Arsenic trioxide
Generic name: Arsenic Trioxide
Brand names: Trisenox
Dosage form: intravenous solution (1 mg/mL; 2 mg/mL)
Drug class:
Miscellaneous antineoplastics
Usage of Arsenic trioxide
Arsenic trioxide is used to treat a cancer of the blood and bone marrow called acute promyelocytic (pro-MYE-loe-SIT-ik) leukemia, or APL.
Arsenic trioxide is sometimes given in combination with another medicine called tretinoin.
Arsenic trioxide may also be used for other purposes not listed in this medication guide.
Arsenic trioxide side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Arsenic trioxide can cause a condition called differentiation syndrome, which affects blood cells and can be fatal if not treated. This condition may occur within 1 days to 2 months after you start taking arsenic trioxide.
Seek medical help right away if you have symptoms of differentiation syndrome:
Also call your doctor right away if you have:
Common side effects of arsenic trioxide may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Arsenic trioxide
You should not be treated with arsenic trioxide if you are allergic to it.
Tell your doctor if you have ever had:
Arsenic trioxide can harm an unborn baby if the mother or the father is using arsenic trioxide.
It may be harder for you to get a woman pregnant while you are using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
Relate drugs
- Abiraterone
- Abiraterone, micronized
- Adagrasib
- Adstiladrin
- Altretamine
- Amivantamab
- Amivantamab-vmjw
- Arsenic trioxide
- Asparaginase Erwinia chrysanthemi
- Asparaginase erwinia chrysanthemi recombinant-rywn
- Asparlas
- Axicabtagene ciloleucel
- Azacitidine
- Azacitidine (Injection)
- Azacitidine (Oral)
- Abecma
- Bacillus of calmette and guerin vaccine, live (Intradermal)
- Bacillus of calmette and guerin vaccine, live (Intravesical)
- BCG intravesical
- Belantamab mafodotin
- Belantamab mafodotin-blmf
- Belzutifan
- Besponsa
- Bexarotene
- Bexarotene (Oral)
- Blenrep
- Brexucabtagene autoleucel
- Breyanzi
- Calaspargase pegol
- Calaspargase pegol-mknl
- Camptosar
- Carvykti
- Ciltacabtagene autoleucel
- Danyelza
- Dinutuximab
- Elahere
- Elotuzumab
- Elzonris
- Empliciti
- Enasidenib
- Enfortumab vedotin
- Enfortumab vedotin-ejfv
- Erwinaze
- Hexalen
- Hycamtin (Topotecan Intravenous)
- Hycamtin (Topotecan Oral)
- Hycamtin oral/injection
- Idecabtagene vicleucel
- Idhifa
- Imlygic
- Inotuzumab ozogamicin
- Irinotecan
- Irinotecan liposomal
- Irinotecan liposome
- Ivosidenib
- Kimmtrak
- Krazati
- Kymriah
- Lartruvo
- Levamisole
- Lisocabtagene maraleucel
- Loncastuximab tesirine
- Loncastuximab tesirine-lpyl
- Lumakras
- Lumoxiti
- Lunsumio
- Lysodren
- Matulane
- Mirvetuximab soravtansine
- Mirvetuximab soravtansine-gynx
- Mitotane
- Mogamulizumab
- Mogamulizumab-kpkc
- Mosunetuzumab
- Mosunetuzumab-axgb
- Moxetumomab pasudotox
- Moxetumomab pasudotox-tdfk
- Nadofaragene firadenovec-vncg
- Naxitamab
- Naxitamab-gqgk
- Novaplus Irinotecan Hydrochloride
- Olaratumab
- Olutasidenib
- Omacetaxine
- Oncaspar
- Onivyde
- Onureg
- Padcev
- Pegaspargase
- Polatuzumab vedotin
- Polatuzumab vedotin-piiq
- Polivy
- Poteligeo
- Procarbazine
- Rezlidhia
- Rozanolixizumab-noli
- Rybrevant
- Rylaze
- Rystiggo
- Sacituzumab govitecan
- Sacituzumab govitecan-hziy
- Selinexor
- Sotorasib
- Synribo
- Tagraxofusp
- Tagraxofusp-erzs
- Talimogene laherparepvec
- Talquetamab
- Talquetamab-tgvs
- Talvey
- Targretin
- Targretin (Bexarotene Oral)
- Tazemetostat
- Tazverik
- Tebentafusp
- Tebentafusp-tebn
- Tecartus
- Teclistamab
- Teclistamab-cqyv
- Tecvayli
- Theracys
- Tibsovo
- Tice BCG
- Tice BCG Live (for intravesical use)
- Tisagenlecleucel
- Tisotumab vedotin
- Tisotumab vedotin-tftv
- Tivdak
- Topotecan (Intravenous)
- Topotecan (Oral)
- Topotecan oral/injection
- Tretinoin
- Tretinoin (Oral)
- Trisenox
- Trodelvy
- Unituxin
- Venclexta
- Venetoclax
- Verteporfin
- Vesanoid
- Vidaza
- Visudyne
- Welireg
- Xpovio
- Xpovio 40 mg once-weekly
- Xpovio 40 mg twice-weekly
- Xpovio 60 mg twice-weekly
- Xpovio 80 mg twice-weekly
- Yescarta
- Yonsa
- Yonsa (Abiraterone Oral)
- Yonsa (Abiraterone, micronized Oral)
- Zynlonta
- Zytiga
How to use Arsenic trioxide
Usual Adult Dose for Acute Promyelocytic Leukemia:
INDUCTION CYCLE: 0.15 mg/kg IV over 1 to 2 hours once a day until bone marrow remission or up to a maximum of 60 daysCONSOLIDATION CYCLE: 0.15 mg/kg IV over 1 to 2 hours once a day for 25 doses over a period of up to 5 weeks; begin consolidation 3 to 6 weeks after completion of induction therapyUse: Induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy, and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression
Usual Pediatric Dose for Acute Promyelocytic Leukemia:
4 YEARS AND OLDER:INDUCTION CYCLE: 0.15 mg/kg IV over 1 to 2 hours once a day until bone marrow remission or up to a maximum of 60 daysCONSOLIDATION CYCLE: 0.15 mg/kg IV over 1 to 2 hours once a day for 25 doses over a period of up to 5 weeks; begin consolidation 3 to 6 weeks after completion of induction therapyUse: Induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy, and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression
Warnings
Arsenic trioxide can cause a condition called differentiation syndrome, which affects blood cells and can be fatal if not treated. This condition may occur within 1 days to 2 months after you start taking this medicine.
Seek medical help right away if you have symptoms of differentiation syndrome: fever, dizziness, cough, trouble breathing, swelling, rapid weight gain, or decreased urination.
Arsenic trioxide can cause a serious heart problem. Your risk may be higher if you also use certain other medicines. Tell your doctor about all your current medicines and any you start or stop using.
Get emergency medical help if you have fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness.
What other drugs will affect Arsenic trioxide
Arsenic trioxide can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Other drugs may affect arsenic trioxide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
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The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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