Altuviiio
Generic name: Antihemophilic Factor (recombinant), Fc-VWF-XTEN Fusion Protein-ehtl
Drug class:
Miscellaneous coagulation modifiers
Usage of Altuviiio
Altuviiio is a once-weekly recombinant factor VIII replacement therapy that can be used by Hemophilia A patients routinely to prevent bleeding, or used on-demand to treat an acute bleed. Altuviiio works as a replacement for the missing coagulation factor VIII that hemophilia A patients need for effective blood clotting, so Altuviiio lowers their risk of bleeding.
Hemophilia is a genetic disorder that impairs the ability of a person’s blood to clot correctly, this leads to excessive and unexpected bleeding. Hemophilia A is caused by a missing or defective clotting protein called factor VIII (FVIII), which means the blood does not clot when it needs to. Patients with severe hemophilia A can have excessive spontaneous bleeds without apparent cause, this can be bleeding inside the body or outside the body. Patients with milder hemophilia A are likely only to have significant bleeding if they have surgery or after severe injury.
Altuviio is given as a weekly infusion to hemophilia A patients, as a replacement for their missing or defective factor VIII clotting protein, to decrease their risk of bleeding
Altuviiio is a first-in-class FDA-approved high-sustained factor VIII replacement therapy that is given as a once-weekly intravenous infusion. FDA approval was supported by data from the Phase 3 XTEND-1 study (NCT04161495) and XTEND-Kids study (NCT04759131).
Altuviiio side effects
Most common Altuviiio side effects are:
Before taking Altuviiio
Tell your doctor if you have had allergic reaction to Altuviiio is the past. Do not use Altuviiio is you have had a severe hypersensitivity reactions, including anaphylaxis, to Altuviiio or inactive ingredients contained in this medicine.
Pregnancy
Breastfeeding
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How to use Altuviiio
Altuviiio dose for:
Routine prophylaxis (adults and children)
On-demand Treatment and Control of Bleeding Episodes
Perioperative management
Available strenths of Altuviiio
Altuviiio strength is in international units (IU) of Factor VIII potency.
Altuviiio is available in the following strengths:
Warnings
Hypersensitivity Reactions: Allergic-type hypersensitivity reactions, including anaphylaxis, may occur using Altuviiio. Tell your doctor if you have any signs of an allergic reaction including, shortness of breath, wheezing, hives, chest tightness, hypotension, and itching. If you have hypersensitivity symptoms, you should discontinue the use of this medicine and contact a physician and/or seek immediate emergency care.
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