Aranesp
Generic name: Darbepoetin Alfa
Drug class:
Recombinant human erythropoietins
Usage of Aranesp
Aranesp is a man-made form of a protein that helps your body produce red blood cells. This protein may be reduced when you have kidney failure or use certain medications. When fewer red blood cells are produced, you can develop a condition called anemia.
Aranesp is used to treat anemia caused by chemotherapy or chronic kidney disease.
Aranesp side effects
Get emergency medical help if you have signs of an allergic reaction to Aranesp (hives, wheezing, difficult breathing, severe dizziness or fainting, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Darbepoetin alfa can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use Aranesp. Seek emergency medical help if you have:
Call your doctor at once if you have:
Common Aranesp side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Aranesp
You should not use Aranesp if you are allergic to darbepoetin alfa, or if you have:
Aranesp may shorten remission time in some people with head and neck cancer who are also being treated with radiation. Darbepoetin alfa may also shorten survival time in certain people with breast cancer, non-small cell lung cancer, head and neck cancer, cervical cancer, or lymphoid cancer. Talk with your doctor about the risks and benefits of using this medicine.
Tell your doctor if you have ever had:
Tell your doctor if you are pregnant or breastfeeding.
Relate drugs
- Aranesp
- Darbepoetin alfa
- Epoetin alfa
- Epoetin alfa-epbx
- Epoetin beta and methoxy polyethylene glycol
- Epogen
- Methoxy polyethylene glycol-epoetin beta
- Mircera
- Omontys
- Peginesatide
- Procrit
- Retacrit
How to use Aranesp
Usual Adult Dose of Aranesp for Anemia Associated with Chronic Renal Failure:
Chronic Kidney Disease (CKD) Patients Not on Dialysis: Initial dose: 0.45 mcg/kg IV or subcutaneously once every 4 weeks as appropriate Comments: -Initiate treatment only when hemoglobin is less than 10 g/dL, rate of hemoglobin decline indicates likelihood of requiring RBC transfusion, and reducing risk of alloimmunization and/or other RBC transfusion-related risks is a goal. CKD Patients on Dialysis: Initial dose: 0.45 mcg/kg IV or subcutaneously once a week or 0.75 mcg/kg once every 2 weeks as appropriate Comments: -Initiate treatment when hemoglobin is less than 10 g/dL. -IV route is recommended for patients on hemodialysis.
Usual Adult Dose of Aranesp for Anemia Associated with Chemotherapy:
Initial dose: 2.25 mcg/kg subcutaneously once a week or 500 mcg subcutaneously once every 3 weeks Duration of therapy: Until completion of chemotherapy course Comments: -Initiate treatment if hemoglobin is less than 10 g/dL and a minimum of 2 additional months of chemotherapy is planned. -Use the lowest dose necessary to avoid RBC transfusions. Use: Treatment of anemia in patients with non-myeloid malignancies where anemia is due to the effect of concomitant myelosuppressive chemotherapy.
Usual Pediatric Dose of Aranesp for Anemia Associated with Chronic Renal Failure:
Less than 18 Years: Initial dose: -Chronic Kidney Disease (CKD) Patients Not on Dialysis: 0.45 mcg/kg IV or subcutaneously once a week or 0.75 mcg/kg once every 2 weeks -CKD Patients on Dialysis: 0.45 mcg/kg IV or subcutaneously once a week Comments: Initiate treatment when hemoglobin is less than 10 g/dL.
Warnings
Aranesp can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. Seek emergency medical help if you have: chest pain, shortness of breath, sudden numbness or weakness, confusion, problems with vision or balance, trouble speaking or understanding, or pain or coldness in an arm or leg.
Aranesp may also shorten remission time or survival time in some people with certain types of cancer. Talk with your doctor about the risks and benefits of using darbepoetin alfa.
Before using Aranesp, tell your doctor if you have heart disease, congestive heart failure, high blood pressure, kidney disease, a blood cell or clotting disorder, cancer, a seizure disorder, a latex allergy, or a history of stroke, heart attack, or blood clots.
You should not use this medicine if you have uncontrolled high blood pressure, or if you have ever had pure red cell aplasia (PRCA, a type of anemia) caused by using darbepoetin alfa or epoetin alfa (Epogen or Procrit).
To be sure Aranesp is helping your condition, your blood may need to be tested often. Your blood pressure will also need to be checked. Visit your doctor regularly.
Contact your doctor if you feel light-headed or unusually weak or tired. These may be signs that your body has stopped responding to Aranesp.
What other drugs will affect Aranesp
Other drugs may interact with Aranesp, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Popular FAQ
Jesduvroq and Aranesp are both used to raise hemoglobin levels and to treat anemia associated with chronic kidney disease (CKD). However, they differ in their active ingredients, indications, ways of working in the body, routes, frequency of administration, side effect profiles, and warnings. Neither Jesduvroq nor Aranesp has been proven to improve quality of life, tiredness (fatigue), or well-being. Continue reading
Jesduvroq and Aranesp are both used to raise hemoglobin levels and to treat anemia associated with chronic kidney disease (CKD). However, they differ in their active ingredients, indications, ways of working in the body, routes, frequency of administration, side effect profiles, and warnings. Neither Jesduvroq nor Aranesp has been proven to improve quality of life, tiredness (fatigue), or well-being. Continue reading
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