Amifampridine

Generic name: Amifampridine
Brand names: Firdapse
Dosage form: oral tablet (10 mg)
Drug class: Cholinergic muscle stimulants

Usage of Amifampridine

Amifampridine is used to treat Lambert-Eaton myasthenic syndrome in adults.

Amifampridine may also be used for purposes not listed in this medication guide.

Amifampridine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Amifampridine can cause seizures, even if you have never had a seizure in the past.

Stop using amifampridine and call your doctor at once if you have a seizure.

Common side effects of amifampridine may include:

tingly feeling in your hands, feet, face, mouth, or other parts of your body;

nausea, stomach pain, diarrhea;

headache, back pain;

increased blood pressure;

abnormal liver function tests;

muscle spasms; or

cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Amifampridine

You should not use amifampridine if you are allergic to it, or if:

you have had a seizure in the past; or

you are allergic to dalfampridine.

Tell your doctor if you have ever had:

a seizure;

liver disease;

kidney disease; or

if you also take a form of amifampridine obtained from a compounding pharmacy (3,4-diaminopyridine or 3,4-DAP).

Tell your doctor if you are pregnant or breast-feeding.

Relate drugs

How to use Amifampridine

Usual Adult Dose for Lambert-Eaton Myasthenic Syndrome:

-Initial dose: 15 mg to 30 mg orally once a day in divided doses (3 to 4 times daily)-Maximum single dose: 20 mg-Maximum daily dose: 80 mg/dayComments:-Dose may be increased by 5 mg daily every 3 or 4 days.-If a dose is missed, patients should not take double or extra doses.Use: For the treatment of Lambert-Eaton myasthenic syndrome (LEMS)

Usual Pediatric Dose for Lambert-Eaton Myasthenic Syndrome:

6 years to less than 17 years weighing less than 45 kg:-Initial dose: 7.5 mg to 15 mg orally once a day in divided doses (2 to 3 times daily) -Maximum single dose: 15 mg-Maximum daily dose: 50 mgComments:-Dose may be increased daily in 2.5 mg to 5 mg increments, divided in up to 5 doses daily.-Dosage should be increased based on clinical response and tolerability.-A suspension can be prepared when patients require a dosage in less than 5 mg increments.6 years to less than 17 years weighing 45 kg or more:-Initial dose: 15 mg to 30 mg daily in divided doses (2 to 3 times daily) -Maximum single dose: 30 m-Maximum daily dose: 100 mgComments:-Dose may be increased daily in 5 mg to 10 mg increments, divided in up to 5 doses daily.-Dosage should be increased based on clinical response and tolerability.Use: For the treatment of Lambert-Eaton myasthenic syndrome (LEMS)

Warnings

Amifampridine can cause seizures, even if you have never had a seizure in the past. Stop taking amifampridine and call your doctor right away if you have a seizure.

What other drugs will affect Amifampridine

Amifampridine can cause seizures, especially if you also use certain medicines for infections, asthma, depression, mental illness, attention deficit disorder, or severe pain.

Many drugs can affect amifampridine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.