Atovaquone and proguanil
Generic name: Atovaquone And Proguanil
Dosage form: oral tablet (250 mg-100 mg; 62.5 mg-25 mg)
Drug class:
Antimalarial combinations
Usage of Atovaquone and proguanil
Atovaquone and proguanil is a combination medicine used to treat or prevent malaria, a disease caused by parasites. These medicines work by interfering with the growth of parasites in the red blood cells of the human body.
Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.
Atovaquone and proguanil may also be used for purposes not listed in this medication guide.
Atovaquone and proguanil side effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Atovaquone and proguanil may cause serious side effects. Call your doctor at once if you have:
Common side effects of atovaquone and proguanil may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Atovaquone and proguanil
You should not use this medicine if you are allergic to atovaquone or proguanil.
Do not use atovaquone and proguanil to prevent malaria if you have severe kidney disease.
Atovaquone and proguanil should not be used to treat malaria in a child who weighs less than 11 pounds (5 kilograms), and should not be used to prevent malaria in a child who weighs less than 24 pounds (11 kilograms).
Tell your doctor if you have ever had:
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Malaria is more likely to cause death in a pregnant woman. If you are pregnant, talk with your doctor about the risks of traveling to areas where malaria is common.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
Relate drugs
- Artemether and lumefantrine
- Atovaquone and proguanil
- Coartem
- Fansidar
- Malarone
- Malarone Pediatric
- Pyrimethamine and sulfadoxine
How to use Atovaquone and proguanil
Usual Adult Dose for Malaria:
1 g atovaquone/400 mg proguanil (four adult strength tablets as a single dose) orally once a day for 3 consecutive days
Usual Adult Dose for Malaria Prophylaxis:
Prophylactic therapy should start 1 or 2 days before entering a malaria-endemic area and continued daily during the stay and for 7 days after return.250 mg atovaquone/100 mg proguanil (one adult strength tablet) orally once a day
Usual Pediatric Dose for Malaria:
Less than 5 kg ABW (actual body weight): Safety and efficacy has not been established.5 to 8 kg ABW: 125 mg atovaquone/50 mg proguanil (2 pediatric tablets) once daily for 3 consecutive days.9 to 10 kg ABW: 187.5 mg atovaquone/75 mg proguanil (3 pediatric tablets) once daily for 3 consecutive days.11 to 20 kg ABW: 250 mg atovaquone/100 mg proguanil (one adult strength or four pediatric tablets as a single dose) orally once a day for 3 consecutive days21 to 30 kg ABW: 500 mg atovaquone/200 mg proguanil (two adult strength tablets as a single dose) orally once a day for 3 consecutive days31 to 40 kg ABW: 750 mg atovaquone/300 mg proguanil (three adult strength tablets as a single dose) orally once a day for 3 consecutive daysGreater than 40 kg ABW: 1 g atovaquone/400 mg proguanil (four adult strength tablets as a single dose) orally once a day for 3 consecutive days
Usual Pediatric Dose for Malaria Prophylaxis:
Prophylactic treatment should start 1 or 2 days before entering a malaria-endemic area and continued daily during the stay and for 7 days after return.11 to 20 kg ABW (actual body weight): 62.5 mg atovaquone/25 mg proguanil (one pediatric tablet) orally once a day21 to 30 kg ABW: 125 mg atovaquone/50 mg proguanil (two pediatric tablets as a single dose) orally once a day31 to 40 kg ABW: 187.5 mg atovaquone/75 mg proguanil (three pediatric tablets as a single dose) orally once a dayGreater than 40 kg ABW: 250 mg atovaquone/100 mg proguanil (one adult strength tablet) orally once a day
Warnings
You should not use atovaquone and proguanil to prevent malaria if you have severe kidney disease.
What other drugs will affect Atovaquone and proguanil
Tell your doctor about all other medicines you use, especially:
This list is not complete. Other drugs may affect atovaquone and proguanil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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