Akeega
Generic name: Niraparib And Abiraterone Acetate
Dosage form: tablets (50mg niraparib/500 mg abiraterone acetate, 100 mg niraparib/500 mg abiraterone acetate)
Drug class:
Antineoplastic combinations
Usage of Akeega
Akeega is a prescription medicine used to treat types of prostate cancer, it is used together with prednisone. Akeega contains niraparib and abiraterone acetate and is the first dual-action tablet combining a PARP inhibitor with abiraterone acetate.
Akeega is used for metastatic castration-resistant prostate cancer (mCRPC), that has an abnormal BRCA gene (BRCA-positive). This is prostate cancer that has spread to other parts of the body and no longer responds to medical or surgical treatment that lowers testosterone. Your doctor will perform a test to make sure this medicine right for you.
Akeega received FDA approval on 11 August, 2023, approval was based on positive results from the randomized, double-blind, placebo-controlled multi-center Phase 3 MAGNITUDE study.
Akeega side effects
The most common Akeega side effects:
Akeega may cause serious side effects
Bone marrow problems called myelodysplastic syndrome (MDS) or a type of cancer of the blood called acute myeloid leukemia (AML). See 'Important Information below for more details.
Low blood potassium levels (hypokalemia), fluid retention (edema), high blood pressure (hypertension) and heart problems. Tell your healthcare provider if you have any of the following symptoms
Liver problems. Severe liver problems, liver failure, and death has happened in people treated with abiraterone acetate, one of the active ingredients in Akeega. Tell your healthcare provider right away if you develop any symptoms of liver problems, including:
Adrenal problems. Adrenal problems may happen if you stop taking prednisone, get an infection, or are under stress. Tell your healthcare provider right away if you develop any symptoms of adrenal problems, including:
Low blood sugar (hypoglycemia). Akeega may cause low blood sugar in people taking medicines for diabetes. Severe low blood sugar has happened in people who take certain medicines for diabetes and were treated with abiraterone acetate, one of the active ingredients in Akeega. You and your healthcare provider should check your blood sugar levels during treatment and after you stop treatment with Akeega. Your healthcare provider may need to change the dose of your diabetes medicine to reduce your risk of low blood sugar. Tell your healthcare provider right away if you have any of the following signs or symptoms of low blood sugar, including:
Increased risk of bone fracture and death when abiraterone acetate, one of the active ingredient in this medicine, and prednisone or prednisolone is used in combination with a type of radiation called Radium 223 (Ra-223) dichloride. You should not receive treatment with Ra-223 dichloride for at least 5 days after your last dose of Akeega with prednisone. Tell your healthcare provider about any other treatments you are taking for prostate cancer.
Posterior Reversible Encephalopathy Syndrome (PRES). PRES is a condition that affects the brain and may happen during treatment with Akeega. If you have headache, vision changes, confusion, or seizure with or without high blood pressure, please contact your healthcare provider.
Fertility problems in males this medicine may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility.
These are not all the possible side effects of Akeega. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Akeega
Tell your healthcare provider about all of your medical conditions, including if you:
Pregnancy
Females: Tell your healthcare professional if you are pregnant, become pregnant or plan to become pregnant. Akeega can cause harm to your unborn baby and loss of pregnancy (miscarriage).
Females who are or may become pregnant should handle Akeega tablets with protection, such as gloves.
Males: with female partners who are able to become pregnant should use effective birth control (contraception) during treatment and for 4 months after the last dose of this medicine.
Akeega may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility.
Breastfeeding
Tell your healthcare provider if you are breastfeeding or plan to breastfeed. It is not known if Akeega passes into your breastmilk.
Relate drugs
- Akeega
- Cytarabine and daunorubicin liposomal
- Cedazuridine and decitabine
- Daunorubicin and cytarabine liposome
- Decitabine and cedazuridine
- Inqovi
- Kisqali Femara Co-Pack
- Kisqali Femara Co-Pack 200 mg-2.5 mg Dose
- Kisqali Femara Co-Pack 400 mg-2.5 mg Dose
- Kisqali Femara Co-Pack 600 mg-2.5 mg Dose
- Letrozole and ribociclib
- Lonsurf
- Niraparib and abiraterone
- Nivolumab and relatlimab
- Nivolumab/relatlimab-rmbw
- Opdualag
- Ribociclib and letrozole
- Tipiracil and trifluridine
- Trifluridine and tipiracil
- Vyxeos
- Vyxeos liposomal
How to use Akeega
The recommended adult dosage of Akeega is 200 mg niraparib/1,000 mg abiraterone acetate orally once daily in combination with 10 mg prednisone daily until disease progression or unacceptable toxicity.
Akeega is available as:
Warnings
Akeega may cause serious side effects including:
Bone marrow problems called myelodysplastic syndrome (MDS) or a type of cancer of the blood called acute myeloid leukemia (AML). MDS or AML that may lead to death has happened in people treated with niraparib, one of the active ingredients in Akeega. If you develop MDS or AML, your healthcare provider will stop treatment with this medicine. Symptoms of low blood cell counts (low red blood cells, low white blood cells, and low platelets) are common during treatment with Akeega but can also be a sign of serious bone marrow problems, including MDS and AML. Tell your healthcare provider if you have any of the following symptoms during treatment:
Your healthcare provider will do blood tests to check your blood cell counts:
What other drugs will affect Akeega
Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use. Tell your doctor about all your current medicines and any medicine you start or stop using.
You should not take the group of medicines called strong CYP3A4 inducers with Akeega. Examples of strong CYP3A4 inducers including apalutamide, carbamazepine, enzalutamide, ivosidenib, lumacaftor and ivacaftor, mitotane, phenytoin, rifampin, and St. John’s wort.
You should not take the group of medicines called CYP2D6 Substrates with Akeega, if a small change in concentration of your medicine may lead to serious toxicities. If alternative treatments cannot be used, consider a dose reduction of the concomitant CYP2D6 substrate.
Not all possible interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Popular Keywords
- metformin obat apa
- alahan panjang
- glimepiride obat apa
- takikardia adalah
- erau ernie
- pradiabetes
- besar88
- atrofi adalah
- kutu anjing
- trakeostomi
- mayzent pi
- enbrel auto injector not working
- enbrel interactions
- lenvima life expectancy
- leqvio pi
- what is lenvima
- lenvima pi
- empagliflozin-linagliptin
- encourage foundation for enbrel
- qulipta drug interactions