Alogliptin and metformin

Generic name: Alogliptin And Metformin
Brand names: Kazano
Dosage form: oral tablet (12.5 mg-1000 mg; 12.5 mg-500 mg)
Drug class: Antidiabetic combinations

Usage of Alogliptin and metformin

Alogliptin and metformin is a combination medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. alogliptin and metformin is not for treating type 1 diabetes.

Alogliptin and metformin may also be used for purposes not listed in this medication guide.

Alogliptin and metformin side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stop taking this medicine and call your doctor right away if you have symptoms of pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, or fast heartbeats.

Some people using metformin develop lactic acidosis, which can be fatal. Get emergency medical help if you have even mild symptoms such as:

unusual muscle pain;

feeling cold;

trouble breathing;

feeling dizzy, light-headed, tired, or very weak;

stomach pain, vomiting; or

slow or irregular heart rate.

Alogliptin and metformin may cause serious side effects. Call your doctor at once if you have:

severe or ongoing pain in your joints;

pain or burning when you urinate;

liver problems--nausea, upper stomach pain, tiredness, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes); or

symptoms of heart failure--shortness of breath (even while lying down), swelling in your legs or feet, rapid weight gain.

Common side effects of alogliptin and metformin may include:

diarrhea, upset stomach;

increased blood pressure (severe headache, blurred vision, pounding in your neck or ears);

back pain, headache; or

cold symptoms such as stuffy nose, sinus pain, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Alogliptin and metformin

You should not use this medicine if you are allergic to alogliptin or metformin, or if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you have ever had:

kidney disease;

heart disease;

liver disease;

pancreatitis;

gallstones; or

alcoholism.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking alogliptin and metformin. Be sure your caregivers know ahead of time that you are using this medicine.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

This medicine may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

This medicine is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Alogliptin and metformin

Usual Adult Dose for Diabetes Type 2:

Individualize initial dose based on patients current regimen; metformin dose should be gradually titrated upwards and taken with food to reduce the gastrointestinal side effects: Initial dose: alogliptin 12.5 mg-metformin 500 mg OR alogliptin 12.5 mg-metformin 1000 mg orally twice a day Maintenance dose: Adjust dose based on efficacy and tolerabilityMaximum dose: alogliptin 25 mg-metformin 2000 mg per dayComments: -When used in combination with insulin or insulin secretagogues such as sulfonylureas, a lower dose of insulin or the insulin secretagogue may be required to minimize the risk of hypoglycemia. Use: As an adjunct to diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both alogliptin and metformin is appropriate.

Warnings

You should not use alogliptin and metformin if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment).

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.

What other drugs will affect Alogliptin and metformin

Many drugs can affect alogliptin and metformin, making alogliptin and metformin less effective or increasing your risk of lactic acidosis. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.