Aubagio
Generic name: Teriflunomide
Drug class:
Selective immunosuppressants
Usage of Aubagio
Aubagio affects the immune system and reduces swelling and inflammation in the nervous system.
Aubagio is used to treat relapsing forms of multiple sclerosis in adults (including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease).
Aubagio is not a cure for MS.
Aubagio side effects
Get emergency medical help if you have signs of an allergic reaction to Aubagio (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Stop using this medicine and call your doctor at once if you have:
Common Aubagio side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Aubagio
You should not use Aubagio if you are allergic to teriflunomide or leflunomide, or if:
Do not use Aubagio if you are pregnant or may become pregnant You will need to have a negative pregnancy test before starting this treatment. Avoid getting pregnant until after you stop taking this medicine and undergo a "drug elimination" procedure to help rid your body of this medicine. Stop taking Aubagio and call your doctor right away if you miss a period or think you might be pregnant.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
Use birth control to prevent pregnancy while you are taking this medicine. After you stop taking Aubagio, continue using birth control until you have received blood tests to make sure the drug has been eliminated from your body.
If you become pregnant while taking Aubagio or within 2 years after you stop, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of teriflunomide on the baby.
If you are a man, use effective birth control to prevent pregnancy if your sex partner is able to get pregnant. After your treatment ends, keep using birth control until you have received the medications to help your body eliminate teriflunomide.
You should not breastfeed while using this medicine.
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How to use Aubagio
Usual Adult Dose for Multiple Sclerosis:
7 mg or 14 mg orally once a day Use: Treatment of patients with relapsing forms of multiple sclerosis.
Warnings
Do not use Aubagio if you are pregnant or may become pregnant. You will need to have a negative pregnancy test before starting this treatment. Tell your doctor right away if you become pregnant during treatment or within 2 years after your treatment ends.
Teriflunomide can cause severe liver problems. You should not use this medicine if you have severe liver disease or if you are also taking leflunomide (Arava). Tell your doctor if you have a history of liver disease.
Call your doctor at once if you have signs of liver problems: upper stomach pain, loss of appetite, dark urine, or jaundice (yellowing of the skin or eyes).
Your doctor may need to test your liver function up to 6 months before you start taking Aubagio, and then every month when you first start taking this medicine.
Teriflunomide can lower blood cells that help your body fight infections. This can make it easier for you to get sick from being around others who are ill. While using Aubagio, you may need blood tests every 6 months. Your blood pressure will also need to be checked often.
After you stop taking Aubagio, the drug could stay in your body for up to 2 years. You may need to be treated with other medications to help your body eliminate teriflunomide quickly. Follow your doctor's instructions.
What other drugs will affect Aubagio
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Your doctor may need to adjust the doses of any other medicines you take on a regular basis.
Many drugs can interact with teriflunomide. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Popular FAQ
Weight loss is reported as a common side effect of Aubagio, occurring in 1% to 10% of people in post-marketing studies, although it is not listed as a side effect in the product information. Rapid weight gain has also been reported with Aubagio but this is considered uncommon. Continue reading
Aubagio is made by Sanofi Genzyme which is the specialty care business arm of Sanofi. It is unclear where Aubagio is manufactured, as Sanofi has 69 manufacturing sites in 32 countries, but the new digital manufacturing site in Framingham, Ma, USA has been reported to make medicines for Sanofi Genzyme’s specialty care portfolio. Aubagio is a specialty medicine that may be used for the treatment of Multiple Sclerosis. Continue reading
Aubagio is unlikely to reduce fatigue associated with Multiple Sclerosis (MS). 85% of patients with MS report fatigue and 76.6% report that fatigue has a significant impact on their lives. One study found ponesimod to be superior to Aubagio at reducing fatigue as measured by The Fatigue Symptoms and Impacts Questionnaire–Relapsing Multiple Sclerosis which is a patient-reported questionnaire designed to assess fatigue-related symptoms and how they affect people with MS. The investigators found that the fatigue of ponesimod patients stabilized, while that of the Aubagio patients worsened over time. Continue reading
It does not matter if you take Aubagio in the morning or at night. But you must take it at around the same time each day. So if you decide to take your Aubagio in the morning, then take it every morning. If you decide to take it at night then take it every night. If you experience fatigue, tiredness, or weakness with Aubagio, you may find it better to take it at night. Continue reading
Weight loss is reported as a common side effect of Aubagio, occurring in 1% to 10% of people in post-marketing studies, although it is not listed as a side effect in the product information. Rapid weight gain has also been reported with Aubagio but this is considered uncommon. Continue reading
Aubagio is made by Sanofi Genzyme which is the specialty care business arm of Sanofi. It is unclear where Aubagio is manufactured, as Sanofi has 69 manufacturing sites in 32 countries, but the new digital manufacturing site in Framingham, Ma, USA has been reported to make medicines for Sanofi Genzyme’s specialty care portfolio. Aubagio is a specialty medicine that may be used for the treatment of Multiple Sclerosis. Continue reading
Aubagio is unlikely to reduce fatigue associated with Multiple Sclerosis (MS). 85% of patients with MS report fatigue and 76.6% report that fatigue has a significant impact on their lives. One study found ponesimod to be superior to Aubagio at reducing fatigue as measured by The Fatigue Symptoms and Impacts Questionnaire–Relapsing Multiple Sclerosis which is a patient-reported questionnaire designed to assess fatigue-related symptoms and how they affect people with MS. The investigators found that the fatigue of ponesimod patients stabilized, while that of the Aubagio patients worsened over time. Continue reading
It does not matter if you take Aubagio in the morning or at night. But you must take it at around the same time each day. So if you decide to take your Aubagio in the morning, then take it every morning. If you decide to take it at night then take it every night. If you experience fatigue, tiredness, or weakness with Aubagio, you may find it better to take it at night. Continue reading
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