Atropine, hyoscyamine, methenamine, methylene blue, phenyl salicylate, and benzoic acid

Generic name: Atropine, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate, And Benzoic Acid
Drug class: Urinary antispasmodics

Usage of Atropine, hyoscyamine, methenamine, methylene blue, phenyl salicylate, and benzoic acid

Atropine , hyoscyamine , methenamine , methylene blue, phenyl salicylate , and benzoic acid combination medicine is an anticholinergic, anti-infective, and analgesic. It is given by mouth to help relieve the discomfort caused by urinary tract infections; however, it will not cure the infection itself. This combination medicine may also be used for other conditions as determined by your doctor.

This medicine is available only with your doctor's prescription.

Atropine, hyoscyamine, methenamine, methylene blue, phenyl salicylate, and benzoic acid side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare

Blurred vision

eye pain

skin rash or hives

Symptoms of overdose

Blood in urine and/or stools

diarrhea

dizziness

drowsiness (severe)

fast heartbeat

flushing or redness of face

headache (severe or continuing)

lower back pain

pain or burning while urinating

ringing or buzzing in the ears

shortness of breath or troubled breathing

sweating

unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Difficult urination (more common with large doses taken over a prolonged period of time)

dryness of mouth, nose, or throat

nausea or vomiting

stomach upset or pain (more common with large doses taken over a prolonged period of time)

This medicine may cause your urine and/or stools to turn blue or blue-green. This is to be expected while you are taking this medicine.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Atropine, hyoscyamine, methenamine, methylene blue, phenyl salicylate, and benzoic acid

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Unusual excitement, nervousness, restlessness or irritability, and unusual warmth, dryness, and flushing of skin are more likely to occur in children, who are usually more sensitive to the effects of atropine and hyoscyamine (contained in this combination medicine). Also, when atropine and hyoscyamine are given to children during hot weather, a rapid increase in body temperature may occur. In infants and children, especially those with spastic paralysis or brain damage, this medicine may be more likely to cause severe side effects.

Geriatric

Confusion or memory loss, constipation, difficult urination, excitement, agitation, drowsiness, or dryness of mouth may be more likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of atropine and hyoscyamine. Also, this combination medicine may cause eye pain in patients who have untreated glaucoma.

Breast Feeding

Benzoic Acid

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Methylene BlueMethenamineAtropineHyoscyamine

