Alprolix
Generic name: Coagulation Factor IX (Recombinant), Fc Fusion Protein
Dosage form: lyophilized powder for solution for intravenous injection
Drug class:
Miscellaneous coagulation modifiers
Usage of Alprolix
Alprolix is an injectable medicine that is used to help control and prevent bleeding in people with hemophilia B. Hemophilia B is also called congenital Factor IX deficiency.
Your healthcare provider may give you Alprolix when you have surgery.
Alprolix side effects
Common side effects include headache, abnormal sensation in the mouth, and pain in your side with blood in your urine, which may be a sign of clot formation in the urinary collecting system.
Allergic reactions may occur. Call your healthcare provider or get emergency treatment right away if you have any of the following symptoms: hives, chest tightness, wheezing, difficulty breathing, or swelling of the face.
Redness to the skin at the injection site may also occur.
Alprolix may increase the risk of forming abnormal blood clots in your body, especially if you have risk factors for developing blood clots. Call your healthcare provider or seek emergency care if you have symptoms of a possible abnormal blood clot, which may include: chest pain, difficulty breathing, unexpected swelling of an arm or leg with or without pain or tenderness.
Your body can also make antibodies called "inhibitors" against Alprolix, which may stop Alprolix from working properly. Your healthcare provider may need to test your blood for inhibitors from time to time.
These are not all the possible side effects.
Talk to your healthcare provider about any side effect that bothers you or that does not go away.
Before taking Alprolix
You should not use Alprolix if you are allergic to Alprolix or any of the other ingredients. Tell your healthcare provider if you have had an allergic reaction to any Factor IX product prior to using Alprolix.
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How to use Alprolix
On-demand treatment and control of bleeding episodes:
Initial Dose: Type of Bleeding Target Circulating FIX (IU/dL) Dosing Interval (hours) Minor and Moderate 30–60 Repeat every 48 hours as needed if there is further evidence of bleeding. Major 80–100 Consider repeat dose after 6–10 hours, then every 24 hours for 3 days, then every 48 hours until healing achieved.Perioperative management:
Routine prophylaxis:
For adults and adolescents ≥12 years of age, start at 50 IU/kg once weekly or 100 IU/kg once every 10 days. For children <12 years of age, start at 60 IU/kg once weekly. Adjust dosing regimen based on individual response. More frequent or higher doses may be needed in children <12 years of age.
Use: adults and children with hemophilia B for:
What other drugs will affect Alprolix
Tell your healthcare provider about all of the medicines you take, including all prescription and non-prescription medicines, such as over-the-counter medicines, supplements, or herbal medicines.
There are no known drugs interactions with Alprolix.
Disclaimer
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