Amlodipine and perindopril

Generic name: Amlodipine And Perindopril
Brand names: Prestalia
Dosage form: oral tablet (10 mg-14 mg; 2.5 mg-3.5 mg; 5 mg-7 mg)
Drug class: ACE inhibitors with calcium channel blocking agents

Usage of Amlodipine and perindopril

Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow.

Perindopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Perindopril also widens blood vessels and also prevents the body from retaining water.

Amlodipine and perindopril is a combination medicine used to treat high blood pressure (hypertension).

Amlodipine and perindopril may also be used for purposes not listed in this medication guide.

Amlodipine and perindopril side effects

Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.

Amlodipine and perindopril may cause serious side effects. Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

swelling in your hands or feet, rapid weight gain;

little or no urinating;

new or worsened chest pain;

jaundice (yellowing of the skin or eyes); or

high potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement.

Common side effects of amlodipine and perindopril may include:

cough;

headache, dizziness; or

swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Amlodipine and perindopril

You should not use this medicine if you are allergic to amlodipine or perindopril, or if:

you have had angioedema (hives or severe swelling of deep skin tissues sometimes caused by allergic reaction);

you recently took a heart medicine called sacubitril; or

you are allergic to any other ACE inhibitor, such as captopril, enalapril, lisinopril, moexipril, quinapril, ramipril, Accupril, Prinivil, Mavik, Vasotec, and many others.

Do not take amlodipine and perindopril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not use amlodipine and perindopril together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking amlodipine and perindopril with aliskiren if you have kidney disease.

Tell your doctor if you have ever had:

heart disease or a heart attack;

high levels of potassium in your blood;

kidney disease (or if you are on dialysis);

liver disease; or

if you are on a low-salt diet.

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Perindopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not breast-feed while you are using this medicine.

Relate drugs

How to use Amlodipine and perindopril

Usual Adult Dose for Hypertension:

Initial dose: Amlodipine 2.5 mg-Perindopril 3.5 mg orally once a dayMaximum dose: Amlodipine 10 mg-Perindopril 14 mg orally once a dayComments:-Wait 7 to 14 days between titration steps.-May be used as initial therapy if multiple drugs are likely needed to achieve blood pressure goals.-In patients greater than 65 years old, monitor blood pressure up to 2 weeks following titrations at doses above amlodipine 5 mg-perindopril 7 mg.

Warnings

Do not use if you are pregnant. If you become pregnant, stop taking amlodipine and perindopril and tell your doctor right away.

You should not use this medicine if you have ever had angioedema. Do not take this medicine within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not use amlodipine and perindopril together with any medication that contains aliskiren (a blood pressure medicine).

What other drugs will affect Amlodipine and perindopril

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can affect amlodipine and perindopril, especially:

a diuretic or "water pill";

heart or blood pressure medication; or

NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete and many other drugs may affect amlodipine and perindopril. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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