Avacopan

Generic name: Avacopan
Brand names: Tavneos
Dosage form: oral capsule (10 mg)
Drug class: Selective immunosuppressants

Usage of Avacopan

Avacopan is used with other medicines (including glucocorticoids) to treat adults with granulomatosis with polyangiitis (previously known as Wegener's granulomatosis). avacopan is also used to treat adults with microscopic polyangiitis.

Avacopan may also be used for purposes not listed in this medication guide.

Avacopan side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Avacopan may cause serious side effects. Call your doctor at once if you have:

signs of liver problems--loss of appetite, pain or swelling in your stomach, swelling in your legs, easy bleeding, drowsiness, confusion, or jaundice (yellowing of the skin or eyes); or

signs of serious infections--fever, cold symptoms (runny nose or sore throat), flu symptoms (cough, tiredness, and body aches), earache or headache, painful urination, cold sores in mouth or throat.

Common side effects of avacopan may include:

tiredness;

rash;

headache, dizziness;

burning or prickling sensation;

increase in blood creatinine;

nausea, diarrhea, vomiting, stomach pain; or

severe headache, blurred vision, pounding in your neck or ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Avacopan

You should not use avacopan if you are allergic to it or any of its inactive ingredients.

Tell your doctor if you have ever had:

liver problems or abnormal liver function tests;

hepatitis B or C; or

if you currently have an infection.

Tell your doctor if you are pregnant or plan to become pregnant, or breastfeeding or plan to breastfeed. Talk to your doctor about the best way to feed your baby if you take avacopan.

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How to use Avacopan

Usual Adult Dose for Vasculitis:

Recommended dose: 30 mg orally twice a day with food Comments:-Obtain liver function tests and screen for hepatitis B prior to treatment initiation. -Consider monitoring WBC count before starting therapy. -This drug is used in combination with standard therapy, including glucocorticoids. Use: As an adjunctive treatment of adult patients with severe active anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (granulomatosis with polyangiitis and microscopic polyangiitis) in combination with standard therapy including glucocorticoids; this drug does not eliminate glucocorticoid use.

Warnings

Call your doctor at once if you have loss of appetite, pain or swelling in your stomach, swelling in your legs, easy bleeding, drowsiness, confusion, or jaundice (yellowing of the skin or eyes).

What other drugs will affect Avacopan

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Other drugs may affect avacopan, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Disclaimer

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