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Acetazolamide

Ambenonium

Amitriptyline

Amoxapine

Amphetamine

Atomoxetine

Benzphetamine

Bupropion

Carbamazepine

Carbidopa

Carbinoxamine

Clomipramine

Codeine

Cyclobenzaprine

Desipramine

Desvenlafaxine

Deutetrabenazine

Dexmethylphenidate

Dextroamphetamine

Doxepin

Doxylamine

Duloxetine

Entacapone

Fenfluramine

Fluoxetine

Fluvoxamine

Hydroxytryptophan

Imipramine

Isocarboxazid

Levodopa

Levomilnacipran

Linezolid

Lisdexamfetamine

Mafenide

Maprotiline

Meperidine

Methamphetamine

Methylphenidate

Milnacipran

Mirtazapine

Nortriptyline

Ozanimod

Paroxetine

Phenelzine

Phentermine

Potassium Citrate

Protriptyline

Pseudoephedrine

Rizatriptan

Safinamide

Selegiline

Serdexmethylphenidate

Sertraline

Silver Sulfadiazine

Solriamfetol

Sulfabenzamide

Sulfacetamide

Sulfacytine

Sulfadiazine

Sulfamerazine

Sulfamethazine

Sulfamethoxazole

Sulfanilamide

Sulfapyridine

Sulfasalazine

Sulfathiazole

Sulfisoxazole

Sumatriptan

Tapentadol

Tramadol

Tranylcypromine

Trazodone

Trimipramine

Tryptophan

Venlafaxine

Vilazodone

Viloxazine

Vortioxetine

Zolmitriptan

Zonisamide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aceclofenac

Acemetacin

Albuterol

Alfentanil

Almotriptan

Alprazolam

Amantadine

Amifampridine

Amineptine

Amitriptylinoxide

Amtolmetin Guacil

Atropine

Balsalazide

Benzhydrocodone

Bismuth Subsalicylate

Bromazepam

Bromfenac

Brompheniramine

Bufexamac

Buprenorphine

Bupropion

Buspirone

Butalbital

Butorphanol

Calcium Oxybate

Cannabidiol

Cannabis

Celecoxib

Cetirizine

Chlorpheniramine

Choline Magnesium Trisalicylate

Choline Salicylate

Clobazam

Clonazepam

Clonixin

Clozapine

Cocaine

Codeine

Daridorexant

Dexibuprofen

Dexketoprofen

Dexmedetomidine

Dextromethorphan

Dibenzepin

Diclofenac

Difenoxin

Diflunisal

Dihydrocodeine

Diphenoxylate

Dipyrone

Dolasetron

Donepezil

Droxicam

Eletriptan

Epinephrine

Esketamine

Etodolac

Etofenamate

Etoricoxib

Felbinac

Fenoprofen

Fentanyl

Fepradinol

Feprazone

Flibanserin

Floctafenine

Flufenamic Acid

Flurbiprofen

Formoterol

Frovatriptan

Furazolidone

Gabapentin

Gabapentin Enacarbil

Glucagon

Glycopyrrolate

Glycopyrronium Tosylate

Granisetron

Hydrocodone

Hydromorphone

Indomethacin

Iobenguane I 123

Iobenguane I 131

Iproniazid

Ketamine

Ketoprofen

Lacosamide

Lasmiditan

Lemborexant

Levocetirizine

Levorphanol

Lithium

Lofepramine

Lofexidine

Lorcaserin

Lornoxicam

Loxapine

Loxoprofen

Lumiracoxib

Macimorelin

Magnesium Oxybate

Magnesium Salicylate

Meclofenamate

Mefenamic Acid

Melitracen

Meloxicam

Mesalamine

Metaxalone

Methacholine

Methadone

Metoclopramide

Midodrine

Moclobemide

Morniflumate

Morphine

Morphine Sulfate Liposome

Nabumetone

Nalbuphine

Naproxen

Naratriptan

Nefazodone

Nepafenac

Nialamide

Niflumic Acid

Nimesulide

Nimesulide Beta Cyclodextrin

Norepinephrine

Olanzapine

Olsalazine

Ondansetron

Opipramol

Oxaprozin

Oxycodone

Oxymetazoline

Oxymorphone

Oxyphenbutazone

Palonosetron

Parecoxib

Pentazocine

Periciazine

Phenobarbital

Phenylbutazone

Piketoprofen

Piroxicam

Potassium Oxybate

Pregabalin

Primidone

Procarbazine

Proglumetacin

Propyphenazone

Proquazone

Quetiapine

Rasagiline

Remifentanil

Remimazolam

Revefenacin

Rofecoxib

Ropeginterferon Alfa-2b-njft

Salicylamide

Salicylic Acid

Salsalate

Scopolamine

Secretin Human

Sibutramine

Sodium Oxybate

Sodium Salicylate

St John's Wort

Sufentanil

Sulfasalazine

Sulindac

Tapentadol

Tenoxicam

Tianeptine

Tiaprofenic Acid

Tiotropium

Tolfenamic Acid

Tolmetin

Topiramate

Trolamine Salicylate

Valbenazine

Valdecoxib

Vilanterol

Ziprasidone

Zolpidem

Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acarbose

Arbutamine

Chlorpropamide

Glimepiride

Glipizide

Glyburide

Insulin

Insulin Aspart, Recombinant

Insulin Bovine

Insulin Degludec

Insulin Detemir

Insulin Glargine, Recombinant

Insulin Glulisine

Insulin Lispro, Recombinant

Metformin

Nateglinide

Repaglinide

Tolazamide

Tolbutamide

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Relate drugs

How to use Atropine, hyoscyamine, methenamine, methylene blue, phenyl salicylate, and benzoic acid

While you are taking this combination medicine, it is important for your urine to be acidic. To do this, your doctor may recommend that you eat more protein and such foods as cranberries (especially cranberry juice with vitamin C added), plums, or prunes. You should avoid foods that make the urine more alkaline, such as most fruits (especially citrus fruits and juices), milk, and other dairy products.

Take this medicine only as directed. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Each dose should be taken with a full glass (8 ounces) of water or other liquid (except citrus juices and milk). Drink plenty of water or other liquids every day, unless otherwise directed by your doctor. Drinking enough liquids will help your kidneys work better and lessen your discomfort.

To help clear up your infection completely, keep taking this medicine for the full time of treatment even if you begin to feel better after a few days. Do not miss any doses.

In order for this medicine to work well, your urine must be acid (pH 5.5 or below). To make sure that your urine is acid:

Before you start taking this medicine, check your urine with phenaphthazine paper or another test to see if it is acid. If you have any questions about this, check with your health care professional.

You may need to change your diet; however, check with your doctor first if you are on a special diet (for example, for diabetes). To help make your urine more acid you should avoid most fruits (especially citrus fruits and juices), milk and other dairy products, and other foods which make the urine more alkaline. Eating more protein and foods such as cranberries (especially cranberry juice with vitamin C added), plums, or prunes may also help. If your urine is still not acid enough, check with your doctor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):

For relief of urinary tract symptoms:

Adults and children 12 years of age and older—1 to 2 tablets four times a day.

Children 6 to 12 years of age—Dose must be determined by the doctor.

Children up to 6 years of age—Use is not recommended.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Warnings

If your symptoms do not improve within a few days or if they become worse, check with your doctor.

These medicines may make you sweat less, causing your body temperature to increase. Use extra care not to become overheated during exercise or hot weather while you are taking this medicine, since overheating may result in heat stroke. Also, hot baths or saunas may make you dizzy or faint while you are taking this medicine.

This medicine may cause some people to have blurred vision. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not able to see well. If your vision continues to be blurred, check with your doctor.

This medicine may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Do not take this medicine within 2 or 3 hours of taking antacids or medicine for diarrhea. Taking antacids or antidiarrhea medicines and this medicine too close together may prevent this medicine from working properly.

Disclaimer

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