Afinitor Disperz

Generic name: Everolimus (Afinitor)

Usage of Afinitor Disperz

This medication guide provides information about the Afinitor brand of everolimus. Zortress is another brand of everolimus used to prevent organ rejection after a kidney transplant.

The Afinitor brand of everolimus is used to treat certain types of kidney cancer, breast cancer, or brain tumor. Afinitor is also used to treat certain types of advanced or progressive tumors of the stomach, intestines, or pancreas.

Afinitor is also used to treat certain types of seizures or non-cancerous (benign) tumors of the brain or kidney in people with a genetic condition called tuberous sclerosis complex.

Everolimus may also be used for purposes not listed in this medication guide.

Afinitor Disperz side effects

Get emergency medical help if you have signs of an allergic reaction: hives; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have some of these symptoms if you also take an "ACE inhibitor" heart or blood pressure medication.

Afinitor Disperz may cause serious side effects. Call your doctor at once if you have:

  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
  • lung problems--new or worsening cough, chest pain, wheezing, feeling short of breath;
  • signs of infection--fever, chills, tiredness, joint pain, skin rash;
  • kidney problems--little or no urination; swelling in your feet or ankles;
  • liver problems--nausea, loss of appetite, stomach pain (upper right side), dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • low blood cell counts--flu-like symptoms, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed;
  • any wound that will not heal; or
  • a surgical incision that is red, warm, swollen, painful, bleeding, or oozing pus.
  • Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

    Common side effects of Afinitor Disperz may include:

  • fever, cough, infections, feeling weak or tired;
  • mouth sores;
  • nausea, loss of appetite;
  • swelling anywhere in your body;
  • rash;
  • missed menstrual periods;
  • headache; or
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Afinitor Disperz

    You should not use Afinitor Disperz if you are allergic to everolimus, sirolimus (Rapamune), or temsirolimus (Torisel).

    Tell your doctor if you have ever had:

  • an active or chronic infection;
  • liver disease, especially hepatitis B;
  • kidney disease;
  • diabetes or high blood sugar;
  • high cholesterol;
  • if you are scheduled to receive any vaccine; or
  • high blood pressure.
  • Afinitor can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.

  • If you are a woman, do not use Afinitor if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 8 weeks after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 weeks after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Afinitor.
  • This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because Afinitor can harm an unborn baby.

    You should not breastfeed while using this medicine and for at least 2 weeks after your last dose.

    How to use Afinitor Disperz

    Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

    Take Afinitor at the same time each day. You may take the medicine with or without food, but take it the same way each time.

    Do not take an Afinitor regular tablet together with an Afinitor dispersible tablet. Use only one form of this medicine.

    Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

    Afinitor can increase your risk of bleeding or infection by changing the way your immune system works. You will need frequent medical tests.

    If you've ever had hepatitis B, using Afinitor can cause this virus to become active or get worse. You may need frequent liver function tests while using this medicine and for several months after you stop.

    Surgical incisions or other wounds may take longer to heal while you are taking Afinitor. You may need to stop taking this medicine for 1 week before and 2 weeks after a surgery. Follow your doctor's instructions.

    Store at room temperature in the original container, away from moisture, heat, and light. Keep unused dispersible tablets in the foil blister pack.

    Warnings

    Afinitor can cause serious and sometimes fatal side effects. Call your doctor right away if you have: signs of infection--fever, chills, skin rash, joint pain, tiredness; lung problems--cough, chest pain, wheezing, shortness of breath; kidney problems--swelling, little or no urination; or liver problems--loss of appetite, dark urine, yellowing of your skin or eyes, or upper stomach pain.

    If you have ever had hepatitis B, Afinitor can cause this condition to come back or get worse.

    You may be more likely to have an allergic reaction if you take an "ACE inhibitor" heart or blood pressure medication while you are taking Afinitor. Tell your doctor about all your current medicines and any you start or stop using.

    What other drugs will affect Afinitor Disperz

    Tell your doctor about all your current medicines. Many drugs can affect Afinitor, especially:

  • an antibiotic or antifungal medicine;
  • heart or blood pressure medication;
  • medicine to treat hepatitis C, or HIV/AIDS;
  • seizure medicine;
  • St. John's wort;
  • tuberculosis medication; or
  • drugs that weaken the immune system, such as cancer medicine, steroids, and medicines to prevent organ transplant rejection.
  • This list is not complete and many other drugs may affect Afinitor. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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