Anastrozole

Generic name: Anastrozole
Brand names: Arimidex
Dosage form: oral tablet (1 mg)

Usage of Anastrozole

Anastrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.

Anastrozole is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox).

Anastrozole may also be used for purposes not listed in this medication guide.

Anastrozole side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Anastrozole may decrease blood flow to your heart, especially if you have ever had coronary artery disease (clogged arteries). Seek medical attention if you have new or worsening chest pain, or if you feel short of breath.

Anastrozole may cause serious side effects. Call your doctor at once if you have:

shortness of breath (even with mild exertion), swelling, rapid weight gain;

numbness, prickly feeling, pain, or weakness in your hands or wrists;

symptoms of bone fracture--bruising, swelling, tenderness, pain that worsens with movement;

liver problems--right-sided upper stomach pain, yellowing of your skin or eyes, and not feeling well; or

signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Common side effects of anastrozole may include:

numbness, tingling, or tickling feeling in your skin;

hot flashes;

weakness;

joint pain or stiffness;

bone pain, risk of fracture;

swelling in your arms, legs, or feet;

sore throat, cough, shortness of breath;

headache, back pain;

depression, sleep problems (insomnia);

high blood pressure;

nausea, vomiting; or

rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Anastrozole

You should not use anastrozole if you are allergic to it, or if you have not yet completed menopause.

Anastrozole is not approved for use in men or children.

You should not take anastrozole if you also take tamoxifen.

Tell your doctor if you have ever had:

heart problems;

coronary artery disease (clogged artery disease);

high cholesterol; or

osteoporosis or low bone mineral density.

Hormonal cancer treatment can weaken your bones. You may be more likely to have a broken bone while using anastrozole. Talk with your doctor about ways to keep your bones healthy.

Although it is not likely that a postmenopausal woman would be pregnant, anastrozole may harm an unborn baby. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control if you are not past menopause. Keep using birth control for at least 3 weeks after your last dose of anastrozole. Tell your doctor if you become pregnant.

Do not breastfeed while using anastrozole, and for at least 2 weeks after your last dose.

How to use Anastrozole

Usual Adult Dose for Breast Cancer:

Initial dose: 1 mg orally taken once a dayDuration of therapy: Until tumor progression (treatment of advanced breast cancer); unknown (adjuvant treatment of early breast cancer)Uses: -Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer;-First-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer;-Second-line treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.

Warnings

What other drugs will affect Anastrozole

Anastrozole may not work as well if you take it together with an estrogen medication (such as hormone replacement therapy, estrogen creams, or birth control pills, injections, implants, skin patches, and vaginal rings or vaginal suppositories).

Other drugs may affect anastrozole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Popular FAQ

Veridex, a brand name drug from Turkey, has been reported as containing the breast cancer medicine anastrozole. Anastrozole is known as Arimidex in the U.S. Continue reading

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