Amoxicillin, clarithromycin, and omeprazole

Generic name: Amoxicillin, Clarithromycin, And Omeprazole
Brand names: Omeclamox-Pak
Dosage form: oral kit (500 mg-500 mg-20 mg)
Drug class: H. pylori eradication agents

Usage of Amoxicillin, clarithromycin, and omeprazole

Amoxicillin and clarithromycin are antibiotic that fight bacteria in the body. Omeprazole decreases the amount of acid produced in the stomach.

Amoxicillin, clarithromycin, and omeprazole (Omeclamox-Pak) is a combination medicine used to prevent stomach ulcer caused by infection with Helicobacter pylori (H. pylori).

Amoxicillin, clarithromycin, and omeprazole may also be used for purposes not listed in this medication guide.

Amoxicillin, clarithromycin, and omeprazole side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Amoxicillin, clarithromycin, and omeprazole may cause serious side effects. Call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);

fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

liver problems--upper stomach pain, itching, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);

kidney problems--nausea, loss of appetite, not feeling well, fever, rash, painful urination, pain in your side or lower back;

new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight; or

signs of new infection--fever, cough, tiredness, trouble breathing, sores or white patches in your mouth or throat, stomach pain, vomiting, neck pain, sensitivity to light.

Serious side effects may be more likely in older adults.

Taking amoxicillin, clarithromycin, and omeprazole long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.

Common side effects of amoxicillin, clarithromycin, and omeprazole may include:

diarrhea;

headache; or

unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Amoxicillin, clarithromycin, and omeprazole

You should not use amoxicillin, clarithromycin, and omeprazole if you are allergic to amoxicillin (Amoxil), clarithromycin (Biaxin), or omeprazole (Prevacid), or if:

you are allergic to azithromycin (Zithromax, Z-Pak), erythromycin, or telithromycin;

you are allergic to albendazole or mebendazole;

you have had a severe allergic reaction to a penicillin antibiotic, including ampicillin, Augmentin, Principen, Timentin, Trimox, and others; or

you have had a severe allergic reaction to a cephalosporin antibiotic such as cefdinir, cefprozil, cefuroxime, cephalexin, Duricef, Omnicef, Cefzil, Keflex, Spectracef, and others.

Some drugs should not be used with Omeclamox-Pak. Taking any of the following medicines together with amoxicillin, clarithromycin, and omeprazole can cause a life-threatening side effect on your heart:

ergotamine;

dihydroergotamine; or

pimozide.

Tell your doctor if you have ever had:

liver disease;

kidney disease;

allergies;

myasthenia gravis;

You may be more likely to have a broken bone while taking this medicine long term or more than once per day. Talk with your doctor about ways to keep your bones healthy.

May harm an unborn baby. Use birth control and tell your doctor if you become pregnant.

Amoxicillin can make birth control pills less effective. Ask your doctor about other birth control options such as an injection, implant, skin patch, vaginal ring, condom, diaphragm, cervical cap, or contraceptive sponge.

Do not breastfeed while using this medicine. If you use a breast pump during this time, throw out the milk and do not feed it to your baby.

Not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Amoxicillin, clarithromycin, and omeprazole

Usual Adult Dose for Duodenal Ulcer:

Amoxicillin 500 mg-clarithromycin 500 mg-omeprazole 20 mg orally 2 times a day-Duration of therapy: 10 daysComments:-Doses should be given in the morning and evening before eating a meal.-An additional 18 days of treatment with omeprazole 20 mg orally once a day is recommended for patients with an ulcer at initiation of treatment.Use: Eradication of Helicobacter pylori in patients with active duodenal ulcer of a history of duodenal ulcer disease

Usual Adult Dose for Helicobacter pylori Infection:

Warnings

Tell your doctor about all your other medicines. Some drugs should not be used with amoxicillin, clarithromycin, and omeprazole.

What other drugs will affect Amoxicillin, clarithromycin, and omeprazole

A gout medication called colchicine (Colcrys) can interact with clarithromycin and cause serious or life-threatening medical problems. You should not take colchicine during your treatment with amoxicillin, clarithromycin, and omeprazole, especially if you are an older adult with kidney disease.

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Clarithromycin can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Tell your doctor about all your current medicines, especially:

cilostazol;

carbamazepine;

probenecid;

sildenafil (Viagra and others);

tacrolimus;

theophylline;

heart rhythm medication;

HIV/AIDS medication;

a sedative such as alprazolam, midazolam, triazolam, Xanax, or Versed;

"statin" cholesterol medication; or

a blood thinner (warfarin, Coumadin, Jantoven).

This list is not complete and many other drugs may affect amoxicillin, clarithromycin, and omeprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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