Amifampridine

Generic name: Amifampridine
Brand names: Firdapse
Dosage form: oral tablet (10 mg)
Drug class: Cholinergic muscle stimulants

Usage of Amifampridine

Amifampridine is used to treat Lambert-Eaton myasthenic syndrome in adults.

Amifampridine may also be used for purposes not listed in this medication guide.

Amifampridine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Amifampridine can cause seizures, even if you have never had a seizure in the past.

Stop using amifampridine and call your doctor at once if you have a seizure.

Common side effects of amifampridine may include:

  • tingly feeling in your hands, feet, face, mouth, or other parts of your body;
  • nausea, stomach pain, diarrhea;
  • headache, back pain;
  • increased blood pressure;
  • abnormal liver function tests;
  • muscle spasms; or
  • cold symptoms such as stuffy nose, sneezing, sore throat.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Amifampridine

    You should not use amifampridine if you are allergic to it, or if:

  • you have had a seizure in the past; or
  • you are allergic to dalfampridine.
  • Tell your doctor if you have ever had:

  • a seizure;
  • liver disease;
  • kidney disease; or
  • if you also take a form of amifampridine obtained from a compounding pharmacy (3,4-diaminopyridine or 3,4-DAP).
  • Tell your doctor if you are pregnant or breast-feeding.

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    How to use Amifampridine

    Usual Adult Dose for Lambert-Eaton Myasthenic Syndrome:

    -Initial dose: 15 mg to 30 mg orally once a day in divided doses (3 to 4 times daily)-Maximum single dose: 20 mg-Maximum daily dose: 80 mg/dayComments:-Dose may be increased by 5 mg daily every 3 or 4 days.-If a dose is missed, patients should not take double or extra doses.Use: For the treatment of Lambert-Eaton myasthenic syndrome (LEMS)

    Usual Pediatric Dose for Lambert-Eaton Myasthenic Syndrome:

    6 years to less than 17 years weighing less than 45 kg:-Initial dose: 7.5 mg to 15 mg orally once a day in divided doses (2 to 3 times daily) -Maximum single dose: 15 mg-Maximum daily dose: 50 mgComments:-Dose may be increased daily in 2.5 mg to 5 mg increments, divided in up to 5 doses daily.-Dosage should be increased based on clinical response and tolerability.-A suspension can be prepared when patients require a dosage in less than 5 mg increments.6 years to less than 17 years weighing 45 kg or more:-Initial dose: 15 mg to 30 mg daily in divided doses (2 to 3 times daily) -Maximum single dose: 30 m-Maximum daily dose: 100 mgComments:-Dose may be increased daily in 5 mg to 10 mg increments, divided in up to 5 doses daily.-Dosage should be increased based on clinical response and tolerability.Use: For the treatment of Lambert-Eaton myasthenic syndrome (LEMS)

    Warnings

    Amifampridine can cause seizures, even if you have never had a seizure in the past. Stop taking amifampridine and call your doctor right away if you have a seizure.

    What other drugs will affect Amifampridine

    Amifampridine can cause seizures, especially if you also use certain medicines for infections, asthma, depression, mental illness, attention deficit disorder, or severe pain.

    Many drugs can affect amifampridine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

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