 mg/kg IV once every 4 weeksComments:-Administer via IV infusion approximately every 4 weeks and at least 21 days apart. -Study patients in the clinical trials had mild cognitive impairment or mild dementia stage of disease; there are no safety oreffectiveness data on initiating treatment at earlier or later stages of the disease than were studied. -This drug has been approved under an accelerated approval based on reduction in amyloid beta plaques observed in patients treated in clinical studies; continued approval may be contingent upon verification of clinical benefit in confirmatory trials. Use: For the treatment of Alzheimer's disease in patients with mild cognitive impairment or mild dementia stage of disease.
Warnings
Aducanumab can cause temporary swelling or bleeding in the brain that usually clears up with time. This may cause no symptoms but can be serious. Call your doctor if you have headaches, dizziness, nausea, confusion, or vision changes.
What other drugs will affect Aducanumab
Tell your doctor about all your other medicines, especially medicines to treat or prevent blood clots, including aspirin.
Other drugs may affect aducanumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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